Catalog No.
PVV30001
Species reactivity
Human metapneumovirus (strain CAN97-83) (HMPV)
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant HMPV N/Nucleoprotein (Met1-Glu394).
Applications
ELISA, IHC, WB
Recommended Dilution
| Application |
Dilution |
| ELISA |
1:4000-1:8000, IHC: 1:50-1:200, WB: 1:500-1:4000 |
Target
Nucleoprotein, Protein N, Nucleocapsid protein, N
Concentration
0.84 mg/ml
Purification
Purified by antigen affinity column.
Accession
Q6WBA1
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note
For research use only.
Viral and host factors determine innate immune responses in airway epithelial cells from children with wheeze and atopy., PMID:24811725
A broadly neutralizing human monoclonal antibody exhibits in vivo efficacy against both human metapneumovirus and respiratory syncytial virus., PMID:24864121
Rational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral mRNA cap methyltransferase., PMID:25056882
Isolation and characterization of a subtype C avian metapneumovirus circulating in Muscovy ducks in China., PMID:25060776
Serologic cross-reactions between nucleocapsid proteins of human respiratory syncytial virus and human metapneumovirus., PMID:25740767
An outbreak of human metapneumovirus in a rehabilitation center for alcoholics in Tampere, Finland., PMID:25761612
Zinc binding activity of human metapneumovirus M2-1 protein is indispensable for viral replication and pathogenesis in vivo., PMID:25855728
New Approaches for Immunization and Therapy against Human Metapneumovirus., PMID:26063237
Lung CD8+ T Cell Impairment Occurs during Human Metapneumovirus Infection despite Virus-Like Particle Induction of Functional CD8+ T Cells., PMID:26063431
[Prevalence and seasonal distribution of respiratory viruses in patients with acute respiratory tract infections, 2002-2014]., PMID:26167819
Sendai virus as a backbone for vaccines against RSV and other human paramyxoviruses., PMID:26648515
Immunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates., PMID:26772634
Novel Respiratory Syncytial Virus-Like Particle Vaccine Composed of the Postfusion and Prefusion Conformations of the F Glycoprotein., PMID:27030590
Novel HLA-A2-restricted human metapneumovirus epitopes reduce viral titers in mice and are recognized by human T cells., PMID:27105560
A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV., PMID:27224013
Phosphorylation of Human Metapneumovirus M2-1 Protein Upregulates Viral Replication and Pathogenesis., PMID:27252537
Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation., PMID:27611367
A Sendai virus recombinant vaccine expressing a gene for truncated human metapneumovirus (hMPV) fusion protein protects cotton rats from hMPV challenge., PMID:28605636
Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein., PMID:29142300
Chimeric Pneumoviridae fusion proteins as immunogens to induce cross-neutralizing antibody responses., PMID:29217660
Immunization with a Mixture of Nucleoprotein from Human Metapneumovirus and AbISCO-100 Adjuvant Reduces Viral Infection in Mice Model., PMID:29373084
Development and optimization of a direct plaque assay for trypsin-dependent human metapneumovirus strains., PMID:29807042
Antigenic and sequence variability of the human respiratory syncytial virus F glycoprotein compared to related viruses in a comprehensive dataset., PMID:30292456
Recombinant BCG Vaccines Reduce Pneumovirus-Caused Airway Pathology by Inducing Protective Humoral Immunity., PMID:30581437
A Potent Neutralizing Site III-Specific Human Antibody Neutralizes Human Metapneumovirus In Vivo., PMID:31292250
Antibody Epitopes of Pneumovirus Fusion Proteins., PMID:31849961
Altered Expression of the Epithelial Mucin MUC1 Accompanies Endoscopic Recurrence of Postoperative Crohn's Disease., PMID:32195770
Evaluation of Six Commercial Mid- to High-Volume Antibody and Six Point-of-Care Lateral Flow Assays for Detection of SARS-CoV-2 Antibodies., PMID:32665420
Respiratory Syncytial Virus and Human Metapneumovirus Infections in Three-Dimensional Human Airway Tissues Expose an Interesting Dichotomy in Viral Replication, Spread, and Inhibition by Neutralizing Antibodies., PMID:32759319
Antibody recognition of the Pneumovirus fusion protein trimer interface., PMID:33035266
Virus vaccines: proteins prefer prolines., PMID:33705704
Sendai Virus-Vectored Vaccines That Express Envelope Glycoproteins of Respiratory Viruses., PMID:34072332
Structure, Immunogenicity, and Conformation-Dependent Receptor Binding of the Postfusion Human Metapneumovirus F Protein., PMID:34160259
Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses., PMID:34551978
Profiling of hMPV F-specific antibodies isolated from human memory B cells., PMID:35538099
Structural basis for ultrapotent antibody-mediated neutralization of human metapneumovirus., PMID:35696580
Elicitation of pneumovirus-specific B cell responses by a prefusion-stabilized respiratory syncytial virus F subunit vaccine., PMID:35731888
Safety and Immunogenicity of an mRNA-Based Human Metapneumovirus and Parainfluenza Virus Type 3 Combined Vaccine in Healthy Adults., PMID:35794943
Potently neutralizing and protective anti-human metapneumovirus antibodies target diverse sites on the fusion glycoprotein., PMID:35944529
Role of human metapneumovirus glycoprotein G in modulation of immune responses., PMID:35958551
A Pan-Pneumovirus vaccine based on immunodominant epitopes of the fusion protein., PMID:36003370
Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirus., PMID:36130517
Cross-protective antibodies against common endemic respiratory viruses., PMID:36781872
Human Metapneumovirus (hMPV) Infection and MPV467 Treatment in Immunocompromised Cotton Rats Sigmodon hispidus., PMID:36851691
Structural basis for respiratory syncytial virus and human metapneumovirus neutralization., PMID:37544710
Structure-based design of a single-chain triple-disulfide-stabilized fusion-glycoprotein trimer that elicits high-titer neutralizing responses against human metapneumovirus., PMID:37738240
Safety and Immunogenicity of an mRNA-Based hMPV/PIV3 Combination Vaccine in Seropositive Children., PMID:38738290
Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus., PMID:39550381
A Randomized Phase 1 Clinical Trial of a Respiratory Syncytial Virus and Human Metapneumovirus Combination Protein-Based Virus-like Particle Vaccine in Adults 60-75 Years of Age., PMID:40201719
Development of Standard and Rapid Antigen Detection Assays for Human Metapneumovirus., PMID:40297986
For research use only. Not for human or drug use.
