Catalog No.
DHD65603
Expression system
Mammalian Cells
Species reactivity
Human
Isotype
Bispecific Antibody
Clonality
Monoclonal
Target
STAR, Intestinal guanylate cyclase, GC-C, GUC2C, STA receptor, Heat-stable enterotoxin receptor, Guanylyl cyclase C, hSTAR, GUCY2C, T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T-cell surface glycoprotein CD3 epsilon chain
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P25092 & P07766
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
Bispecific
Clone ID
PF-07062119
Comprehensive evaluation of clinical phenotypes and pathogenic features in late-onset monogenic inflammatory bowel disease: a comparative study with infantile-onset cases., PMID:40474095
A proteomic atlas of glypican-3 interacting partners: Identification of alpha-fetoprotein and other extracellular proteins as potential immunotherapy targets in liver cancer., PMID:39822733
Phosphodiesterase inhibition and Gucy2C activation enhance tyrosine hydroxylase Ser40 phosphorylation and improve 6-hydroxydopamine-induced motor deficits., PMID:39456033
Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells., PMID:39366753
CD8α Structural Domains Enhance GUCY2C CAR-T Cell Efficacy., PMID:39315411
Chimeric Antigen Receptor T Cells Targeting CD19 and GCC in Metastatic Colorectal Cancer: A Nonrandomized Clinical Trial., PMID:39298141
A pilot study of childhood-onset Takayasu arteritis using whole exome sequencing suggests oligogenic inheritance involving classical complement, collagen, and autoinflammatory pathways., PMID:38869681
Gene Coexpression and miRNA Regulation: A Path to Early Intervention in Colorectal Cancer., PMID:38767504
GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults., PMID:38615030
cGMP-dependent kinase 2, Na+/H+ exchanger NHE3, and PDZ-adaptor NHERF2 co-assemble in apical membrane microdomains., PMID:38533975
Clinical course and therapeutic trial for a case of congenital secretory diarrhea due to novel GUCY2C variant., PMID:38058249
Fundamental Neurochemistry Review: The role of enteroendocrine cells in visceral pain., PMID:38037432
Enteroendocrine cell regulation of the gut-brain axis., PMID:38027512
GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults., PMID:37886524
Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3., PMID:37591971
Single-cell analysis of cellular heterogeneity and interactions in the ischemia-reperfusion injured mouse intestine., PMID:37577387
Updated Clinical Perspectives and Challenges of Chimeric Antigen Receptor-T Cell Therapy in Colorectal Cancer and Invasive Breast Cancer., PMID:37566162
Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism., PMID:37535399
Successful therapy for congenital sodium diarrhea by enteral management: A case report., PMID:37399692
Effect of guanylin peptides on pancreas steatosis and function in experimental diet-induced obesity and after bariatric surgery., PMID:37274331
Guanylyl cyclase C ameliorates visceral pain: an unsuspected link., PMID:36787251
The Intestinal Tract Brush Border in Young Children Uniformly Expresses Guanylate Cyclase C., PMID:36735491
Congenital Sodium Diarrhea Caused by a Novel Spontaneous Mutation in the GUCY2C Gene., PMID:36598634
Intestinal neuropod cell GUCY2C regulates visceral pain., PMID:36548082
Guanylyl cyclase C as a diagnostic and therapeutic target in colorectal cancer., PMID:35920071
A novel peptide protects against diet-induced obesity by suppressing appetite and modulating the gut microbiota., PMID:35803703
Chimeric adenoviral (Ad5.F35) and listeria vector prime-boost immunization is safe and effective for cancer immunotherapy., PMID:35739202
Identification of Candidate Therapeutic Genes for More Precise Treatment of Esophageal Squamous Cell Carcinoma and Adenocarcinoma., PMID:35664298
T-Cell Responses to Immunodominant Listeria Epitopes Limit Vaccine-Directed Responses to the Colorectal Cancer Antigen, Guanylyl Cyclase C., PMID:35355987
Swelling-induced upregulation of miR-141-3p inhibits hepatocyte proliferation., PMID:35287291
Analyzing large scale gene expression data in colorectal cancer reveals important clues; CLCA1 and SELENBP1 downregulated in CRC not in normal and not in adenoma., PMID:35141024
High plasma and lingual uroguanylin as potential contributors to changes in food preference after sleeve gastrectomy., PMID:34990711
A β-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer., PMID:34954189
A Potential Treatment of Congenital Sodium Diarrhea in Patients With Activating GUCY2C Mutations., PMID:34797252
Phase I double-blind, placebo-controlled trial of dolcanatide (SP-333) 27 mg to explore colorectal bioactivity in healthy volunteers., PMID:34632925
Correction: Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C., PMID:34614150
Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C., PMID:34546338
Preclinical Evaluation of 89Zr-Df-IAB22M2C PET as an Imaging Biomarker for the Development of the GUCY2C-CD3 Bispecific PF-07062119 as a T Cell Engaging Therapy., PMID:34143379
Circulating PTGS2, JAG1, GUCY2C and PGF mRNA in Peripheral Blood and Serum as Potential Biomarkers for Patients with Metastatic Colon Cancer., PMID:34067294
Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential., PMID:34056991
GUCY2C as a biomarker to target precision therapies for patients with colorectal cancer., PMID:34027103
The shifting paradigm of colorectal cancer treatment: a look into emerging cancer stem cell-directed therapeutics to lead the charge toward complete remission., PMID:33977849
Accessing Targeted Therapies: A Potential Roadblock to Implementing Precision Oncology?, PMID:33970688
Novel GUCY2C variant causing familial diarrhea in a Mennonite kindred and a potential therapeutic approach., PMID:33949097
Meconium Ileus due to GUCY2C gene mutations in three unrelated South Indian families., PMID:33883099
Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies., PMID:33470843
Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors., PMID:33459147
Peripheral Guanylate Cyclase-C modulation of corticolimbic activation and corticotropin-releasing factor signaling in a rat model of stress-induced colonic hypersensitivity., PMID:33373484
Identification of molecular features correlating with tumor immunity in gastric cancer by multi-omics data analysis., PMID:33145269
An update on guanylyl cyclase C in the diagnosis, chemoprevention, and treatment of colorectal cancer., PMID:32945718
For research use only. Not for human or drug use.
