Catalog No.
PHE92401
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ARHGDIB (Asn66-Glu201).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
ARHGDIB, Rho-GDI beta, Rho GDP-dissociation inhibitor 2, RAP1GN1, Rho GDI 2, GDIA2, GDID4, Ly-GDI
Purification
Purified by antigen affinity column.
Accession
P52566
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
SARS-CoV-2 mRNA vaccination is not associated with the induction of anti-HLA or non-HLA antibodies., PMID:35835296
Comparison of Two Strategies to Generate Antigen-Specific Human Monoclonal Antibodies: Which Method to Choose for Which Purpose?, PMID:34017336
Causes of Positive Pretransplant Crossmatches in the Absence of Donor-Specific Anti-Human Leukocyte Antigen Antibodies: A Single-Center Experience., PMID:33536364
ARHGDIB and AT1R autoantibodies are differentially related to the development and presence of chronic antibody-mediated rejection and fibrosis in kidney allografts., PMID:33358038
A Review on the Function and Regulation of ARHGDIB/RhoGDI2 Expression Including the Hypothetical Role of ARHGDIB/RhoGDI2 Autoantibodies in Kidney Transplantation., PMID:32548242
Antibodies Against ARHGDIB and ARHGDIB Gene Expression Associate With Kidney Allograft Outcome., PMID:31651716
Anti-D4GDI antibodies activate platelets in vitro: a possible link with thrombocytopenia in primary antiphospholipid syndrome., PMID:31262358
Antibodies against ARHGDIB are associated with long-term kidney graft loss., PMID:31194283
Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor Ly-GDI in platelet function: a spatial systems approach., PMID:28148498
Protective Role of Rho Guanosine Diphosphate Dissociation Inhibitor, Ly-GDI, in Pulmonary Alveolitis., PMID:26469087
Autoantibodies specific to D4GDI modulate Rho GTPase mediated cytoskeleton remodeling and induce autophagy in T lymphocytes., PMID:25623267
RNA interference-mediated knockdown of RhoGDI2 induces the migration and invasion of human lung cancer A549 cells via activating the PI3K/Akt pathway., PMID:25266803
RhoGDI2 promotes epithelial-mesenchymal transition via induction of Snail in gastric cancer cells., PMID:24721928
Association of D4-GDI expression with breast cancer progression., PMID:22674302
Differential proteomic analysis of lymphocytes treated with mycophenolic acid reveals caspase 3-induced cleavage of rho GDP dissociation inhibitor 2., PMID:19214148
Dramatic caspase-dependent apoptosis in antibody-enhanced dengue virus infection of human mast cells., PMID:18809735
Altered cellular immunity in transgenic mice with T cell-specific expression of human D4-guanine diphosphate-dissociation inhibitor (D4-GDI)., PMID:18689726
Cloning and characterization of bovine low molecular weight GTPases (Rac1 and Rac2) and rho GDP-dissociation inhibitor 2 (D4-GDI)., PMID:10802295
Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation., PMID:10664460
Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity., PMID:9490022
Inhibition of CPP32 blocks surface IgM-mediated apoptosis and D4-GDI cleavage in human BL60 Burkitt lymphoma cells., PMID:9485209
Immune responses in mice deficient in Ly-GDI, a lymphoid-specific regulator of Rho GTPases., PMID:9307064
Targeted disruption of guanosine diphosphate-dissociation inhibitor for Rho-related proteins, GDID4: normal hematopoietic differentiation but subtle defect in superoxide production by macrophages derived from in vitro embryonal stem cell differentiation., PMID:8839868
D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis., PMID:8626669
For research use only. Not for human or drug use.
