Catalog No.
DHJ27903
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1
Clonality
Monoclonal
Target
MOX2R, Cell surface glycoprotein OX2 receptor 1, OX2R, Cell surface glycoprotein CD200 receptor 1, CD200R, CD200 cell surface glycoprotein receptor, CRTR2, CD200R1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q8TD46
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
huDX182
Ucenprubart is an agonistic antibody to CD200R with the potential to treat inflammatory skin disease: preclinical development and a phase 1 clinical study., PMID:40312358
Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway., PMID:40049088
First-in-Human Study of 23ME-00610, an Antagonistic Antibody for Genetically Validated CD200R1 Immune Checkpoint, in Participants with Advanced Solid Malignancies., PMID:39651931
CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody., PMID:39402718
Endothelial Cell-Derived Soluble CD200 Determines the Ability of Immune Cells to Cross the Blood-Brain Barrier., PMID:39273210
Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats., PMID:38237226
Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice., PMID:37902837
Different mechanisms of CD200-CD200R induce diverse outcomes in cancer treatment., PMID:37734537
23ME-00610, a genetically informed, first-in-class antibody targeting CD200R1 to enhance antitumor T cell function., PMID:37288324
Transcriptome analysis of Homo sapiens and Mus musculus reveals mechanisms of CD8+ T cell exhaustion caused by different factors., PMID:36084049
Reduced cutaneous CD200:CD200R1 signaling in psoriasis enhances neutrophil recruitment to skin., PMID:35759230
CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury., PMID:35681481
CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells., PMID:35231818
Soporific effect of modified Suanzaoren Decoction on mice models of insomnia by regulating Orexin-A and HPA axis homeostasis., PMID:34509822
CD200R1 and CD200R1L expression is regulated during B cell development in swine and modulates the Ig production in response to the TLR7 ligand imiquimoid., PMID:33961666
CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils., PMID:33884657
The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease., PMID:33823877
Activation of pro- and anti-inflammatory responses in lung tissue injury during the acute phase of PRRSV-1 infection with the virulent strain Lena., PMID:32605751
Increased CD200 levels in peripheral blood mononuclear cells of patients with primary Sjögren's syndrome., PMID:32180363
TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in mice., PMID:31654653
Bone marrow-mesenchymal stem cells modulate microglial activation in the peri-infarct area in rats during the acute phase of stroke., PMID:31589902
Analysis of the expression of porcine CD200R1 and CD200R1L by using newly developed monoclonal antibodies., PMID:31233758
CD200Fc Improves Neurological Function by Protecting the Blood-brain Barrier after Intracerebral Hemorrhage., PMID:31208229
Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer., PMID:30179225
CD200 modulates spinal cord injury neuroinflammation and outcome through CD200R1., PMID:29870752
Anti-inflammation conferred by stimulation of CD200R1 via Dok1 pathway in rat microglia after germinal matrix hemorrhage., PMID:28792282
CD200Fc reduces LPS-induced IL-1β activation in human cervical cancer cells by modulating TLR4-NF-κB and NLRP3 inflammasome pathway., PMID:28402258
Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and βklotho agonist antibodies., PMID:28363871
Importance of CD200 expression by tumor or host cells to regulation of immunotherapy in a mouse breast cancer model., PMID:28234914
Monocytes, microglia, and CD200-CD200R1 signaling are essential in the transmission of inflammation from the periphery to the central nervous system., PMID:28164283
A comparison of serum miRNAs influencing metastatic growth of EMT6 vs 4THM tumor cells in wild-type and CD200R1KO mice., PMID:28160157
Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis., PMID:27929051
CD200Fc attenuates inflammatory responses and maintains barrier function by suppressing NF-κB pathway in cigarette smoke extract induced endothelial cells., PMID:27710895
Impact of CD200-Fc on dendritic cells in lupus-prone NZB/WF1 mice., PMID:27545083
[CD200/CD200R Expression Levels and Its Significance after Allogeneic Hematopoietic Stem Cell Transplantation]., PMID:27342516
Characterization of CD200 Ectodomain Shedding., PMID:27111430
Immune checkpoint inhibitors enhance cytotoxicity of cytokine-induced killer cells against human myeloid leukaemic blasts., PMID:26961084
CD200Fc reduces TLR4-mediated inflammatory responses in LPS-induced rat primary microglial cells via inhibition of the NF-κB pathway., PMID:26956766
Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ(9) -tetrahydrocannabinol., PMID:26799708
Evaluation of the antigenicity of hydrolyzed cow's milk protein formulas using the mouse basophil activation test., PMID:26626100
Decreased expression of CD200R3 on mouse basophils as a novel marker for IgG1-mediated anaphylaxis., PMID:26417442
The CD200 tolerance-signaling molecule and its receptor, CD200R1, are expressed in human placental villus trophoblast and in peri-implant decidua by 5 weeks' gestation., PMID:26123445
The Receptor for the CD200 Tolerance-Signaling Molecule Associated with Successful Pregnancy is Expressed by Early-Stage Breast Cancer Cells in 80% of Patients and by Term Placental Trophoblasts., PMID:26011475
Local targeting of the CD200-CD200R axis does not promote corneal graft survival., PMID:25450061
Comparison of immunity in mice cured of primary/metastatic growth of EMT6 or 4THM breast cancer by chemotherapy or immunotherapy., PMID:25409195
Aberrant CD200/CD200R1 expression and its potential role in Th17 cell differentiation, chemotaxis and osteoclastogenesis in rheumatoid arthritis., PMID:25261692
The CD200-CD200 receptor inhibitory axis controls arteriogenesis and local T lymphocyte influx., PMID:24897500
The CD200-CD200R1 inhibitory signaling pathway: immune regulation and host-pathogen interactions., PMID:24388216
Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-β abolishes increased graft survival and Treg induction induced in cromolyn-treated CD200R1KO.CD200tg mice., PMID:24142033
Dissection of agonistic and blocking effects of CD200 receptor antibodies., PMID:23691022
For research use only. Not for human or drug use.
