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Anti-P2X purinoceptor 7 Antibody (N256/27)

Catalog #:   RHJ44802 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG2a, kappa
Applications: IHC, WB
Overview

Catalog No.

RHJ44802

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

P2RX7, Purinergic receptor, P2X purinoceptor 7, P2X7, P2Z receptor, ATP receptor

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Applications

IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

N256/27

Data Image
References

The Anti-Human P2X7 Monoclonal Antibody (Clone L4) Can Mediate Complement-Dependent Cytotoxicity of Human Leukocytes., PMID:39853757

Purinergic 2X 4 (P2X4), but not P2X7, receptors increase cytosolic [Ca2+] and stimulate mucin secretion in rat conjunctival goblet cells to maintain ocular surface health., PMID:37580003

NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload., PMID:36440584

Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions., PMID:34996944

The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells., PMID:34548395

Confocal Blood Flow Videomicroscopy of Thrombus Formation over Human Arteries and Local Targeting of P2X7., PMID:33920051

Structural and Functional Features of the P2X4 Receptor: An Immunological Perspective., PMID:33897694

Immunohistochemical evidence of P2X7R, P2X4R and CaMKK2 in pyramidal neurons of frontal cortex does not align with Alzheimer's disease., PMID:33838119

Microglia: The Missing Link to Decipher and Therapeutically Control MS Progression?, PMID:33801644

Update of P2X receptor properties and their pharmacology: IUPHAR Review 30., PMID:33125712

Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells., PMID:32908225

The Purinergic Receptor P2rx3 is Required for Spiral Ganglion Neuron Branch Refinement during Development., PMID:32675174

Production, characterization, and application of a monoclonal antibody specific for the extracellular domain of human P2X7R., PMID:31930453

Carbon Nanomaterials Stimulate HMGB1 Release From Macrophages and Induce Cell Migration and Invasion., PMID:31504961

Activation of P2X7R- NLRP3 pathway in Retinal microglia contribute to Retinal Ganglion Cells death in chronic ocular hypertension (COH)., PMID:31445901

Bacterial lipopolysaccharide and antimicrobial LL-37 enhance ICAM-1 expression and NF-κB p65 phosphorylation in senescent endothelial cells., PMID:31364735

Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain., PMID:31045747

Antibodies and venom peptides: new modalities for ion channels., PMID:30728472

ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival., PMID:30087439

Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody., PMID:30074479

Expression of purinergic P2X7 receptors in subpopulations of peripheral blood mononuclear cells in early-stage of chronic kidney disease., PMID:29375053

Corneal Neovascularization: A Combined Approach of Bevacizumab and Suramin Showed Increased Antiangiogenic Effect Through Downregulation of BFGF and P2X2., PMID:29265937

Role of neurturin in spontaneous itch and increased nonpeptidergic intraepidermal fiber density in a mouse model of psoriasis., PMID:28825602

Abacavir induces platelet-endothelium interactions by interfering with purinergic signalling: A step from inflammation to thrombosis., PMID:28263802

A phase I clinical trial demonstrates that nfP2X7 -targeted antibodies provide a novel, safe and tolerable topical therapy for basal cell carcinoma., PMID:28150889

Characterization of 11C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation., PMID:27765863

The Signaling Mechanism of Contraction Induced by ATP and UTP in Feline Esophageal Smooth Muscle Cells., PMID:26013385

Trophic activity of human P2X7 receptor isoforms A and B in osteosarcoma., PMID:25226385

Expression of purinergic P2X receptor subtypes 1, 2, 3 and 7 in equine laminitis., PMID:24080476

Mechanical vibration inhibits osteoclast formation by reducing DC-STAMP receptor expression in osteoclast precursor cells., PMID:23994170

Effects of ischemia and reperfusion on subpopulations of rat enteric neurons expressing the P2X7 receptor., PMID:23990036

Enhanced purinergic contractile responses and P2X1 receptor expression in detrusor muscle during cycles of hypoxia-glucopenia and reoxygenation., PMID:23975903

Oxidative stress induced by P2X7 receptor stimulation in murine macrophages is mediated by c-Src/Pyk2 and ERK1/2., PMID:23711511

High fatty acids modulate P2X(7) expression and IL-6 release via the p38 MAPK pathway in PC12 cells., PMID:23438872

Characterization of P2X7R and its function in the macrophages of ayu, Plecoglossus altivelis., PMID:23437395

Distribution of purinergic P2X receptors in the equine digit, cervical spinal cord and dorsal root ganglia., PMID:23381684

Involvement of P2X(7) receptors in retinal ganglion cell death after optic nerve crush injury in rats., PMID:23262079

Involvement of the P2X7 purinergic receptor and c-Jun N-terminal and extracellular signal-regulated kinases in cyclooxygenase-2 and prostaglandin E2 induction by LL-37., PMID:23095809

Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation., PMID:22848454

P2X7 signaling promotes microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand., PMID:22789015

Protection from asthma in a high-risk birth cohort by attenuated P2X(7) function., PMID:22743305

ATP induces the death of developing avian retinal neurons in culture via activation of P2X7 and glutamate receptors., PMID:22733428

Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse., PMID:22253851

Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells., PMID:22039237

Adipocyte P2X7 receptors expression: a role in modulating inflammatory response in subjects with metabolic syndrome?, PMID:21978920

P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice., PMID:21670495

Localisation of SCN10A gene product Na(v)1.8 and novel pain-related ion channels in human heart., PMID:21646736

Identification of P2X₃ and P2X₇ purinergic receptors activated by ATP in rat lacrimal gland., PMID:21421865

GDNF levels in the lower lip skin in a rat model of trigeminal neuropathic pain: implications for nonpeptidergic fiber reinnervation and parasympathetic sprouting., PMID:21398037

Vascular CD39/ENTPD1 directly promotes tumor cell growth by scavenging extracellular adenosine triphosphate., PMID:21390184

Datasheet
$ 328
Product specifications
100 μg 328 1 mg 1640

Contact Information

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For research use only. Not for human or drug use.

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Anti-P2X purinoceptor 7 Antibody (N256/27) [RHJ44802]
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