Anti-Human CXCL5/ENA-78 Polyclonal Antibody

Catalog No.

PHE38101

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CXCL5/ENA-78 (Gly57-Asn114).

Applications

ELISA, IHC, WB

Recommended Dilution

Application	Dilution
ELISA	1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

C-X-C motif chemokine 5, ENA-78(1-78), Neutrophil-activating peptide ENA-78, ENA78, SCYB5, Small-inducible cytokine B5, CXCL5, Epithelial-derived neutrophil-activating protein 78

Purification

Purified by antigen affinity column.

Accession

P42830

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Note

For research use only.

EMT-mediated regulation of CXCL1/5 for resistance to anti-EGFR therapy in colorectal cancer., PMID:35173310

Toripalimab Plus Paclitaxel and Carboplatin as Neoadjuvant Therapy in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma., PMID:35305102

Immune Response to LinB13, a Lutzomyia Intermedia Salivary Protein Correlates With Disease Severity in Tegumentary Leishmaniasis., PMID:35385578

KIF4A promotes tumor progression of bladder cancer via CXCL5 dependent myeloid-derived suppressor cells recruitment., PMID:35399116

CXCL5-mediated accumulation of mature neutrophils in lung cancer tissues impairs the differentiation program of anticancer CD8 T cells and limits the efficacy of checkpoint inhibitors., PMID:35402081

Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19., PMID:35479098

On the issue of diagnostic value of determining the level of receptors and their ligands in blood in non-small cell lung cancer., PMID:35613346

[CXCL5 inhibits tumor immune of lung cancer via modulating PD1/PD-L1 signaling]., PMID:35615793

Soluble factors secreted by human Wharton's jelly mesenchymal stromal/stem cells exhibit therapeutic radioprotection: A mechanistic study with integrating network biology., PMID:35722198

Differential Contribution of NF-κB Signaling Pathways to CD4+ Memory T Cell Induced Activation of Endothelial Cells., PMID:35769477

CXCR2 Is Essential for Radiation-Induced Intestinal Injury by Initiating Neutrophil Infiltration., PMID:35879949

Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models., PMID:35951441

ADSCs stimulated by resistin promote breast cancer cell malignancy via CXCL5 in a breast cancer coculture model., PMID:36104403

Annexin A2 regulates Mycoplasma bovis adhesion and invasion to embryo bovine lung cells affecting molecular expression essential to inflammatory response., PMID:36159852

Diminished PD-L1 regulation along with dysregulated T lymphocyte subsets and chemokine in ANCA-associated vasculitis., PMID:36219364

Dampened Inflammation and Improved Survival After CXCL5 Administration in Murine Lupus via Myeloid and Neutrophil Pathways., PMID:36240108

Targeting tumour-intrinsic N7-methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy., PMID:36283801

Immunomodulatory effects of β-defensin 2 on macrophages induced immuno-upregulation and their antitumor function in breast cancer., PMID:36324077

Protein kinase Cι mediates immunosuppression in lung adenocarcinoma., PMID:36383684

TLR5 agonists enhance anti-tumor immunity and overcome resistance to immune checkpoint therapy., PMID:36635337

Platelet Response to Allergens, CXCL10, and CXCL5 in the Context of Asthma., PMID:36820311

Modulation of low-dose ozone and LPS exposed acute mouse lung inflammation by IF1 mediated ATP hydrolysis inhibitor, BTB06584., PMID:36993977

Skeletonema marinoi Extracts and Associated Carotenoid Fucoxanthin Downregulate Pro-Angiogenic Mediators on Prostate Cancer and Endothelial Cells., PMID:37048126

Apatinib remodels the immunosuppressive tumor ecosystem of gastric cancer enhancing anti-PD-1 immunotherapy., PMID:37097818

IL-36α inhibits melanoma by inducing pro-inflammatory polarization of macrophages., PMID:37318520

CXCL5 suppression recovers neovascularization and accelerates wound healing in diabetes mellitus., PMID:37420254

HMGB1, a potential regulator of tumor microenvironment in KSHV-infected endothelial cells., PMID:37520371

Inducible nitric oxide synthase (iNOS)-activated Cxcr2 signaling in myeloid cells promotes TGFβ-dependent squamous cell carcinoma lung metastasis., PMID:37524225

Exercise training inhibits macrophage-derived IL-17A-CXCL5-CXCR2 inflammatory axis to attenuate pulmonary fibrosis in mice exposed to silica., PMID:37611700

Eggerthella lenta augments preclinical autoantibody production and metabolic shift mimicking senescence in arthritis., PMID:37656793

CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation., PMID:37709757

Expression of Inflammatory Genes in Murine Lungs in a Model of Experimental Pulmonary Hypertension: Effects of an Antibody-Based Targeted Delivery of Interleukin-9., PMID:38247549

Neutrophils are indispensable for adverse cardiac remodeling in heart failure., PMID:38387309

Serum levels of CXCL5 are decreased and correlate with circulating platelet counts in systemic lupus erythematosus., PMID:38439196

Immunological Signatures in Blood and Urine in 80 Individuals Hospitalized during the Initial Phase of COVID-19 Pandemic with Quantified Nicotine Exposure., PMID:38612525

Concomitant NAFLD Facilitates Liver Metastases and PD-1-Refractory by Recruiting MDSCs via CXCL5/CXCR2 in Colorectal Cancer., PMID:38724007

Intervention of CXCL5 attenuated neuroinflammation and promoted neurological recovery after traumatic brain injury., PMID:38739900

Insights into Therapeutic Response Prediction for Ustekinumab in Ulcerative Colitis Using an Ensemble Bioinformatics Approach., PMID:38791570

Distinct inflammatory markers in primary and secondary dengue infection: can cytokines CXCL5, CXCL9, and CCL17 act as surrogate markers?, PMID:38884301

CXCL5 impedes CD8+ T cell immunity by upregulating PD-L1 expression in lung cancer via PXN/AKT signaling phosphorylation and neutrophil chemotaxis., PMID:39034411

Dialog between mantle cell lymphoma cells and lymphoma-associated macrophages underlies ibrutinib resistance., PMID:39168245

CXCL5 inhibition improves kidney function by protecting renal tubular epithelial cells in diabetic kidney disease., PMID:39326648

IL-17A-neutralizing antibody ameliorates inflammation and fibrosis in rosacea by antagonizing the CXCL5/CXCR2 axis., PMID:39370827

Effect of tocilizumab on endothelial and platelet-derived CXC-chemokines and their association with inflammation and myocardial injury in STEMI patients undergoing primary PCI., PMID:39374793

A human tissue-based model of renal inflammation., PMID:39476943

The Clinical and Molecular Response of Pyoderma Gangrenosum to IL-23 Blockade: Result from a Proof-of-Concept Open-Label Clinical Trial., PMID:39547392

Tumor-derived CCL15 regulates RNA m6A methylation in cancer-associated fibroblasts to promote hepatocellular carcinoma growth., PMID:39734010

The impact of bevacizumab intraperitoneal perfusion combined with paclitaxel and platinum-based chemotherapy on serum stromal-derived factor-1α (SDF-1α) and chemokine ligand 5 (CXCL-5) levels in patients with ovarian cancer after tumor cell debulking surgery., PMID:39757759

Modulating the CXCR2 Signaling Axis Using Engineered Chemokine Fusion Proteins to Disrupt Myeloid Cell Infiltration in Pancreatic Cancer., PMID:40427538

Adipose-Derived Mesenchymal Stromal/Stem Cells Reduce Inflammatory Responses and Partially Alleviate Skin Symptoms in Imiquimod-Induced Psoriasis-Like Dermatitis Model Mice., PMID:40500215

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