Catalog No.
PHG07501
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PTPN11 (Met1-Arg593).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Tyrosine-protein phosphatase non-receptor type 11,Protein-tyrosine phosphatase 1D,PTP-2C,Shp2,SHP-2,SH-PTP3,Protein-tyrosine phosphatase 2C,PTP2C,PTP-1D,PTPN11,SHPTP2,SH-PTP2
Purification
Purified by antigen affinity column.
Accession
Q06124
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Siglec6 CAR T cells suppressed progression of AML via inhibiting Siglec6 and SHP2 induced Src and ERK signaling activation., PMID:40436895
Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312., PMID:40304209
Ras-MAPK pathway in patients with lupus nephritis., PMID:40102014
Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves' disease through integrated serum metabolomics and network pharmacology with molecular docking techniques., PMID:39950029
T Lymphocyte-Specific Deletion of SHP1 and SHP2 Promotes Activation-Induced Cell Death of CD4+ T Cells and Impairs Antitumor Response., PMID:39803505
Neuropathology and epilepsy surgery - 2024 update., PMID:38532826
Shp2 Deficiency in Kupffer Cells and Hepatocytes Aggravates Hepatocarcinogenesis by Recruiting Non-Kupffer Macrophages., PMID:36828281
Early Triple-Negative Breast Cancers in a Singapore Cohort Exhibit High PIK3CA Mutation Rates Associated With Low PD-L1 Expression., PMID:36788078
Endocrine system involvement in patients with RASopathies: A case series., PMID:36483002
GH Responsiveness in Children With Noonan Syndrome Compared to Turner Syndrome., PMID:34858328
Genomic data from NSCLC tumors reveals correlation between SHP-2 activity and PD-L1 expression and suggests synergy in combining SHP-2 and PD-1/PD-L1 inhibitors., PMID:34437586
Acute disseminated encephalomyelitis in a patient with Noonan syndrome: A rare autoinflammatory complication or coincidence?, PMID:34242782
SHP2 Targets ITK Downstream of PD-1 to Inhibit T Cell Function., PMID:33624224
Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine., PMID:33212364
Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling., PMID:33046519
Angiogenic and Immune-Related Biomarkers and Outcomes Following Axitinib/Pembrolizumab Treatment in Patients with Advanced Renal Cell Carcinoma., PMID:32816890
Bacteroides fragilis alleviates the symptoms of lupus nephritis via regulating CD1d and CD86 expressions in B cells., PMID:32721450
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2., PMID:32437509
Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors., PMID:32391629
Leukocyte immunoglobulin-like receptor B4 protects against cardiac hypertrophy via SHP-2-dependent inhibition of the NF-κB pathway., PMID:32280997
1H, 13C, 15N chemical shift assignments of SHP2 SH2 domains in complex with PD-1 immune-tyrosine motifs., PMID:32236803
Identification, recombinant expression and immunological study of Lja-SHP2 in Lampetra japonica., PMID:32102775
Shp2 activation in bone marrow microenvironment mediates the drug resistance of B-cell acute lymphoblastic leukemia through enhancing the role of VCAM-1/VLA-4., PMID:31978797
PTPN11 (SHP2) Is Indispensable for Growth Factors and Cytokine Signal Transduction During Bovine Oocyte Maturation and Blastocyst Development., PMID:31635340
Identification and Characterization of Post-activated B Cells in Systemic Autoimmune Diseases., PMID:31616406
Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy., PMID:31189114
Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma., PMID:30742119
Genomic alterations associated with HER2+ breast cancer risk and clinical outcome in response to trastuzumab., PMID:30535550
LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration., PMID:30333625
Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis., PMID:29891536
SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo., PMID:29808006
Association between single-nucleotide polymorphisms and adverse events in nivolumab-treated non-small cell lung cancer patients., PMID:29695768
Too many targets, not enough patients: rethinking neuroblastoma clinical trials., PMID:29632319
Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor., PMID:29282323
Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity., PMID:28578388
Targeted nanoconjugate co-delivering siRNA and tyrosine kinase inhibitor to KRAS mutant NSCLC dissociates GAB1-SHP2 post oncogene knockdown., PMID:27530552
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus., PMID:27183387
Rare Helicobacter pylori Infection May Explain Low Stomach Cancer Incidence: Ecological Observations in Bali, Indonesia., PMID:27039823
Changes in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes., PMID:27025927
The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function., PMID:26956486
SIRPα1-SHP2 Interaction Regulates Complete Freund Adjuvant-Induced Inflammatory Pain via Src-Dependent GluN2B Phosphorylation in Rats., PMID:26720617
Expression and clinical significance of tyrosine phosphatase SHP2 in thyroid carcinoma., PMID:26622699
NOX4-dependent Hydrogen peroxide promotes shear stress-induced SHP2 sulfenylation and eNOS activation., PMID:26427883
CD99 inhibits CD98-mediated β1 integrin signaling through SHP2-mediated FAK dephosphorylation., PMID:26172215
Do Genetic Susceptibility Variants Associate with Disease Severity in Early Active Rheumatoid Arthritis?, PMID:25979711
STAT1-Induced HLA Class I Upregulation Enhances Immunogenicity and Clinical Response to Anti-EGFR mAb Cetuximab Therapy in HNC Patients., PMID:25972070
Irreversible dual inhibitory mode: the novel Btk inhibitor PLS-123 demonstrates promising anti-tumor activity in human B-cell lymphoma., PMID:25944695
The Killer Cell Ig-like Receptor 2DL4 Expression in Human Mast Cells and Its Potential Role in Breast Cancer Invasion., PMID:25735953
Rapidly progressive hypertrophic cardiomyopathy in an infant with Noonan syndrome with multiple lentigines: palliative treatment with a rapamycin analog., PMID:25708222
Autoimmune liver disease in Noonan Syndrome., PMID:25595571
For research use only. Not for human or drug use.
