Anti-CDK5 Polyclonal Antibody

Catalog No.

PHF82201

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CDK5 (Asp92-Gln273).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Cell division protein kinase 5,Cyclin-dependent-like kinase 5,TPKII catalytic subunit,Serine/threonine-protein kinase PSSALRE,Tau protein kinase II catalytic subunit,CDK5,CDKN5

Purification

Purified by antigen affinity column.

Accession

Q00535

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

CDK5 Deficiency Does not Impair Neuronal Differentiation of Human Induced Pluripotent Stem Cells but Affects Neurite Outgrowth., PMID:38937422

Self-Assembled PD-L1 Downregulator to Boost Photodynamic Activated Tumor Immunotherapy Through CDK5 Inhibition., PMID:38856024

CRISPR-based gene expression platform for precise regulation of bladder cancer., PMID:38724931

Antibody-free time-resolved terbium luminescence assays designed for cyclin-dependent kinase 5 (CDK5)., PMID:38712268

Targeting Abnormal Tau Phosphorylation for Alzheimer's Therapeutics., PMID:38350636

Shortwave radiation-induced reproductive organ damage in male rats by enhanced expression of molecules associated with the calpain/Cdk5 pathway and oxidative stress., PMID:38155529

CDK5 destabilizes PD-L1 via chaperon-mediated autophagy to control cancer immune surveillance in hepatocellular carcinoma., PMID:38007240

Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid Carcinoma., PMID:37398342

VEGF-A in serum protects against memory impairment in APP/PS1 transgenic mice by blocking neutrophil infiltration., PMID:37280283

Extracellular CIRP Induces Calpain Activation in Neurons via PLC-IP3-Dependent Calcium Pathway., PMID:36853429

In vivo analysis of the phosphorylation of tau and the tau protein kinases Cdk5-p35 and GSK3β by using Phos-tag SDS-PAGE., PMID:35430389

Relationship between plasma cyclin-dependent kinase 5 levels and local immunoglobulin levels in patients with nasal polyps., PMID:34933723

Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution., PMID:34848712

Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma., PMID:34130052

Adhesion GPCR Latrophilin-2 Specifies Cardiac Lineage Commitment through CDK5, Src, and P38MAPK., PMID:33798451

Binding of gephyrin to microtubules is regulated by its phosphorylation at Ser270., PMID:33796945

AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation., PMID:33291667

Lnc-ATG9B-4 aggravates progress of hepatocellular carcinoma through cell proliferation and migration by upregulating CDK5., PMID:33023330

Experimental evidence for alpha enolase as one potential autoantigen in the pathogenesis of both autoimmune thyroiditis and its related encephalopathy., PMID:32442899

CDK5 Activates Hippo Signaling to Confer Resistance to Radiation Therapy Via Upregulating TAZ in Lung Cancer., PMID:32407930

Fingolimod Modulates Dendritic Architecture in a BDNF-Dependent Manner., PMID:32349283

Cdk5 Inhibitory Peptide Prevents Loss of Neurons and Alleviates Behavioral Changes in p25 Transgenic Mice., PMID:32144987

Cdk5 knocking out mediated by CRISPR-Cas9 genome editing for PD-L1 attenuation and enhanced antitumor immunity., PMID:32082979

Vps35 Deficiency Impairs Cdk5/p35 Degradation and Promotes the Hyperphosphorylation of Tau Protein in Retinal Ganglion Cells., PMID:31995153

Landscape of PD-1/PD-L1 Regulation and Targeted Immunotherapy., PMID:30266108

The HU177 Collagen Epitope Controls Melanoma Cell Migration and Experimental Metastasis by a CDK5/YAP-Dependent Mechanism., PMID:30118657

Phosphorylation of synaptic GTPase-activating protein (synGAP) by polo-like kinase (Plk2) alters the ratio of its GAP activity toward HRas, Rap1 and Rap2 GTPases., PMID:30049443

β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals., PMID:30016458

Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy., PMID:29467609

Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretion., PMID:29325547

Chiglitazar Preferentially Regulates Gene Expression via Configuration-Restricted Binding and Phosphorylation Inhibition of PPARγ., PMID:29056962

Downregulated apoptosis and autophagy after anti-Aβ immunotherapy in Alzheimer's disease., PMID:29027727

Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species., PMID:28981754

TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage ischemic stroke of adult rats., PMID:27998781

Experimental approaches for investigation of aminoacyl tRNA synthetase phosphorylation., PMID:27729295

Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins., PMID:27486244

Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis., PMID:27479491

Sunitinib activates Axl signaling in renal cell cancer., PMID:26815723

Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis., PMID:26555036

NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas., PMID:26340530

Aberrant expression of CDK5 infers poor outcomes for nasopharyngeal carcinoma patients., PMID:26339373

p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing., PMID:25864429

Caloric restriction mimetic 2-deoxyglucose maintains cytoarchitecture and reduces tau phosphorylation in primary culture of mouse hippocampal pyramidal neurons., PMID:25678460

Proteomic analysis of cerebrospinal fluid in Alzheimer's disease: wanted dead or alive., PMID:25428253

Clinical study of the novel cyclin-dependent kinase inhibitor dinaciclib in combination with rituximab in relapsed/refractory chronic lymphocytic leukemia patients., PMID:25217392

Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex., PMID:25189171

Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser(116) signaling cascade in endothelial cells and mice., PMID:25150199

Cdk5 phosphorylation of EFhd2 at S74 affects its calcium binding activity., PMID:24917152

Regulation of Sox6 by cyclin dependent kinase 5 in brain., PMID:24662752

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration., PMID:24548080

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