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Sacituzumab govitecan (ADC)

Catalog #:   DHC43398 Specific References (50) DATASHEET
Applications: Research Grade Biosimilar
Overview

Catalog No.

DHC43398

Description

Sacituzumab govitecan is an ADC consisting of a TROP2-directed antibody and SN38 for the study of breast cancer.

Species reactivity

Human

Clonality

Monoclonal

Target

Trop2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SEC.

Purification

Purified by Ion Exchange Chromatography.

Applications

Research Grade Biosimilar

Form

Liquid

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

IMMU-132

Clone ID

Sacituzumab govitecan

Data Image
References

Advances in targeted therapy for triple-negative breast cancer: a review of key antigens and recent advances., PMID:40515614

The antibody-drug conjugate sacituzumab govitecan (IMMU-132) represents a potential novel therapeutic strategy in cholangiocarcinoma., PMID:40509933

A Meta-Analysis of Patient-Reported Outcomes of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Previously Treated HR+/HER- mBC Using Two Phase 3 (TROPiCS-02 and EVER-132-002) Trials., PMID:40507364

Advancing Antibody-Drug Conjugates: Precision Oncology Approaches for Breast and Pancreatic Cancers., PMID:40507272

Efficacy and Safety of TROP-2-Targeting Antibody-Drug Conjugate Treatment in Previously Treated Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Pooled Analysis of Reconstructed Patient Data., PMID:40507234

Comparative pharmacological analysis of fam-trastuzumab deruxtecan-nxki and sacituzumab govitecan-hziy: Two recently developed chemotherapies in the crucial battle against breast cancer., PMID:40502326

Synergistic strategies: ADC-PARP inhibitor combinations in triple-negative breast cancer therapy., PMID:40494034

Results of a phase 1/2 study of sacituzumab tirumotecan in patients with unresectable locally advanced or metastatic solid tumors refractory to standard therapies., PMID:40481574

Effectiveness of sacituzumab govitecan and management of neutropenia in patients with metastatic triple-negative breast cancer treated in real-world settings in the United States., PMID:40479864

Real-world clinical outcomes of sacituzumab govitecan after prior exposure to enfortumab vedotin in patients with metastatic urothelial carcinoma., PMID:40479863

The association of high body mass index with the safety and efficacy of sacituzumab govitecan in patients with metastatic triple-negative breast cancer from the ASCENT study., PMID:40460679

Mechanisms of resistance to antibody-drug conjugates in cancers., PMID:40460510

New Treatment Approaches for Triple-Negative Breast Cancer., PMID:40460322

Evaluation of sacituzumab govitecan for advanced/metastatic non-small cell lung cancer., PMID:40458070

Avelumab plus sacituzumab govitecan versus avelumab monotherapy as first-line maintenance treatment in patients with advanced urothelial carcinoma: JAVELIN Bladder Medley interim analysis., PMID:40456670

Sequential Antibody-Drug Conjugate Therapy in Patients With Metastatic Breast Cancer Treated With Sacituzumab Govitecan and Trastuzumab Deruxtecan., PMID:40440568

Last Resort? Rationale for Comprehensive Molecular Analysis in Treatment-Refractory R/M HNSCC: A Case Report of Remarkable Response to Sacituzumab Govitecan Following Molecular and Functional Characterization., PMID:40427091

ADCs and TCE in SCLC Therapy: The Beginning of a New Era?, PMID:40422520

Cost and Cost-Effectiveness of Treating Human Epidermal Growth Factor Receptor 2-Low Metastatic Breast Cancer., PMID:40397834

A Multicenter Real-Life Evaluation of Safety and Effectiveness of the Antibody-Drug Conjugate Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer., PMID:40387297

Update Breast Cancer 2024 Part 3 - Patients with Advanced Stage Breast Cancer., PMID:40386501

Progress of antibody-drug conjugates in the treatment of locally advanced or metastatic urothelial carcinoma: opportunities and challenges., PMID:40377724

Plain language summary of the EVOKE-01 study of sacituzumab govitecan vs docetaxel in patients with non-small cell lung cancer., PMID:40371894

[Translated article] Influence of the UGT1A1 gene polymorphism on treatment with sacituzumab govitecan. Narrative review., PMID:40368667

Decoding Clinical Trials in Metastatic Breast Cancer: Practical Insights for Optimal Therapy Sequencing., PMID:40367401

Delphi consensus on the management of adverse events in patients with metastatic triple-negative breast cancer treated with sacituzumab govitecan., PMID:40366333

The Clinical Outcomes and Safety of Sacituzumab Govitecan in Heavily Pretreated Metastatic Triple-Negative and HR+/HER2- Breast Cancer: A Multicenter Observational Study from Turkey., PMID:40361516

TROP2 expression and therapeutic targeting in uterine carcinosarcoma., PMID:40344963

Navigating antibody‒drug conjugates (ADCs): from metastatic to early breast cancer treatment strategies., PMID:40304863

MMP1-induced NF-κB activation promotes epithelial-mesenchymal transition and sacituzumab govitecan resistance in hormone receptor-positive breast cancer., PMID:40287412

[Diffuse interstitial lung disease induced by antibody-drug conjugates]., PMID:40263022

Antibody-Based Therapeutics in Small Cell Lung Cancer: A Narrative Review., PMID:40260055

Evaluation of Nectin-4 and Trop-2: Implications for Patient Outcomes and Therapy in Penile Cancer., PMID:40252843

Targeting Lung Cancer with Precision: The ADC Therapeutic Revolution., PMID:40238068

Multicenter retrospective cohort study of the sequential use of the antibody-drug conjugates (ADCs) trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) in patients with HER2-low metastatic breast cancer (MBC)., PMID:40234477

Antibody-drug conjugates in breast cancer treatment: resistance mechanisms and the role of therapeutic sequencing., PMID:40201309

Trop2-expression in primary vulvar squamous cell carcinoma., PMID:40184712

Safety and Tolerability of Concurrent Radiotherapy and Sacituzumab Govitecan in Metastatic Breast Cancer., PMID:40178882

Advances in adoptive cell therapies in small cell lung cancer., PMID:40160238

Toxicities and management strategies of emerging antibody-drug conjugates in breast cancer., PMID:40151551

Camptothein-Based Anti-Cancer Therapies and Strategies to Improve Their Therapeutic Index., PMID:40149365

Influence of the UGT1A1 gene polymorphism on treatment with sacituzumab govitecan. Narrative review., PMID:40140308

Q-TWiST Analysis of Sacituzumab Govitecan vs. Chemotherapy in Previously Treated Patients with HR+/HER2- Metastatic Breast Cancer., PMID:40136373

Correction to: Health-related quality of life with sacituzumab govitecan in HR+/HER2- metastatic breast cancer in the phase III TROPiCS-02 trial., PMID:40132065

Toxicities Associated with Sacituzumab Govitecan: Data from Clinical Trials and a Real-World Pharmacovigilance Database., PMID:40131630

Diagnosis, Prognosis, and Treatment of Triple-Negative Breast Cancer: A Review., PMID:40124876

European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2025 Guidelines., PMID:40118736

Antibody-drug conjugates in breast cancer: current evidence and future directions., PMID:40114224

Antibody-drug conjugates in rare genitourinary tumors: review and perspectives., PMID:40110990

Cost-effectiveness of sacituzumab govitecan for hormone receptor-positive human epidermal growth factor receptor 2-negative metastatic breast cancer based on the EVER-132-002 trial in China., PMID:40108623

Datasheet

Document Download

Sacituzumab govitecan (ADC).pdf

 

$ 2540
Product specifications
1 mg 2540 5 mg 6360

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Sacituzumab govitecan (ADC) [DHC43398]
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