Catalog No.
PHF56301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human GRB2 (Met1-Val217).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Protein Ash,GRB2,Growth factor receptor-bound protein 2,SH2/SH3 adapter GRB2,ASH,Adapter protein GRB2
Purification
Purified by antigen affinity column.
Accession
P62993
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Molecular classification of medulloblastoma using immunohistochemistry: A single centre study., PMID:40056547
Regulation of BCR-dependent germinal center B-cell formation by HGAL and insight into its emerging myeloid ortholog, C1ORF150., PMID:39474423
Pharmacogenomics of clinical response to Natalizumab in multiple sclerosis: a genome-wide multi-centric association study., PMID:39264442
Screening of protein-based inhibitors for the intracellular domain of epidermal growth factor receptor by directed evolution using the yeast Gγ recruitment system., PMID:39122620
Characterization of latently infected EBV+ antibody-secreting B cells isolated from ovarian tumors and malignant ascites., PMID:39086481
Leaves and pseudostems extract of Curcuma longa attenuates immunoglobulin E/bovine serum albumin-stimulated bone marrow-derived cultured mast cell activation and passive cutaneous anaphylaxis in BALB/c mice., PMID:38042384
[Cultured Cells in the Aging Research, Exhibiting Cell Surface Component Functions, Intracellular Signaling, a Novel Adaptor Molecule, Aging Phenotype Expression and Various Aspects of the Cellular Physiology]., PMID:37661439
A novel bivalent anti-c-MET/PD-1 bispecific antibody exhibits potent cytotoxicity against c-MET/PD-L1-positive colorectal cancer., PMID:37646958
Identification of a novel amphioxus leucine-rich repeat receptor involved in phagocytosis reveals a role for Slit2-N-type LRR in bacterial elimination., PMID:37044216
Clinicomorphological and molecular analysis of medulloblastoma and association with survival: A single tertiary care center experience., PMID:38384024
Anti-c-MET Fab-Grb2-Gab1 Fusion Protein-Mediated Interference of c-MET Signaling Pathway Induces Methuosis in Tumor Cells., PMID:36233320
A preliminary, prospective study of peripheral neuropathy and cognitive function in patients with breast cancer during taxane therapy., PMID:36206298
Specific phosphorylation of microtubule-associated protein 2c by extracellular signal-regulated kinase reduces interactions at its Pro-rich regions., PMID:35987383
A common IL-4 receptor variant promotes asthma severity via a Treg cell GRB2-IL-6-Notch4 circuit., PMID:35841382
Protein-PAINT: Superresolution microscopy with signaling proteins., PMID:35104163
IL-27 signaling negatively regulates FcɛRI-mediated mast cell activation and allergic response., PMID:35075687
Genome-wide association studies for immunoglobulin concentrations in colostrum and serum in Chinese Holstein., PMID:35012443
Lactic Acid Bacteria Fermented Cordyceps militaris (GRC-SC11) Suppresses IgE Mediated Mast Cell Activation and Type I Hypersensitive Allergic Murine Model., PMID:34836105
Genome-Wide Association Study of Growth Performance and Immune Response to Newcastle Disease Virus of Indigenous Chicken in Rwanda., PMID:34745207
FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2., PMID:34697226
Subcellular Dynamic Immunopatterning of Cytosolic Protein Complexes on Microstructured Polymer Substrates., PMID:34652152
Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling., PMID:34526379
Effect of the glycine-rich domain in GAREM2 on its unique subcellular localization upon EGF stimulation., PMID:33931009
Description of the genetic variants identified in a cohort of patients diagnosed with localized anal squamous cell carcinoma and treated with panitumumab., PMID:33795829
T-cell immunoglobulin and ITIM domain, as a potential immune checkpoint target for immunotherapy of colorectal cancer., PMID:33686787
Medulloblastoma: clinicopathological parameters, risk stratification, and survival analysis of immunohistochemically validated molecular subgroups., PMID:33555447
Roles of Pyk2 in signal transduction after gonadotropin-releasing hormone receptor stimulation., PMID:32984962
[SLAM family proteins as therapeutic targets in multiple myeloma]., PMID:32759570
Therapeutic efficacy of liposomal Grb2 antisense oligodeoxynucleotide (L-Grb2) in preclinical models of ovarian and uterine cancer., PMID:32754300
CB1 Cannabinoid Receptors Stimulate Gβγ-GRK2-Mediated FAK Phosphorylation at Tyrosine 925 to Regulate ERK Activation Involving Neuronal Focal Adhesions., PMID:32655375
5-Bromo-3,4-dihydroxybenzaldehyde from Polysiphonia morrowii attenuate IgE/BSA-stimulated mast cell activation and passive cutaneous anaphylaxis in mice., PMID:32531348
Fully Automated Protein Proximity Assay in Formalin-Fixed, Paraffin-Embedded Tissue Using Caged Haptens., PMID:32395983
Preparation of a Novel One-Armed Anti-c-Met Antibody with Antitumor Activity Against Hepatocellular Carcinoma., PMID:31849449
Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling., PMID:31362927
High-Throughput Phosphotyrosine Protein Complexes Screening by Photoaffinity-Engineered Protein Scaffold-Based Forward-Phase Protein Array., PMID:31282657
NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity., PMID:31235500
The B cell novel protein 1 (BCNP1) regulates BCR signaling and B cell apoptosis., PMID:30888050
Synergistic effects of SHP2 and PI3K pathway inhibitors in GAB2-overexpressing ovarian cancer., PMID:30755818
Epstein-Barr virus microRNAs regulate B cell receptor signal transduction and lytic reactivation., PMID:30615681
An autoimmune disease variant of IgG1 modulates B cell activation and differentiation., PMID:30287618
Profiling the origin, dynamics, and function of traction force in B cell activation., PMID:30087179
Valproic Acid Decreases the Nuclear Localization of MDT-28, the Nematode Orthologue of MED28., PMID:29871732
The role of the ShcD and RET interaction in neuroblastoma survival and migration., PMID:29556564
Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells., PMID:29523808
Transient Acceleration of Epidermal Growth Factor Receptor Dynamics Produces Higher-Order Signaling Clusters., PMID:29505756
BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines., PMID:29326440
Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responses., PMID:28842433
In-Solution SH2 Domain Binding Assay Based on Proximity Ligation., PMID:28092041
Themis2 lowers the threshold for B cell activation during positive selection., PMID:27992403
Inhibition of integrin β3, a binding partner of kallistatin, leads to reduced viability, invasion and proliferation in NCI-H446 cells., PMID:27980455
For research use only. Not for human or drug use.
