Catalog No.
PVV30001
Species reactivity
Human metapneumovirus (strain CAN97-83) (HMPV)
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant HMPV N/Nucleoprotein (Met1-Glu394).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:200, WB: 1:500-1:4000
Target
Nucleoprotein, Protein N, Nucleocapsid protein, N
Concentration
0.98 mg/ml
Purification
Purified by antigen affinity column.
Accession
Q6WBA1
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Development of Standard and Rapid Antigen Detection Assays for Human Metapneumovirus., PMID:40297986
A Randomized Phase 1 Clinical Trial of a Respiratory Syncytial Virus and Human Metapneumovirus Combination Protein-Based Virus-like Particle Vaccine in Adults 60-75 Years of Age., PMID:40201719
Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus., PMID:39550381
Safety and Immunogenicity of an mRNA-Based hMPV/PIV3 Combination Vaccine in Seropositive Children., PMID:38738290
Structure-based design of a single-chain triple-disulfide-stabilized fusion-glycoprotein trimer that elicits high-titer neutralizing responses against human metapneumovirus., PMID:37738240
Structural basis for respiratory syncytial virus and human metapneumovirus neutralization., PMID:37544710
Human Metapneumovirus (hMPV) Infection and MPV467 Treatment in Immunocompromised Cotton Rats Sigmodon hispidus., PMID:36851691
Cross-protective antibodies against common endemic respiratory viruses., PMID:36781872
Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirus., PMID:36130517
A Pan-Pneumovirus vaccine based on immunodominant epitopes of the fusion protein., PMID:36003370
Role of human metapneumovirus glycoprotein G in modulation of immune responses., PMID:35958551
Potently neutralizing and protective anti-human metapneumovirus antibodies target diverse sites on the fusion glycoprotein., PMID:35944529
Safety and Immunogenicity of an mRNA-Based Human Metapneumovirus and Parainfluenza Virus Type 3 Combined Vaccine in Healthy Adults., PMID:35794943
Elicitation of pneumovirus-specific B cell responses by a prefusion-stabilized respiratory syncytial virus F subunit vaccine., PMID:35731888
Structural basis for ultrapotent antibody-mediated neutralization of human metapneumovirus., PMID:35696580
Profiling of hMPV F-specific antibodies isolated from human memory B cells., PMID:35538099
Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses., PMID:34551978
Structure, Immunogenicity, and Conformation-Dependent Receptor Binding of the Postfusion Human Metapneumovirus F Protein., PMID:34160259
Sendai Virus-Vectored Vaccines That Express Envelope Glycoproteins of Respiratory Viruses., PMID:34072332
Virus vaccines: proteins prefer prolines., PMID:33705704
Antibody recognition of the Pneumovirus fusion protein trimer interface., PMID:33035266
Respiratory Syncytial Virus and Human Metapneumovirus Infections in Three-Dimensional Human Airway Tissues Expose an Interesting Dichotomy in Viral Replication, Spread, and Inhibition by Neutralizing Antibodies., PMID:32759319
Evaluation of Six Commercial Mid- to High-Volume Antibody and Six Point-of-Care Lateral Flow Assays for Detection of SARS-CoV-2 Antibodies., PMID:32665420
Altered Expression of the Epithelial Mucin MUC1 Accompanies Endoscopic Recurrence of Postoperative Crohn's Disease., PMID:32195770
Antibody Epitopes of Pneumovirus Fusion Proteins., PMID:31849961
A Potent Neutralizing Site III-Specific Human Antibody Neutralizes Human Metapneumovirus In Vivo., PMID:31292250
Recombinant BCG Vaccines Reduce Pneumovirus-Caused Airway Pathology by Inducing Protective Humoral Immunity., PMID:30581437
Antigenic and sequence variability of the human respiratory syncytial virus F glycoprotein compared to related viruses in a comprehensive dataset., PMID:30292456
Development and optimization of a direct plaque assay for trypsin-dependent human metapneumovirus strains., PMID:29807042
Immunization with a Mixture of Nucleoprotein from Human Metapneumovirus and AbISCO-100 Adjuvant Reduces Viral Infection in Mice Model., PMID:29373084
Chimeric Pneumoviridae fusion proteins as immunogens to induce cross-neutralizing antibody responses., PMID:29217660
Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein., PMID:29142300
A Sendai virus recombinant vaccine expressing a gene for truncated human metapneumovirus (hMPV) fusion protein protects cotton rats from hMPV challenge., PMID:28605636
Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation., PMID:27611367
Phosphorylation of Human Metapneumovirus M2-1 Protein Upregulates Viral Replication and Pathogenesis., PMID:27252537
A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV., PMID:27224013
Novel HLA-A2-restricted human metapneumovirus epitopes reduce viral titers in mice and are recognized by human T cells., PMID:27105560
Novel Respiratory Syncytial Virus-Like Particle Vaccine Composed of the Postfusion and Prefusion Conformations of the F Glycoprotein., PMID:27030590
Immunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates., PMID:26772634
Sendai virus as a backbone for vaccines against RSV and other human paramyxoviruses., PMID:26648515
[Prevalence and seasonal distribution of respiratory viruses in patients with acute respiratory tract infections, 2002-2014]., PMID:26167819
Lung CD8+ T Cell Impairment Occurs during Human Metapneumovirus Infection despite Virus-Like Particle Induction of Functional CD8+ T Cells., PMID:26063431
New Approaches for Immunization and Therapy against Human Metapneumovirus., PMID:26063237
Zinc binding activity of human metapneumovirus M2-1 protein is indispensable for viral replication and pathogenesis in vivo., PMID:25855728
An outbreak of human metapneumovirus in a rehabilitation center for alcoholics in Tampere, Finland., PMID:25761612
Serologic cross-reactions between nucleocapsid proteins of human respiratory syncytial virus and human metapneumovirus., PMID:25740767
Isolation and characterization of a subtype C avian metapneumovirus circulating in Muscovy ducks in China., PMID:25060776
Rational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral mRNA cap methyltransferase., PMID:25056882
A broadly neutralizing human monoclonal antibody exhibits in vivo efficacy against both human metapneumovirus and respiratory syncytial virus., PMID:24864121
Viral and host factors determine innate immune responses in airway epithelial cells from children with wheeze and atopy., PMID:24811725
For research use only. Not for human or drug use.
