Catalog No.
PHF91801
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human DHODH (Thr31-Arg395).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Dihydroorotate oxidase,Dihydroorotate dehydrogenase (quinone),mitochondrial,DHODH,DHOdehase
Purification
Purified by antigen affinity column.
Accession
Q02127
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance., PMID:36285442
Safety and Efficacy of Vidofludimus Calcium in Patients Hospitalized with COVID-19: A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial., PMID:36242741
Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19., PMID:36041646
Genetic and Clinical Factors Associated with Olokizumab Treatment in Russian Patients with Rheumatoid Arthritis., PMID:35455757
Genetic Factors of Predisposition and Clinical Characteristics of Rheumatoid Arthritis in Russian Patients., PMID:34070522
Second-generation immunotherapeutics in multiple sclerosis: can we discard their precursors?, PMID:33248250
Potential Anti-SARS-CoV-2 Therapeutics That Target the Post-Entry Stages of the Viral Life Cycle: A Comprehensive Review., PMID:32993173
Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells., PMID:29467002
Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors., PMID:26593978
Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii., PMID:22580100
Region-specific distribution of dihydroorotate dehydrogenase in the rat central nervous system points to pyrimidine de novo synthesis in neurons., PMID:20544541
Suppression of immunoglobulin production by a novel dihydroorotate dehydrogenase inhibitor, S-2678., PMID:18834876
Dihydroorotate dehydrogenase arises from novel fused gene product with aspartate carbamoyltransferase in Bodo saliens., PMID:17475213
Immunosuppression: today, tomorrow, and withdrawal., PMID:16850369
Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD., PMID:15890648
Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells., PMID:15571246
Leflunomide for the treatment of rheumatoid arthritis., PMID:12783594
Drosophila melanogaster dihydroorotate dehydrogenase: the N-terminus is important for biological function in vivo but not for catalytic properties in vitro., PMID:12213251
In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine., PMID:12100469
Detection and location of the enzymes of de novo pyrimidine biosynthesis in mammalian spermatozoa., PMID:12052230
Suppression of experimental autoimmune neuritis by leflunomide., PMID:11522581
Aromatic quinolinecarboxamides as selective, orally active antibody production inhibitors for prevention of acute xenograft rejection., PMID:11384243
New disease modifying agents in adult rheumatoid arthritis., PMID:11379415
Anti-arthritic effects of KF20444, a new immunosuppressive compound inhibiting dihydroorotate dehydrogenase, on rat collagen-induced arthritis., PMID:11235018
Leflunomide, mycophenolic acid and matrix metalloproteinase inhibitors., PMID:10646484
Oral administration of leflunomide (HWA486) results in prominent suppression of immunoglobulin E formation in a rat type 1 allergy model., PMID:9918599
Pyrazole bioisosteres of leflunomide as B-cell immunosuppressants for xenotransplantation and chronic rejection: scope and limitations., PMID:9719606
Regulation of alloreactivity in the popliteal lymph node assay by the new immunosuppressants: malononitrilamides., PMID:9665036
Dihydroorotate dehydrogenase. Profile of a novel target for antiproliferative and immunosuppressive drugs., PMID:9598119
Control of lymphoproliferative and autoimmune disease in MRL-lpr/lpr mice by brequinar sodium: mechanisms of action., PMID:9353408
Rat dihydroorotate dehydrogenase: isolation of the recombinant enzyme from mitochondria of insect cells., PMID:9179295
The alloreactivity in the popliteal lymph node (PLN) assay is regulated by malononitrilamides (MNAs)., PMID:9506317
Anti-peptide immunoglobulins from rabbit and chicken eggs recognise recombinant human dihydroorotate dehydrogenase and a 44-kDa protein from rat liver mitochondria., PMID:8612635
Purification, characterization and localization of mitochondrial dihydroorotate dehydrogenase in Plasmodium falciparum, human malaria parasite., PMID:7727509
Studies on the effect of CL 306,293, a substituted quinoline carboxylic acid, on the clinical disease induced in mice with LP-BM5 virus., PMID:8384434
Molecular recognition in applied enzyme chemistry., PMID:1765126
Intracellular location of the multidomain protein CAD in mammalian cells., PMID:2903106
Antigenic architecture of membrane vesicles from Escherichia coli., PMID:218621
Immunochemical analysis of inner and outer membranes of Escherichia coli by crossed immunoelectrophoresis., PMID:338583
For research use only. Not for human or drug use.
