Catalog No.
RHK46001
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
MRS1, Pannexin-1, PANX1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
N122A/17
Divergent sex-specific pannexin-1 mechanisms in microglia and T cells underlie neuropathic pain., PMID:39892387
Unraveling the interplay of neuroinflammatory signaling between parenchymal and meningeal cells in migraine headache., PMID:39080518
Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309., PMID:38780416
Human Pannexin 1 Channel is NOT Phosphorylated by Src Tyrosine Kinase at Tyr199 and Tyr309., PMID:38168229
Pannexin 1 Modulates Angiogenic Activities of Human Endothelial Colony-Forming Cells Through IGF-1 Mechanism and Is a Marker of Senescence., PMID:37589139
Purinergic 2X 4 (P2X4), but not P2X7, receptors increase cytosolic [Ca2+] and stimulate mucin secretion in rat conjunctival goblet cells to maintain ocular surface health., PMID:37580003
ER-resident STIM1/2 couples Ca2+ entry by NMDA receptors to pannexin-1 activation., PMID:36037373
Differential Action of Connexin Hemichannel and Pannexin Channel Therapeutics for Potential Treatment of Retinal Diseases., PMID:33578721
Extracellular ATP: A Feasible Target for Cancer Therapy., PMID:33212982
Developmental studies on the acquisition of perception conducting pathways via TRP channels in rat molar odontoblasts using immunohistochemistry and RT-qPCR., PMID:31848975
A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function., PMID:31263420
Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane., PMID:30814251
Pannexin 1 Channels Contribute to IL-1β Expression via NLRP3/Caspase-1 Inflammasome in Aspergillus Fumigatus Keratitis., PMID:30793631
Pannexin-1 is involved in neuronal apoptosis and degeneration in experimental intracerebral hemorrhage in rats., PMID:29484398
The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin., PMID:29145453
Expression and localization of pannexin-1 and CALHM1 in porcine bladder and their involvement in modulating ATP release., PMID:28254749
Connexin Hemichannels: Methods for Dye Uptake and Leakage., PMID:27586664
Retinal glial responses to optic nerve crush are attenuated in Bax-deficient mice and modulated by purinergic signaling pathways., PMID:27126275
Pannexin-1 channels show distinct morphology and no gap junction characteristics in mammalian cells., PMID:26386583
External Dentin Stimulation Induces ATP Release in Human Teeth., PMID:26130258
Nitric oxide inhibits the pannexin 1 channel through a cGMP-PKG dependent pathway., PMID:25917852
Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion., PMID:25327779
Amplification of human platelet activation by surface pannexin-1 channels., PMID:24655807
Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice., PMID:23977027
Pannexin1 stabilizes synaptic plasticity and is needed for learning., PMID:23284764
Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel., PMID:22159995
The pannexin 1 channel activates the inflammasome in neurons and astrocytes., PMID:19416975
Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury., PMID:19401709
Regulation by P2X7: epithelial migration and stromal organization in the cornea., PMID:18502993
Pannexin1 and Pannexin2 expression in the developing and mature rat brain., PMID:16143426
For research use only. Not for human or drug use.
