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Belantamab mafodotin (ADC)

Catalog #:   DHF92499 Specific References (50) DATASHEET
Applications: Research Grade Biosimilar
Overview

Catalog No.

DHF92499

Description

Belantamab mafodotin is an ADC consisting of a BCMA-directed antibody and McMMAF used for the study of multiple myeloma.

Species reactivity

Human

Clonality

Monoclonal

Target

BCMA

Concentration

7.98 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SEC.

Purification

Purified by Ion Exchange Chromatography.

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

100 mM Pro-Ac, 20 mM Arg, pH 5.0

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

GSK2857916, J6M0-mcMMAF

Clone ID

Belantamab mafodotin

Data Image
  • SDS-PAGE
    SDS PAGE for Belantamab mafodotin
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

PMDA regulatory update on approval and revision of the precautions for use of anticancer drugs; approval of belantamab mafodotin for multiple myeloma, asciminib for leukemia, osimertinib for lung cancer, amivantamab for lung cancer, and pembrolizumab for pleural mesothelioma in Japan., PMID:40481943

Real-world characteristics and outcomes of patients with multiple myeloma treated with belantamab mafodotin: a German claims data study., PMID:40448822

Population Pharmacokinetics for Belantamab Mafodotin Monotherapy and Combination Therapies in Patients with Relapsed/Refractory Multiple Myeloma., PMID:40447948

Practice-changing updates on multiple myeloma: highlights from the 2024 ASH annual meeting., PMID:40361170

Treatment Patterns, Efficacy, and Tolerability of Belantamab Mafodotin in Patients With Relapsed and/or Refractory Multiple Myeloma: A Real-World Analysis., PMID:40348718

Characterization of Belantamab Mafodotin-Induced Corneal Changes in Patients With Multiple Myeloma., PMID:40338596

Corneal Findings in Patients Treated with Belantamab Mafodotin: A Prospective Case Series Focusing on Corneal Nerves., PMID:40327294

Belantamab Mafodotin Monotherapy for Multiply-Relapsed Myeloma: A Retrospective Study From the United Kingdom and the Republic of Ireland., PMID:40308262

HSR25-172: Meta-Analysis of Phase 3 Randomized Controlled Trials to Evaluate the Incidence of Infectious Adverse Events in Patients With Relapsed/Refractory Multiple Myeloma Treated With Belantamab Mafodotin., PMID:40154473

HSR25-143: Meta-Analysis of Phase 3 Randomized Controlled Trials to Evaluate the Incidence of Systemic Toxicities in Patients With Relapsed/Refractory Multiple Myeloma Treated With Belantamab Mafodotin., PMID:40154424

Belantamab Mafodotin Plus Proteasome Inhibition Efficacy Versus Comparators in Early Relapsed Myeloma: A Systematic Review and Network Meta-Analysis., PMID:40143674

Correction: The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development., PMID:40140348

Current Treatment Strategies for Multiple Myeloma at First Relapse., PMID:40095642

Unveiling cardiovascular and respiratory toxicities with monoclonal antibodies in multiple myeloma: disproportionality analysis from the FDA Adverse Event Reporting System., PMID:40095047

Novelties on Multiple Myeloma from the Main 2024 Hematology Conferences., PMID:40084104

A real-world experience of efficacy and safety of belantamab mafodotin in relapsed refractory multiple myeloma., PMID:40064854

Prior exposure to belantamab mafodotin influences outcomes with idecabtagene vicleucel in patients with multiple myeloma., PMID:39938011

The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development., PMID:39920159

Novel Treatment Options for Multiple Myeloma., PMID:39772633

Update on B-cell maturation antigen-directed therapies in AL amyloidosis., PMID:39748220

DREAMM-11, Part 2: Japanese phase I trial of belantamab mafodotin combination therapies in relapsed/refractory multiple myeloma., PMID:39718747

The Antibody Drug Conjugate, Belantamab-Mafodotin, in the Treatment of Multiple Myeloma: A Comprehensive Review., PMID:39664714

Focal and Segmental Glomerulosclerosis in a Multiple Myeloma Patient After Belantamab Mafodotin Therapy and Severe COVID-19 Infection: A Case Report., PMID:39482831

Neuropsychiatric Adverse Events with Monoclonal Antibodies Approved for Multiple Myeloma: An Analysis from the FDA Adverse Event Reporting System., PMID:39458907

Strengths and Weaknesses of Different Therapeutic Strategies for the Treatment of Patients with Multiple Myeloma Who Progress After the Frontline Use of Lenalidomide: A Narrative Review., PMID:39458188

Results from Arm A of Phase 1/2 DREAMM-6 trial: belantamab mafodotin with lenalidomide plus dexamethasone in patients with relapsed/refractory multiple myeloma., PMID:39433730

Belantamab mafodotin monotherapy for relapsed or refractory multiple myeloma: a real-world observational study in the United States., PMID:39415693

Belantamab Mafodotin, Bortezomib, and Dexamethasone for Multiple Myeloma. Reply., PMID:39383466

Belantamab Mafodotin, Bortezomib, and Dexamethasone for Multiple Myeloma., PMID:39383465

Belantamab Mafodotin in Relapsed/Refractory AL Amyloidosis: Real-World Multi-Center Experience and Review of the Literature., PMID:39357511

Preclinical Evaluation of STI-8811, a Novel Antibody-Drug Conjugate Targeting BCMA for the Treatment of Multiple Myeloma., PMID:39292169

Drug-Related Keratitis: A Real-World FDA Adverse Event Reporting System Database Study., PMID:39287587

How to rescue a DreaMM deferred …., PMID:39276768

Belantamab mafodotin, pomalidomide, and dexamethasone for triple class exposed/refractory relapsed multiple myeloma: a subgroup analysis of the ALGONQUIN trial., PMID:39261451

Ocular adverse events associated with antibody-drug conjugates in oncology: a pharmacovigilance study based on FDA adverse event reporting system (FAERS)., PMID:39228525

Matching-adjusted indirect comparison of talquetamab vs selinexor-dexamethasone and vs belantamab mafodotin in patients with relapsed/refractory multiple myeloma., PMID:39226081

The Role of Monoclonal Antibodies in the Treatment of Myeloma Kidney Disease., PMID:39204135

Dynamics of microcyst-like epithelial changes associated with Belantamab mafodotin therapy in a patient with multiple myeloma-a case report., PMID:39112495

A Belantamab Mafodotin Revival in Multiple Myeloma Therapy., PMID:39083777

Belantamab-mafodotin-associated keratopathy., PMID:39003154

Corneal Toxicity in Patients Treated by BELANTAMAB MAFODOTIN: How to Improve and Facilitate Patients Follow-Up Using Refractive Shift?, PMID:38976493

Belantamab mafodotin concentration-QTc relationships in patients with relapsed or refractory multiple myeloma from the DREAMM-1 and -2 studies., PMID:38924122

Visualization of Keratopathy Associated With the Antibody-Drug Conjugate Belantamab Mafodotin Using Infrared Imaging in Patients With Multiple Myeloma., PMID:38900711

Belantamab mafodotin in triple-refractory multiple myeloma patients: A retro-prospective observational study in Italy., PMID:38895069

Successful treatment with belantamab mafodotin in a heavily pretreated patient with multiple myeloma and liver extramedullary disease., PMID:38850573

Belantamab Mafodotin, Pomalidomide, and Dexamethasone in Multiple Myeloma., PMID:38828951

Belantamab Mafodotin, Bortezomib, and Dexamethasone for Multiple Myeloma., PMID:38828933

Clinical evaluation and determinants of response to HBI0101 (BCMA CART) therapy in relapsed/refractory multiple myeloma., PMID:38768428

Antigen escape as a shared mechanism of resistance to BCMA-directed therapies in multiple myeloma., PMID:38728378

Effectiveness and safety of belantamab mafodotin in patients with relapsed or refractory multiple myeloma in real-world setting: The ALFA study., PMID:38722078

Datasheet

Document Download

Belantamab mafodotin (ADC).pdf

 

$ 2540
Product specifications
1 mg 2540 5 mg 6360

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Belantamab mafodotin (ADC) [DHF92499]
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