Catalog No.
DHK16102
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1
Clonality
Monoclonal
Target
SAF2, Sialoadhesin family member 2, SAF-2, Siglec-8, SIGLEC8, Sialic acid-binding Ig-like lectin 8
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9NYZ4
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
1H10
Vectorized Human Antibody-Mediated Anti-Eosinophil Gene Therapy., PMID:39725494
Pharmacologic Treatment of Eosinophilic Esophagitis: Efficacious, Likely Efficacious, and Failed Drugs., PMID:39474328
Optimizing Siglec-8-Directed Immunotherapy for Eosinophilic and Mast Cell Disorders., PMID:39456570
Increased autoreactivity and maturity of EBI2+ antibody-secreting cells from nasal polyps., PMID:39253973
Flow cytometric immunophenotypic differentiation patterns of bone marrow eosinophilopoiesis., PMID:38666394
Mast Cell-Targeting Therapies in Mast Cell Activation Syndromes., PMID:38217824
Regulation of mast cells by overlapping but distinct protein interactions of Siglec-6 and Siglec-8., PMID:38186079
Interactions between Siglec-8 and endogenous sialylated cis ligands restrain cell death induction in human eosinophils and mast cells., PMID:37928558
Mast cell silencing: A novel therapeutic approach for urticaria and other mast cell-mediated diseases., PMID:37605867
Safety and efficacy of lirentelimab in patients with refractory indolent systemic mastocytosis: a first-in-human clinical trial., PMID:37290787
Integrated Bioinformatics Analysis for the Identification of Key lncRNAs, mRNAs, and Potential Drugs in Clear Cell Renal Cell Carcinomas., PMID:37275334
Biomarkers for predicting type 2-high and uncontrolled asthma in real-world practice., PMID:37209833
Emerging therapies for eosinophilic esophagitis., PMID:36840634
Jak out of the box: Targeting Bruton's tyrosine kinase, sialic acid-binding immunoglobulin-like lectin-8, and Janus kinase 1 in food allergy., PMID:36738782
Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody., PMID:36711084
Human Lung Mast Cells: Therapeutic Implications in Asthma., PMID:36430941
Novel peanut-specific human IgE monoclonal antibodies enable screens for inhibitors of the effector phase in food allergy., PMID:36248809
Pharmacological Induction of Granulocyte Cell Death as Therapeutic Strategy., PMID:36028226
Treatment Trends for Eosinophilic Esophagitis and the Other Eosinophilic Gastrointestinal Diseases: Systematic Review of Clinical Trials., PMID:35654734
Drug treatment strategies for eosinophilic esophagitis in adults., PMID:35379069
Anti-phospholipid antibodies are elevated and functionally active in chronic rhinosinusitis with nasal polyps., PMID:35253284
The Inhibitory Receptor Siglec-8 Interacts With FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation., PMID:35154156
Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro., PMID:34721399
Understanding human mast cells: lesson from therapies for allergic and non-allergic diseases., PMID:34611316
Determination of Biopsy Yield That Optimally Detects Eosinophilic Gastritis and/or Duodenitis in a Randomized Trial of Lirentelimab., PMID:34089846
Nanoparticles Displaying Allergen and Siglec-8 Ligands Suppress IgE-FcεRI-Mediated Anaphylaxis and Desensitize Mast Cells to Subsequent Antigen Challenge., PMID:33911007
Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody., PMID:33777047
Discovery, Function, and Therapeutic Targeting of Siglec-8., PMID:33374255
Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration., PMID:33289969
Anti-Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis., PMID:33085861
A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation., PMID:32814824
A Potent Mimetic of the Siglec-8 Ligand 6'-Sulfo-Sialyl Lewisx., PMID:32744401
Divergent Siglec-F(eights) of mouse and human eosinophil death., PMID:32557797
An anti-siglec-8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells., PMID:32542913
Targeted Therapies for Eosinophilic Gastrointestinal Disorders., PMID:32472465
Frontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls., PMID:32134149
Clinical factors associated with acute exacerbations of chronic rhinosinusitis., PMID:32004523
Future therapies for eosinophilic gastrointestinal disorders., PMID:31778820
Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis., PMID:31465299
New treatments for chronic urticaria., PMID:31446134
AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice., PMID:31401630
Transcriptomics of atopy and atopic asthma in white blood cells from children and adolescents., PMID:30923181
Eosinophils in anti-neutrophil cytoplasmic antibody associated vasculitis., PMID:30886997
Therapeutic strategies for eosinophilic dermatoses., PMID:30743138
Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice., PMID:30577572
Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies., PMID:30543818
Immunomodulators in chronic rhinosinusitis., PMID:30506050
New biologics in the treatment of urticaria., PMID:30015639
No difference in human mast cells derived from peanut allergic versus non-allergic subjects., PMID:29992767
Sialylation pattern in lung epithelial cell line and Siglecs expression in monocytic THP-1 cells as cellular indicators of cigarette smoke - induced pathology in vitro., PMID:29781747
For research use only. Not for human or drug use.
