Catalog No.
PHA70801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CD258/TNFSF14/LIGHT (Asp74-Val240).
Applications
ELISA, IHC, WB
Recommended Dilution
| Application |
Dilution |
| ELISA |
1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000 |
Target
Herpes virus entry mediator ligand, LIGHT, CD258, HVEM-L, HVEML, TNFSF14, Tumor necrosis factor ligand superfamily member 14, Herpesvirus entry mediator ligand
Purification
Purified by antigen affinity column.
Accession
O43557
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note
For research use only.
Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway., PMID:10700230
Costimulatory wars: the tumor menace., PMID:11007364
LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response., PMID:10754304
The three HveA receptor ligands, gD, LT-alpha and LIGHT bind to distinct sites on HveA., PMID:11164894
Recombinant, soluble LIGHT (HVEM ligand) induces increased IL-8 secretion and growth arrest in A375 melanoma cells., PMID:11429164
Mouse T cells receive costimulatory signals from LIGHT, a TNF family member., PMID:12384428
LIGHT, a new member of the TNF superfamily., PMID:12456019
The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death., PMID:12566458
A role for the lymphotoxin/LIGHT axis in the pathogenesis of murine collagen-induced arthritis., PMID:12816989
Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy., PMID:15067315
The effect of LIGHT in inducing maturation of monocyte-derived dendritic cells from MDS patients., PMID:15103504
[Eukaryotic expression of human LIGHT-Fc chimeric molecule and its anti-tumor activity]., PMID:15169669
Attenuation of graft arterial disease by manipulation of the LIGHT pathway., PMID:15178556
LIGHT costimulates CD40 triggering and induces immunoglobulin secretion; a novel key partner in T cell-dependent B cell terminal differentiation., PMID:15549770
LIGHT enhances the bactericidal activity of human monocytes and neutrophils via HVEM., PMID:16275888
Inhibition of lymphotoxin-beta receptor-mediated cell death by survivin-DeltaEx3., PMID:16540654
LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis., PMID:16649193
Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure., PMID:16934497
LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes., PMID:17393389
Targeting lymphotoxin beta receptor with tumor-specific T lymphocytes for tumor regression., PMID:17785576
Platelet-associated LIGHT (TNFSF14) mediates adhesion of platelets to human vascular endothelium., PMID:17938804
From gene expression to serum proteins: biomarker discovery in ankylosing spondylitis., PMID:19103635
Characterization of herpes virus entry mediator as a factor linked to obesity., PMID:19680232
Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT., PMID:21959263
Serum-soluble herpes virus entry mediator levels reflect disease severity and Th2 environment in cutaneous T-cell lymphoma., PMID:23306973
Reverse signaling from LIGHT promotes pro-inflammatory responses in the human monocytic leukemia cell line, THP-1., PMID:24044961
Therapeutic blockade of LIGHT interaction with herpesvirus entry mediator and lymphotoxin β receptor attenuates in vivo cytotoxic allogeneic responses., PMID:25226173
The Tumor Necrosis Factor Superfamily Molecule LIGHT Promotes Keratinocyte Activity and Skin Fibrosis., PMID:25789702
A Randomized Phase 1 Study to Assess the Safety and Pharmacokinetics of the Subcutaneously Injected Anti-LIGHT Antibody, SAR252067., PMID:27545119
Skewing toward Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis., PMID:28155222
DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression., PMID:28560426
LIGHT-HVEM signaling in keratinocytes controls development of dermatitis., PMID:29339444
LIGHT/TNFSF14 as a New Biomarker of Bone Disease in Multiple Myeloma Patients Experiencing Therapeutic Regimens., PMID:30405638
Unique Sjögren's syndrome patient subsets defined by molecular features., PMID:31497844
Shedding "LIGHT" on the Link between Bone and Fat in Obese Children and Adolescents., PMID:32635185
Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS., PMID:32817460
Randomized, double-blind, controlled trial of human anti-LIGHT monoclonal antibody in COVID-19 acute respiratory distress syndrome., PMID:34871182
For research use only. Not for human or drug use.
