Catalog No.
DHH28902
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1
Clonality
Monoclonal
Target
SCA-2, TSA-1, 9804, Retinoic acid-induced gene E protein, TSA1, Lymphocyte antigen 6E, Ly-6E, Stem cell antigen 2, Thymic shared antigen 1, SCA2, RIGE, LY6E, RIG-E
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q16553
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Hu9B12v12
Development of T-cell engagers selective for cells co-expressing two antigens., PMID:36206404
Species-specific transcriptomic changes upon respiratory syncytial virus infection in cotton rats., PMID:36195733
The structural and functional divergence of a neglected three-finger toxin subfamily in lethal elapids., PMID:35830808
Association between interferon-I producing plasmacytoid dendritic cells and thrombotic antiphospholipid syndrome., PMID:35612283
Lessons in self-defence: inhibition of virus entry by intrinsic immunity., PMID:34646033
The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation., PMID:34606831
Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response., PMID:33382956
Anti-Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals., PMID:33020064
A Phase I Study of DLYE5953A, an Anti-LY6E Antibody Covalently Linked to Monomethyl Auristatin E, in Patients with Refractory Solid Tumors., PMID:32694157
Circulating plasmablasts contribute to antiphospholipid antibody production, associated with type I interferon upregulation., PMID:30864219
CD4-Dependent Modulation of HIV-1 Entry by LY6E., PMID:30674630
Epstein-Barr virus infection and type I interferon signature in patients with systemic lupus erythematosus., PMID:29338588
Lack of Interferon and Proinflammatory Cyto/chemokines in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus., PMID:26568589
An Antibody-Drug Conjugate Directed against Lymphocyte Antigen 6 Complex, Locus E (LY6E) Provides Robust Tumor Killing in a Wide Range of Solid Tumor Malignancies., PMID:25862760
Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus., PMID:25344775
The interferon type I signature towards prediction of non-response to rituximab in rheumatoid arthritis patients., PMID:22540992
Search for specific biomarkers of IFNβ bioactivity in patients with multiple sclerosis., PMID:21886806
Lack of association between the interferon-alpha signature and longitudinal changes in disease activity in systemic lupus erythematosus., PMID:18772188
Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus., PMID:16947629
Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy., PMID:16864781
Ly-6 superfamily members Ly-6A/E, Ly-6C, and Ly-6I recognize two potential ligands expressed by B lymphocytes., PMID:12391229
Testis-specific antigen (TSA-1) is expressed in murine sperm and its antibodies inhibit fertilization., PMID:11883748
Novel human testis-specific cDNA: molecular cloning, expression and immunobiological effects of the recombinant protein., PMID:11550262
Differential expression of genes by tumor cells of a low or a high malignancy phenotype: the case of murine and human Ly-6 proteins., PMID:10762016
TNFalpha and anti-Fas antibodies regulate Ly-6E.1 expression by tumor cells: a possible link between angiogenesis and Ly-6E.1., PMID:9052880
The Ly-6E.1 (Sca-1) gene requires a 3' chromatin-dependent region for high-level gamma-interferon-induced hematopoietic cell expression., PMID:8639891
Multiple glycosylphosphatidylinositol-anchored Ly-6 molecules and transmembrane Ly-6E mediate inhibition of IL-2 production., PMID:8051400
Cloning of the complete Ly-6E.1 gene and identification of DNase I hypersensitive sites corresponding to expression in hematopoietic cells., PMID:8219196
Enrichment and functional characterization of Sca-1+WGA+, Lin-WGA+, Lin-Sca-1+, and Lin-Sca-1+WGA+ bone marrow cells from mice with an Ly-6a haplotype., PMID:8219220
Role of Ly-6A/E and T cell receptor-zeta for IL-2 production. Phosphatidylinositol-anchored Ly-6A/E antagonizes T cell receptor-mediated IL-2 production by a zeta-independent pathway., PMID:1387661
The glycosyl phosphatidylinositol anchor is critical for Ly-6A/E-mediated T cell activation., PMID:1825084
Ly-6 A/E antigen of murine T cells is associated with a distinct pathway of activation. Requirements for interferon and exogenous interleukin 2., PMID:2454826
The augmentation of surface Ly-6A/E molecules in activated T cells is mediated by endogenous interferon-gamma., PMID:3121727
Selective up-regulation by interferon-gamma of surface molecules of the Ly-6 complex in resting T cells: the Ly-6A/E and TAP antigens are preferentially enhanced., PMID:3040423
Role of Ly-6 in lymphocyte activation. I. Characterization of a monoclonal antibody to a nonpolymorphic Ly-6 specificity., PMID:2430016
Ly-6A.2 and Ly-6E.1 molecules are antithetical and identical to MALA-1., PMID:3957415
Biochemical characterization of the murine activated lymphocyte alloantigen Ly-6E.1 controlled by the Ly-6 locus., PMID:3941270
For research use only. Not for human or drug use.
