Anti-PTK2 Polyclonal Antibody

Catalog No.

PHG04701

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PTK2 (Gly798-Ala1041).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

p125FAK,pp125FAK,PPP1R71,Protein-tyrosine kinase 2,FADK 1,FAK1,Focal adhesion kinase 1,FAK,PTK2,Focal adhesion kinase-related nonkinase,FRNK,Protein phosphatase 1 regulatory subunit 71

Purification

Purified by antigen affinity column.

Accession

Q05397

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Deciphering melanophagy: role of the PTK2-ITCH-MLANA-OPTN cascade on melanophagy in melanocytes., PMID:39477686

Targeted delivery of FAK siRNA by engineered exosomes to reverse cetuximab resistance via activating paraptosis in colon cancer., PMID:38960944

Phosphohistidine signaling promotes FAK-RB1 interaction and growth factor-independent proliferation of esophageal squamous cell carcinoma., PMID:36513743

Monitoring tumour resistance to the BRAF inhibitor combination regimen in colorectal cancer patients via circulating tumour DNA., PMID:36202008

Truncated O-Glycan-Bearing MUC16 Enhances Pancreatic Cancer Cells Aggressiveness via α4β1 Integrin Complexes and FAK Signaling., PMID:35628269

Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis., PMID:35467979

Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial Cell Functions and Angiogenesis., PMID:34551592

CD146 is a potential immunotarget for neuroblastoma., PMID:34464480

FAK inhibitor PF-431396 suppresses IgE-mediated mast cell activation and allergic inflammation in mice., PMID:34384759

Complement receptor 3 mediates Aspergillus fumigatus internalization into alveolar epithelial cells with the increase of intracellular phosphatidic acid by activating FAK., PMID:34338598

Anti-GPR56 monoclonal antibody potentiates GPR56-mediated Src-Fak signaling to modulate cell adhesion., PMID:33837725

C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin αv., PMID:33420364

Lidocaine inhibits the metastatic potential of ovarian cancer by blocking NaV 1.5-mediated EMT and FAK/Paxillin signaling pathway., PMID:33280262

Protein profile of ear auricle cartilage and the important role of ITGB1/PTK2 in microtia., PMID:32896350

Specific inhibition of FAK signaling attenuates subchondral bone deterioration and articular cartilage degeneration during osteoarthritis pathogenesis., PMID:32324278

EM2D9, A monoclonal antibody against integrin α5β1, has potent antitumor activity on endometrial cancer in vitro and in vivo., PMID:32142917

VE-cadherin fusion protein substrate enhanced the vasculogenic mimicry capability of hepatocellular carcinoma cells., PMID:32016269

Protein tyrosine kinase 2: a novel therapeutic target to overcome acquired EGFR-TKI resistance in non-small cell lung cancer., PMID:31791326

Paracrine signalling of AGR2 stimulates RhoA function in fibroblasts and modulates cell elongation and migration., PMID:31710263

Targeting of stromal versican by miR-144/199 inhibits multiple myeloma by downregulating FAK/STAT3 signalling., PMID:31532704

Mast cell chymase in synovial fluid of collagen-induced-arthritis rats regulates gelatinase release and promotes synovial fibroblasts proliferation via FAK/p21 signaling pathway., PMID:31036322

Arecoline Promotes Migration of A549 Lung Cancer Cells through Activating the EGFR/Src/FAK Pathway., PMID:30925742

Squalamine blocks tumor-associated angiogenesis and growth of human breast cancer cells with or without HER-2/neu overexpression., PMID:30771431

TIMP-1 promotes hypermigration of Toxoplasma-infected primary dendritic cells via CD63-ITGB1-FAK signaling., PMID:30635444

Pro-Inflammatory Stimuli Influence Expression of Intercellular Adhesion Molecule 1 in Human Anulus Fibrosus Cells through FAK/ERK/GSK3 and PKCδ Signaling Pathways., PMID:30585203

ADAM15 in Apoptosis Resistance of Synovial Fibroblasts: Converting Fas/CD95 Death Signals Into the Activation of Prosurvival Pathways by Calmodulin Recruitment., PMID:30003689

Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion., PMID:29903032

Lung squamous cell carcinoma cells express non-canonically glycosylated IgG that activates integrin-FAK signaling., PMID:29778566

Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing., PMID:29401709

Peiminine serves as an adriamycin chemosensitizer in gastric cancer by modulating the EGFR/FAK pathway., PMID:29328433

Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling., PMID:29222114

Involvement of integrin β1/FAK signaling in the analgesic effects induced by glial cell line-derived neurotrophic factor in neuropathic pain., PMID:29031858

Loss of the podocyte glucocorticoid receptor exacerbates proteinuria after injury., PMID:28852159

Endothelin-1 promotes vascular smooth muscle cell migration across the artery wall: a mechanism contributing to vascular remodelling and intimal hyperplasia in giant-cell arteritis., PMID:28606962

Binding of CIB1 to the αIIb tail of αIIbβ3 is required for FAK recruitment and activation in platelets., PMID:28542214

Genistein inhibits the growth and regulates the migration and invasion abilities of melanoma cells via the FAK/paxillin and MAPK pathways., PMID:28423510

Cyclic peptide *CRRETAWAC* attenuates fibronectin-induced cytokine secretion of human airway smooth muscle cells by inhibiting FAK and p38 MAPK., PMID:28402030

Dentin sialoprotein facilitates dental mesenchymal cell differentiation and dentin formation., PMID:28331230

Aggretin Venom Polypeptide as a Novel Anti-angiogenesis Agent by Targeting Integrin alpha2beta1., PMID:28252668

Transforming growth factor β induces bone marrow mesenchymal stem cell migration via noncanonical signals and N-cadherin., PMID:28213973

PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment., PMID:28103122

Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling., PMID:27519953

Overexpression of the miR-141/200c cluster promotes the migratory and invasive ability of triple-negative breast cancer cells through the activation of the FAK and PI3K/AKT signaling pathways by secreting VEGF-A., PMID:27484639

FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal., PMID:27064283

HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors., PMID:26984758

Inhibition of adhesion, migration and of α5β1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A., PMID:26961176

Improving gastric cancer preclinical studies using diverse in vitro and in vivo model systems., PMID:26955870

The mechanisms of substance P-mediated migration of bone marrow-derived mesenchymal stem cell-like ST2 cells., PMID:26936322

The CXCL10/CXCR3 axis promotes cardiac microvascular endothelial cell migration via the p38/FAK pathway in a proliferation-independent manner., PMID:26835911

A phagocytosis assay for oxidized low-density lipoprotein versus immunoglobulin G-coated microbeads in human U937 macrophages., PMID:26800863

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