Catalog No.
DHM00401
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1
Clonality
Monoclonal
Target
MHC class I antigen E, HLA class I histocompatibility antigen, alpha chain E, HLA-E, HLA-6.2, sHLA-E, HLAE
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P13747
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
ABX-0020
Expanded adaptive NKG2C+ NK cells exhibit potent ADCC and functional responses against HBV-infected hepatoma cell lines., PMID:40501566
A novel NKG2A alpaca nanobody targeting immune checkpoint blockade for the treatment of malignant melanoma., PMID:40370819
From genetic variants to therapeutic targets: insights into understanding rheumatoid arthritis., PMID:40236704
Major Human Leukocyte Antigen Expression in Respiratory Papillomatosis Clinical Specimens., PMID:40078078
Memory-like NK cell differentiation, inhibitory NKG2A blockade, and improved recognition via antibody or CAR engineering combine to enhance NK cell attack against multiple myeloma., PMID:40073259
Association between human leukocyte antigen E expression and outcomes in solid tumors: a systematic review and meta-analysis., PMID:40066089
CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors., PMID:39958331
Neutralizing IL-15 Inhibits Tissue-Damaging Immune Response in Ex Vivo Cultured Untreated Celiac Intestinal Mucosa., PMID:39937025
Nationwide multi-centric prospective study for the identification of biomarkers to predict the treatment responses of nivolumab through comprehensive analyses of pretreatment plasma exosome mRNAs from head and neck cancer patients (BIONEXT study)., PMID:39867897
Elephant in the room: natural killer cells don't forget HIV either., PMID:39773904
HLA-E: Immune Receptor Functional Mechanisms Revealed by Structural Studies., PMID:39753525
Entry into the lytic cycle exposes EBV-infected cells to NK cell killing via upregulation of the MICB ligand for NKG2D and activation of the CD56bright and NKG2A+KIR+CD56dim subsets., PMID:39676862
Generation, Characterization, and Preclinical Studies of a Novel NKG2A-Targeted Antibody BRY805 for Cancer Immunotherapy., PMID:39584993
Unlocking the therapeutic potential of the NKG2A-HLA-E immune checkpoint pathway in T cells and NK cells for cancer immunotherapy., PMID:39486805
High-dimensional analysis of NK cells in kidney transplantation uncovers subsets associated with antibody-independent graft dysfunction., PMID:39388279
A role of gut microbiota metabolites in HLA-E and NKG2 blockage immunotherapy against tumors: new insights for clinical application., PMID:39229258
Correct stimulation of CD28H arms NK cells against tumor cells., PMID:39101623
A high affinity monoclonal antibody against HLA-E-VL9 enhances natural killer cell anti-tumor killing., PMID:39026709
IFNγ mediates the resistance of tumor cells to distinct NK cell subsets., PMID:38955423
NKG2A genetic deletion promotes human primary NK cell anti-tumor responses better than an anti-NKG2A monoclonal antibody., PMID:38943249
A monoclonal antibody that recognizes a unique 13-residue epitope in the cytoplasmic tail of HLA-E., PMID:38901180
Novel Targets for the Development of Tuberculosis Vaccine., PMID:38859789
The antibodies 3D12 and 4D12 recognise distinct epitopes and conformations of HLA-E., PMID:38571959
Diversity in the HLA-I Recognition of HLA-F Monoclonal Antibodies: HLA-F or HLA-Ib Monospecific, HLA-E or HLA-G Bispecific Antibodies with or without HLA-Ia Reactivity., PMID:38390869
Deciphering the immune landscape of head and neck squamous cell carcinoma: A single-cell transcriptomic analysis of regulatory T cell responses to PD-1 blockade therapy., PMID:38096229
Ineffective control of Epstein-Barr-virus-induced autoimmunity increases the risk for multiple sclerosis., PMID:38091993
Intratumoral co-injection of NK cells and NKG2A-neutralizing monoclonal antibodies., PMID:37782273
Understanding the heterogeneity of alloreactive natural killer cell function in kidney transplantation., PMID:37732256
Antibody-mediated rejection in xenotransplantation: Can it be prevented or reversed?, PMID:37548030
Co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells attenuates human NK cell-mediated degranulation., PMID:37529053
XPO1 inhibition sensitises CLL cells to NK cell mediated cytotoxicity and overcomes HLA-E expression., PMID:37528310
Defining the role of natural killer cells in COVID-19., PMID:37460639
Histocompatibility assessment in hematopoietic stem cell transplantation: recommendations from the Italian Society for Immunogenetics and Transplantation Biology (Associazione Italiana di Immunogenetica e Biologia dei Trapianti - AIBT)., PMID:37458719
Inhibitory NKG2A+ and absent activating NKG2C+ NK cell responses are associated with the development of EBV+ lymphomas., PMID:37426645
HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation., PMID:37390223
Association between human genetic variants affecting the host NK cell response and the development of herpes simplex virus type 1 encephalitis., PMID:37212301
Intracellular trafficking of HLA-E and its regulation., PMID:37140910
Antibodies for β2-Microglobulin and the Heavy Chains of HLA-E, HLA-F, and HLA-G Reflect the HLA-Variants on Activated Immune Cells and Phases of Disease Progression in Rheumatoid Arthritis Patients under Treatment., PMID:37092447
Targets of Immune Escape Mechanisms in Cancer: Basis for Development and Evolution of Cancer Immune Checkpoint Inhibitors., PMID:36829496
HLA-E*01:01 + HLA-E*01:01 genotype confers less susceptibility to COVID-19, while HLA-E*01:03 + HLA-E*01:03 genotype is associated with more severe disease., PMID:36822912
Histological Characterization of Class I HLA Molecules in Whole Umbilical Cord Tissue Towards an Inexhaustible Graft Alternative for Reconstructive Surgery., PMID:36671682
Disruption of the NKG2A:HLA-E Immune Checkpoint Axis to Enhance NK Cell Activation against Cancer., PMID:36560403
Monalizumab efficacy correlates with HLA-E surface expression and NK cell activity in head and neck squamous carcinoma cell lines., PMID:36547689
Inhibitory receptors for HLA class I as immune checkpoints for natural killer cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy., PMID:36261539
Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer., PMID:36149610
Single-cell RNA Sequencing Analysis Reveals New Immune Disorder Complexities in Hypersplenism., PMID:35865544
Sib-pair subgroup familial type 1 diabetes mellitus in children in the state of Qatar., PMID:35802651
Diversity of NKG2C genotypes in a European population: Conserved and recombinant haplotypes in the coding, promoter, and 3'-untranslated regions., PMID:35802353
Current HLA testing recommendations to support HCT., PMID:35798627
NKG2A-checkpoint inhibition and its blockade critically depends on peptides presented by its ligand HLA-E., PMID:35596615
For research use only. Not for human or drug use.
