Catalog No.
PHF38701
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CDC42 (Met1-Cys188).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
CDC42,G25K GTP-binding protein,Cell division control protein 42 homolog
Purification
Purified by antigen affinity column.
Accession
P60953
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Cdc42 Activation in Anti-nephrin Antibody-Induced Nephropathy., PMID:40459930
Glomerular mesangial cells derived complement factor H regulates complement activation, influences cell proliferation, and maintains actin cytoskeleton., PMID:40157080
aPKC/Par3/Par6 polarity complexes regulate podocyte motility and crescent formation in the progression of ANCA-associated vasculitis., PMID:39700430
Beta cell-specific PAK1 enrichment ameliorates diet-induced glucose intolerance in mice by promoting insulin biogenesis and minimising beta cell apoptosis., PMID:39404845
Emu oil alleviates atopic dermatitis-like responses by inhibiting Cdc42 signaling of keratinocyte., PMID:39032473
Siglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia., PMID:38890323
NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis., PMID:38730334
Myeloid Deletion of Cdc42 Protects Liver From Hepatic Ischemia-Reperfusion Injury via Inhibiting Macrophage-Mediated Inflammation in Mice., PMID:38342302
Cdc42-driven endosomal cholesterol transport promotes collateral resistance in HER2-positive gastric cancer., PMID:38336288
A metabolic role for CD47 in pancreatic β cell insulin secretion and islet transplant outcomes., PMID:37820008
Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2-positive gastric cancer., PMID:37434399
Serum CDC42 is increased during tumor necrosis factor inhibitor treatment, and its elevation correlates with satisfactory treatment response in rheumatoid arthritis patients., PMID:37382403
The clinical phenotype with gastrostomy and abdominal wall infection in a pediatric patient with Takenouchi-Kosaki syndrome due to a heterozygous c.191A > G (p.Tyr64Cys) variant in CDC42: a case report., PMID:37347054
Analysing transcriptomic signatures and identifying potential genes for the protective effect of inactivated COVID-19 vaccines., PMID:37096063
Identification of key genes and imbalance of immune cell infiltration in immunoglobulin A associated vasculitis nephritis by integrated bioinformatic analysis., PMID:37026011
Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity., PMID:36427906
Spatial models of pattern formation during phagocytosis., PMID:36190993
Cdc42 Promotes Axonogenesis of Primary Hippocampal Neurons by Inhibiting Glycogen Synthase Kinase-3β., PMID:36137969
Annexin A2 and Kidney Diseases., PMID:36120574
Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B virus infection and replication., PMID:35660020
Cell division control 42 elevates during infliximab therapy, and its increment relates to treatment response in ulcerative colitis patients., PMID:35527674
Regulation of biomaterial implantation-induced fibrin deposition to immunological functions of dendritic cells., PMID:35252832
Interleukin-8: An evolving chemokine., PMID:35247648
Synovial fluid from end-stage osteoarthritis induces proliferation and fibrosis of articular chondrocytes via MAPK and RhoGTPase signaling., PMID:35176481
Adhesion and proliferation properties of type I collagen-derived peptide for possible use in skin tissue engineering application., PMID:34882901
CDC42EP3 is a key promoter involved in the development and progression of gastric cancer., PMID:34111280
Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling., PMID:34108958
MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis., PMID:33941653
The anti-Rac1-GTP antibody and the detection of active Rac1: a tool with a fundamental flaw., PMID:33910489
Myeloid-derived suppressor cell (MDSC) key genes analysis in rat anti-CD28-induced immune tolerance kidney transplantation., PMID:33532310
Progressive decline of T and B cell numbers and function in a patient with CDC42 deficiency., PMID:33405195
Inhibition of p70 isoforms of S6K1 induces anoikis to prevent transformed human hepatocyte growth., PMID:33189822
Prematurity negatively affects regenerative properties of human amniotic epithelial cells in the context of lung repair., PMID:33000862
Cdc42 regulates cell polarization and contractile actomyosin rings during terminal differentiation of human erythroblasts., PMID:32678227
A Review on the Function and Regulation of ARHGDIB/RhoGDI2 Expression Including the Hypothetical Role of ARHGDIB/RhoGDI2 Autoantibodies in Kidney Transplantation., PMID:32548242
Tissue stiffness contributes to YAP activation in bladder cancer patients undergoing transurethral resection., PMID:32428277
Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome., PMID:32376602
A RhoGAP venom protein from Microplitis mediator suppresses the cellular response of its host Helicoverpa armigera., PMID:32173445
miR-485-5p suppresses Schwann cell proliferation and myelination by targeting cdc42 and Rac1., PMID:31877301
Integrin crosstalk allows CD4+ T lymphocytes to continue migrating in the upstream direction after flow., PMID:31851360
Dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and survival in breast cancer: a retrospective analysis of protein and mRNA expression., PMID:31740718
CHL1 suppresses tumor growth and metastasis in nasopharyngeal carcinoma by repressing PI3K/AKT signaling pathway via interaction with Integrin β1 and Merlin., PMID:31523184
Growth Hormone Aggregates Activation of Human Dendritic Cells Is Controlled by Rac1 and PI3 Kinase Signaling Pathways., PMID:31520643
Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice., PMID:31302143
Low-dose ionizing radiation attenuates mast cell migration through suppression of monocyte chemoattractant protein-1 (MCP-1) expression by Nr4a2., PMID:31287373
Resolvin D1 promotes the targeting and clearance of necroptotic cells., PMID:31222041
Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration., PMID:31143189
Overexpression of CDC42SE1 in A431 Cells Reduced Cell Proliferation by Inhibiting the Akt Pathway., PMID:30717410
The CDC42 effector protein MRCKβ autophosphorylates on Threonine 1108., PMID:30667325
Combination therapy targeting the elevated interleukin-6 level reduces invasive migration of BRAF inhibitor-resistant melanoma cells., PMID:30582770
For research use only. Not for human or drug use.
