Catalog No.
RHN14802
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Applications
IHC, WB
Target
Brain-enriched hyaluronan-binding protein, BEHAB, BCAN, Chondroitin sulfate proteoglycan 7, CSPG7, Brevican core protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
N294A/10
Note
For research use only.
Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms., PMID:7592978
Light and electron microscopical immunohistochemical localization of large proteoglycans in human tooth germs at the bell stage., PMID:9147073
The brain chondroitin sulfate proteoglycan brevican associates with astrocytes ensheathing cerebellar glomeruli and inhibits neurite outgrowth from granule neurons., PMID:9315899
Expression of a cleaved brain-specific extracellular matrix protein mediates glioma cell invasion In vivo., PMID:9502798
Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis., PMID:9536289
Versican V2 is a major extracellular matrix component of the mature bovine brain., PMID:9624174
Differential regulation of expression of hyaluronan-binding proteoglycans in developing brain: aggrecan, versican, neurocan, and brevican., PMID:9642104
Immunocytochemical localization and biochemical characterization of large proteoglycans in developing rat bone., PMID:9680765
The proteoglycan lectin domain binds sulfated cell surface glycolipids and promotes cell adhesion., PMID:10196237
Immunohistochemical evidence for the brevican-tenascin-R interaction: colocalization in perineuronal nets suggests a physiological role for the interaction in the adult rat brain., PMID:10414531
A peptide mimic of E-selectin ligand inhibits sialyl Lewis X-dependent lung colonization of tumor cells., PMID:10667600
Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member., PMID:10801887
Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R., PMID:11077416
Carbohydrate-protein interactions between HNK-1-reactive sulfoglucuronyl glycolipids and the proteoglycan lectin domain mediate neuronal cell adhesion and neurite outgrowth., PMID:11208904
Intact aggrecan and fragments generated by both aggrecanse and metalloproteinase-like activities are present in the developing and adult rat spinal cord and their relative abundance is altered by injury., PMID:11425904
Immunohistochemical localization of large chondroitin sulphate proteoglycan in porcine gingival epithelia., PMID:11778745
Bral1, a brain-specific link protein, colocalizing with the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems., PMID:11817897
Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats., PMID:12379262
Limited growth of severed CNS axons after treatment of adult rat brain with hyaluronidase., PMID:12478611
Region and lamina-specific distribution of extracellular matrix proteoglycans, hyaluronan and tenascin-R in the mouse hippocampal formation., PMID:12954529
Lesion-induced differential expression and cell association of Neurocan, Brevican, Versican V1 and V2 in the mouse dorsal root entry zone., PMID:15896911
Localized gene expression of axon guidance molecules in neuronal co-cultures., PMID:16935349
Differential expression of several molecules of the extracellular matrix in functionally and developmentally distinct regions of rat spinal cord., PMID:17036229
Neurocan contributes to the molecular heterogeneity of the perinodal ECM., PMID:21566336
Alterations in chondroitin sulfate proteoglycan expression occur both at and far from the site of spinal contusion injury., PMID:21952042
Neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in Alzheimer's disease., PMID:22961619
Proteoglycan expression in normal human prostate tissue and prostate cancer., PMID:23691363
Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity., PMID:25225099
Molecular composition and expression pattern of the extracellular matrix in a mossy fiber-generating precerebellar nucleus of rat, the prepositus hypoglossi., PMID:25817362
Regulation of oligodendrocyte precursor maintenance by chondroitin sulphate glycosaminoglycans., PMID:26454153
Sensory experience-dependent formation of perineuronal nets and expression of Cat-315 immunoreactive components in the mouse somatosensory cortex., PMID:28495333
Heparan sulfate proteoglycans (HSPGs) and chondroitin sulfate proteoglycans (CSPGs) function as endocytic receptors for an internalizing anti-nucleic acid antibody., PMID:29085061
Neuroanatomical characterization of perineuronal net components in the human cochlear nucleus and superior olivary complex., PMID:30025262
The CNS-specific proteoglycan, brevican, and its ADAMTS4-cleaved fragment show differential serological levels in Alzheimer's disease, other types of dementia and non-demented controls: A cross-sectional study., PMID:32559242
For research use only. Not for human or drug use.
