Anti-P2X purinoceptor 3 Antibody (N362/34)

Catalog No.

RHF16603

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

Purinergic receptor, P2X3, ATP receptor, P2RX3, P2X purinoceptor 3

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Applications

IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

N362/34

Impaired LPS Signaling in Macrophages Overexpressing the P2X7 C-Terminal Domain or Anti-P2X7 C-Terminal Domain Intrabody., PMID:39940947

Evidence of an excitatory purinergic innervation in mouse corpus cavernosum smooth muscle., PMID:39234981

The P2X7 Receptor is a Master Regulator of Microparticle and Mitochondria Exchange in Mouse Microglia., PMID:38984997

Oxidized ATP Suppresses B Lymphocyte Activity to Attenuate Antibody-mediated Rejection of Kidney Allografts in Mice., PMID:38946027

Microbiota-Parasite Interaction: Implication of Secretory Immunoglobulin A and P2X7 Receptor Signaling., PMID:38409828

Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety., PMID:38395698

Bone marrow plasma cells require P2RX4 to sense extracellular ATP., PMID:38355795

Extracellular vesicles from oral mucosa stem cells promote lipid raft formation in human microglia through TLR4, P2X4R, and αVβ3/αVβ5 signaling pathways., PMID:38100213

Purinergic 2X 4 (P2X4), but not P2X7, receptors increase cytosolic [Ca2+] and stimulate mucin secretion in rat conjunctival goblet cells to maintain ocular surface health., PMID:37580003

The shed P2X7 receptor is an index of adverse clinical outcome in COVID-19 patients., PMID:37215142

NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload., PMID:36440584

Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway., PMID:35065198

Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions., PMID:34996944

The P2X7 purinergic receptor in intervertebral disc degeneration., PMID:34668208

Targeting Purinergic Receptor P2RX1 Modulates Intestinal Microbiota and Alleviates Inflammation in Colitis., PMID:34354708

Immunohistochemical evidence of P2X7R, P2X4R and CaMKK2 in pyramidal neurons of frontal cortex does not align with Alzheimer's disease., PMID:33838119

Update of P2X receptor properties and their pharmacology: IUPHAR Review 30., PMID:33125712

Structure-based engineering of anti-GFP nanobody tandems as ultra-high-affinity reagents for purification., PMID:32277083

Production, characterization, and application of a monoclonal antibody specific for the extracellular domain of human P2X7R., PMID:31930453

Activation of P2X7R- NLRP3 pathway in Retinal microglia contribute to Retinal Ganglion Cells death in chronic ocular hypertension (COH)., PMID:31445901

MiR-187-3p mimic alleviates ischemia-reperfusion-induced pain hypersensitivity through inhibiting spinal P2X7R and subsequent mature IL-1β release in mice., PMID:31100367

Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine., PMID:31019207

P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP., PMID:31016551

The ATP-gated P2X1 ion channel contributes to the severity of antibody-mediated Transfusion-Related Acute Lung Injury in mice., PMID:30914724

Antibodies and venom peptides: new modalities for ion channels., PMID:30728472

Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis., PMID:30718392

Calcium signalling in T cells., PMID:30622345

Purinoceptor expression in hepatocellular virus (HCV)-induced and non-HCV hepatocellular carcinoma: an insight into the proviral role of the P2X4 receptor., PMID:30343397

P2X1 Receptors Amplify FcγRIIa-Induced Ca2+ Increases and Functional Responses in Human Platelets., PMID:29443373

Expression of purinergic P2X7 receptors in subpopulations of peripheral blood mononuclear cells in early-stage of chronic kidney disease., PMID:29375053

P2X7 receptor mediates NLRP3-dependent IL-1β secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells., PMID:29291748

Corneal Neovascularization: A Combined Approach of Bevacizumab and Suramin Showed Increased Antiangiogenic Effect Through Downregulation of BFGF and P2X2., PMID:29265937

Purinergic 2X7 receptor activation regulates WNT signaling in human mandibular-derived osteoblasts., PMID:28549259

TNF-α Mediates the Intrinsic and Extrinsic Pathway in Propofol-Induced Neuronal Apoptosis Via PI3K/Akt Signaling Pathway in Rat Prefrontal Cortical Neurons., PMID:28540664

CD73 Controls Extracellular Adenosine Generation in the Trigeminal Nociceptive Nerves., PMID:28530470

Ligation of CD40 in Human Müller Cells Induces P2X7 Receptor-Dependent Death of Retinal Endothelial Cells., PMID:27893093

Characterization of 11C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation., PMID:27765863

P2X7 nucleotide receptor signaling potentiates the Wnt/β-catenin pathway in cells of the osteoblast lineage., PMID:27206526

Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies., PMID:27129281

LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X7 receptor in dorsal root ganglia., PMID:27107575

Co-localization of Pirt protein and P2X2 receptors in the mouse enteric nervous system., PMID:27105971

Lack of functional P2X7 receptor aggravates brain edema development after middle cerebral artery occlusion., PMID:27048203

Increased levels of extracellular ATP in glaucomatous retinas: Possible role of the vesicular nucleotide transporter during the development of the pathology., PMID:26392744

Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy., PMID:26349656

The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells., PMID:25692702

ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer's patches to promote host-microbiota mutualism., PMID:25464855

Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia., PMID:25127716

Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy., PMID:25003238

Vascular smooth muscle cells from small human omental arteries express P2X1 and P2X4 receptor subunits., PMID:24845338

Targeted delivery of a SNARE protease to sensory neurons using a single chain antibody (scFv) against the extracellular domain of P2X(3) inhibits the release of a pain mediator., PMID:24844294

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