Catalog No.
RHG74701
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
RecQ protein-like 2, DNA helicase, RecQ-like type 3, RecQ3, Werner syndrome ATP-dependent helicase, RECQ3, RECQL2, Exonuclease WRN, WRN
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
N260/17
Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model., PMID:38795389
Werner helicase is required for proliferation and DNA damage repair in multiple myeloma., PMID:36515823
Werner syndrome presenting as early-onset diabetes: A case report., PMID:34564935
Characterization of G-quadruplex antibody reveals differential specificity for G4 DNA forms., PMID:33084858
WRN-Mutated Colorectal Cancer Is Characterized by a Distinct Genetic Phenotype., PMID:32455893
Custom DNA Microarrays Reveal Diverse Binding Preferences of Proteins and Small Molecules to Thousands of G-Quadruplexes., PMID:32216326
Functional conservation of RecQ helicase BLM between humans and Drosophila melanogaster., PMID:31772289
Flow Cytometry as a Diagnostic Tool in Primary and Secondary Immune Deficiencies., PMID:31668272
Reprogramming of Human Peripheral Blood Mononuclear Cell (PBMC) from a patient suffering of a Werner syndrome resulting in iPSC line (REGUi003-A) maintaining a short telomere length., PMID:31404747
Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer., PMID:31375513
Prevention of mother-to-child transmission of hepatitis B virus: a phase III, placebo-controlled, double-blind, randomized clinical trial to assess the efficacy and safety of a short course of tenofovir disoproxil fumarate in women with hepatitis B virus e-antigen., PMID:27506549
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice., PMID:26447695
BLM helicase facilitates telomere replication during leading strand synthesis of telomeres., PMID:26195664
WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome., PMID:25503078
Werner complex deficiency in cells disrupts the Nuclear Pore Complex and the distribution of lamin B1., PMID:24050918
Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching., PMID:23254285
Triplex DNA-binding proteins are associated with clinical outcomes revealed by proteomic measurements in patients with colorectal cancer., PMID:22682314
The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling., PMID:22002307
ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery., PMID:20802463
Fibroblasts from Werner syndrome patients: cancer cells derived by experimental introduction of oncogenes maintain malignant properties despite entering crisis., PMID:20043098
DNA-dependent protein kinase (DNA-PK)-dependent cisplatin-induced loss of nucleolar facilitator of chromatin transcription (FACT) and regulation of cisplatin sensitivity by DNA-PK and FACT., PMID:19372586
Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome., PMID:17498979
The Werner syndrome protein is required for recruitment of chromatin assembly factor 1 following DNA damage., PMID:17173071
Significant elevation of IgG anti-WRN (RecQ3 RNA/DNA helicase) antibody in systemic sclerosis., PMID:16906373
Formation of a nuclear complex containing the p53 tumor suppressor, YB-1, and the Werner syndrome gene product in cells treated with UV light., PMID:16584908
Expression of Werner and Bloom syndrome genes is differentially regulated by in vitro HIV-1 infection of peripheral blood mononuclear cells., PMID:15498034
Radiosensitivity is predicted by DNA end-binding complex density, but not by nuclear levels of band components., PMID:15450732
RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway., PMID:15317757
Werner protein stimulates topoisomerase I DNA relaxation activity., PMID:14612507
DNA damage modulates nucleolar interaction of the Werner protein with the AAA ATPase p97/VCP., PMID:12937274
Characterization of the slow-growth phenotype of S. cerevisiae Whip/Mgs1 Sgs1 double deletion mutants., PMID:12509289
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases., PMID:12181313
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53., PMID:12080066
Diagnosis of Werner syndrome by immunoblot analysis., PMID:11952711
Functional interaction of p53 and BLM DNA helicase in apoptosis., PMID:11399766
Evidence for a replication function of FFA-1, the Xenopus orthologue of Werner syndrome protein., PMID:11238454
Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death., PMID:11154689
Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1., PMID:10806190
Identification of phage antibodies toward the Werner protein by selection on Western blots., PMID:10726750
Localization of the Bloom syndrome helicase to punctate nuclear structures and the nuclear matrix and regulation during the cell cycle: comparison with the Werner's syndrome helicase., PMID:10569803
Expression of the BLM gene in human haematopoietic cells., PMID:10540192
Immunological diagnosis of Werner syndrome by down-regulated and truncated gene products., PMID:10543396
The Werner syndrome protein is involved in RNA polymerase II transcription., PMID:10436020
Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding., PMID:10325426
Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization., PMID:9885239
Werner helicase is localized to transcriptionally active nucleoli of cycling cells., PMID:9683536
Nucleolar localization of the Werner syndrome protein in human cells., PMID:9618508
Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants., PMID:9271578
For research use only. Not for human or drug use.
