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Anti-PLK1 Polyclonal Antibody

Catalog #:   PHE97401 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: P53350
Overview

Catalog No.

PHE97401

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PLK1 (Val415-Ser603).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Serine/threonine-protein kinase 13,PLK-1,PLK1,PLK,STPK13,Serine/threonine-protein kinase PLK1,Polo-like kinase 1

Purification

Purified by antigen affinity column.

Accession

P53350

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with PLK1 antibody (PHE97401) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 24 kDa
    Observed MW: 24 kDa
References

4D label-free quantitative proteomic and phosphoproteomic profiling of the kidney in rat models of antimyeloperoxidase-associated vasculitis., PMID:40201969

Onvansertib in Combination With Chemotherapy and Bevacizumab in Second-Line Treatment of KRAS-Mutant Metastatic Colorectal Cancer: A Single-Arm, Phase II Trial., PMID:39475591

Supramolecular Bioconjugation Strategy for Antibody-Targeted Delivery of siRNA., PMID:39321037

PLK1-activating IFI16-STING-TBK1 pathway induces apoptosis of intestinal epithelial cells in patients with intestinal Behçet's syndrome., PMID:38676954

An Antibody-CRISPR/Cas Conjugate Platform for Target-Specific Delivery and Gene Editing in Cancer., PMID:38552157

O-GlcNAcylation stimulates the deubiquitination activity of USP16 and regulates cell cycle progression., PMID:38462164

Multidimensional screening of pancreatic cancer spheroids reveals vulnerabilities in mitotic and cell-matrix adhesion signaling that associate with metastatic progression and decreased patient survival., PMID:38382357

Targeted delivery of immune-stimulating bispecific RNA, inducing apoptosis and anti-tumor immunity in cancer cells., PMID:38380254

PLK1 phosphorylates RhoGDI1 and promotes cancer cell migration and invasion., PMID:38355643

Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma., PMID:38341177

Onvansertib in Combination with FOLFIRI and Bevacizumab in Second-Line Treatment of KRAS-Mutant Metastatic Colorectal Cancer: A Phase Ib Clinical Study., PMID:38231047

Genetic and immune microenvironment characterization of HER2-positive gastric cancer: Their association with response to trastuzumab-based treatment., PMID:36916290

Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively., PMID:36711980

HER-2-mediated nano-delivery of molecular targeted drug potently suppresses orthotopic epithelial ovarian cancer and metastasis., PMID:35995316

Multiomics characterization implicates PTK7 in ovarian cancer EMT and cell plasticity and offers strategies for therapeutic intervention., PMID:35977930

Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1., PMID:35956818

Development of a nanoparticle-based immunotherapy targeting PD-L1 and PLK1 for lung cancer treatment., PMID:35871223

Identification of polo-like kinase 1 as a therapeutic target in murine lupus., PMID:35024139

Conserved Mitotic Phosphorylation of a Proteasome Subunit Regulates Cell Proliferation., PMID:34831298

Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies., PMID:34625423

Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer., PMID:33990570

In search for biomarkers and potential drug targets for uterine serous endometrial cancer., PMID:33754208

STK39 is a novel kinase contributing to the progression of hepatocellular carcinoma by the PLK1/ERK signaling pathway., PMID:33500714

Emerging drugs for the treatment of chronic myelomonocytic leukemia., PMID:33280448

CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy., PMID:33208369

Polo-like Kinase 1 as an emerging drug target: structure, function and therapeutic implications., PMID:32886539

Developing an Arrayed CRISPR-Cas9 Co-Culture Screen for Immuno-Oncology Target ID., PMID:32375580

PLK1 and EGFR targeted nanoparticle as a radiation sensitizer for non-small cell lung cancer., PMID:31563561

Albatross/FBF1 contributes to both centriole duplication and centrosome separation., PMID:30318703

7-O-Methylwogonin from Scutellaria baicalensis Disturbs Mitotic Progression by Inhibiting Plk1 Activity in Hep3B Cells., PMID:30199903

Immunohistochemical expression of polo-like kinase 1 in oral squamous cell carcinoma and oral submucous fibrosis., PMID:29652009

Systemic Administration of siRNA with Anti-HB-EGF Antibody-Modified Lipid Nanoparticles for the Treatment of Triple-Negative Breast Cancer., PMID:29502423

Progesterone Receptor Membrane Component 1 suppresses the p53 and Wnt/β-catenin pathways to promote human pluripotent stem cell self-renewal., PMID:29445107

Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer., PMID:29391599

The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation., PMID:29170437

The screening and analysis of protein signatures and signaling associated with chemoresistance based on Protein Pathway Array technology in gastric cancer., PMID:29115543

Inhibition of Suicidal Erythrocyte Death by Volasertib., PMID:29035889

A novel immunofluorescence method to visualize microtubules in the antiparallel overlaps of microtubule-plus ends in the anaphase and telophase midzone., PMID:28942021

Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis., PMID:28692064

Nutriproteomic Analysis of Hwangmaemok-Induced Antiangiogenic Effect Using Antibody-Arrayed Protein Chip Assay., PMID:28581882

A Brief Report of Immunohistochemical Markers to Identify Aggressive Hepatoblastoma., PMID:28187036

Targeted Treatment of Metastatic Breast Cancer by PLK1 siRNA Delivered by an Antioxidant Nanoparticle Platform., PMID:28138033

Expression of genes encoding centrosomal proteins and the humoral response against these proteins in chronic myeloid leukemia., PMID:27840977

Geldanamycin, an inhibitor of Hsp90, increases paclitaxel-mediated toxicity in ovarian cancer cells through sustained activation of the p38/H2AX axis., PMID:27629142

Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes., PMID:27503460

Integrin signaling via FAK-Src controls cytokinetic abscission by decelerating PLK1 degradation and subsequent recruitment of CEP55 at the midbody., PMID:27127172

Sialic Acid-Targeted Nanovectors with Phenylboronic Acid-Grafted Polyethylenimine Robustly Enhance siRNA-Based Cancer Therapy., PMID:27007621

The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation., PMID:26912231

Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells., PMID:26573800

Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice., PMID:26185128

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-PLK1 Polyclonal Antibody [PHE97401]
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