Catalog No.
PHG19701
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SIGLEC14 (Gln24-Leu137).
Applications
ELISA, IHC, WB
Recommended Dilution
| Application |
Dilution |
| ELISA |
1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000 |
Target
Sialic acid-binding Ig-like lectin 14,Siglec-14,SIGLEC14
Purification
Purified by antigen affinity column.
Accession
Q08ET2
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note
For research use only.
Siglec-15: an immune system Siglec conserved throughout vertebrate evolution., PMID:17483134
Deletion polymorphism of SIGLEC14 and its functional implications., PMID:19369701
Colloquium paper: uniquely human evolution of sialic acid genetics and biology., PMID:20445087
Detection of anti-Siglec-14 alloantibodies in blood components implicated in nonhaemolytic transfusion reactions., PMID:21477167
Inhaled corticosteroids increase siglec-5/14 expression in sputum cells of COPD patients., PMID:25252903
Sialylation pattern in lung epithelial cell line and Siglecs expression in monocytic THP-1 cells as cellular indicators of cigarette smoke - induced pathology in vitro., PMID:29781747
Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses., PMID:30377253
Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers., PMID:31882261
O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells., PMID:34878295
Validation of disease-specific biomarkers for the early detection of bronchopulmonary dysplasia., PMID:35595912
Genome-Wide Determinants of Cellular Immune Responses to Mumps Vaccine., PMID:37205333
Genome-wide determinants of cellular immune responses to mumps vaccine., PMID:37778899
Therapeutic potential to target sialylation and SIGLECs in neurodegenerative and psychiatric diseases., PMID:38529039
For research use only. Not for human or drug use.
