Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb., PMID:40055364
Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb., PMID:40055364
Incident Vertebral Fractures During Romosozumab Treatment in a Patient With a Pathogenic LRP5 Variant., PMID:39726666
Incident Vertebral Fractures During Romosozumab Treatment in a Patient With a Pathogenic LRP5 Variant., PMID:39726666
Pharmacogenomics of clinical response to Natalizumab in multiple sclerosis: a genome-wide multi-centric association study., PMID:39264442
Pharmacogenomics of clinical response to Natalizumab in multiple sclerosis: a genome-wide multi-centric association study., PMID:39264442
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells., PMID:38713511
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells., PMID:38713511
Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification., PMID:38358799
Vitiligo progression in a patient undergoing romosozumab treatment for osteoporosis., PMID:37965188
Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification., PMID:38358799
Wnt Signaling Activation in Gingival Epithelial Cells and Macrophages of Experimental Periodontitis., PMID:37232780
Wnt Signaling Activation in Gingival Epithelial Cells and Macrophages of Experimental Periodontitis., PMID:37232780
Multi-Targeting DKK1 and LRP6 Prevents Bone Loss and Improves Fracture Resistance in Multiple Myeloma., PMID:36987921
Multi-Targeting DKK1 and LRP6 Prevents Bone Loss and Improves Fracture Resistance in Multiple Myeloma., PMID:36987921
Canonical Wnt signaling activation by chimeric antigen receptors for efficient cardiac differentiation from mouse embryonic stem cells., PMID:36765434
Canonical Wnt signaling activation by chimeric antigen receptors for efficient cardiac differentiation from mouse embryonic stem cells., PMID:36765434
Targeting Sclerostin and Dkk1 at Optimized Proportions of Low-Dose Antibody Achieves Similar Skeletal Benefits to Higher-Dose Sclerostin Targeting in the Mature Adult and Aged Skeleton., PMID:36465166
The female syndecan-4-/- heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels., PMID:36092718
The female syndecan-4-/- heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels., PMID:36092718
Robust Colonic Epithelial Regeneration and Amelioration of Colitis via FZD-Specific Activation of Wnt Signaling., PMID:35569814
Robust Colonic Epithelial Regeneration and Amelioration of Colitis via FZD-Specific Activation of Wnt Signaling., PMID:35569814
Anti-β2-GPI Antibodies Induce Endothelial Cell Expression of Tissue Factor by LRP6 Signal Transduction Pathway Involving Lipid Rafts., PMID:35455968
Anti-β2-GPI Antibodies Induce Endothelial Cell Expression of Tissue Factor by LRP6 Signal Transduction Pathway Involving Lipid Rafts., PMID:35455968
Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation., PMID:35418614
Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation., PMID:35418614
Endothelial Unc5B controls blood-brain barrier integrity., PMID:35246514
Endothelial Unc5B controls blood-brain barrier integrity., PMID:35246514
Pathogenic Role of Diabetes-Induced Overexpression of Kallistatin in Corneal Wound Healing Deficiency Through Inhibition of Canonical Wnt Signaling., PMID:35044447
Pathogenic Role of Diabetes-Induced Overexpression of Kallistatin in Corneal Wound Healing Deficiency Through Inhibition of Canonical Wnt Signaling., PMID:35044447
Soluble very low-density lipoprotein receptor (sVLDLR) inhibits fibrosis in neovascular age-related macular degeneration., PMID:34820908
7-Hydroxycoumarin mitigates the severity of collagen-induced arthritis in rats by inhibiting proliferation and inducing apoptosis of fibroblast-like synoviocytes via suppression of Wnt/β-catenin signaling pathway., PMID:34752968
7-Hydroxycoumarin mitigates the severity of collagen-induced arthritis in rats by inhibiting proliferation and inducing apoptosis of fibroblast-like synoviocytes via suppression of Wnt/β-catenin signaling pathway., PMID:34752968
LRPs in WNT Signalling., PMID:34490514
LRPs in WNT Signalling., PMID:34490514
Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex., PMID:34431536
Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex., PMID:34431536
Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells., PMID:33331818
Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells., PMID:33331818
Unlike LGR4, LGR5 potentiates Wnt-β-catenin signaling without sequestering E3 ligases., PMID:33262293
Unlike LGR4, LGR5 potentiates Wnt-β-catenin signaling without sequestering E3 ligases., PMID:33262293
Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration., PMID:33164872
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo., PMID:32818433
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo., PMID:32818433
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling., PMID:32762848
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling., PMID:32762848
One-pot synthesis of heterodimeric agonists that activate the canonical Wnt signaling pathway., PMID:32119023
One-pot synthesis of heterodimeric agonists that activate the canonical Wnt signaling pathway., PMID:32119023
EHD1 impairs decidualization by regulating the Wnt4/β-catenin signaling pathway in recurrent implantation failure., PMID:31707150
EHD1 impairs decidualization by regulating the Wnt4/β-catenin signaling pathway in recurrent implantation failure., PMID:31707150
Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice., PMID:31452509
Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice., PMID:31452509
Mycoplasma hyorhinis infection promotes gastric cancer cell motility via β-catenin signaling., PMID:31321908
Mycoplasma hyorhinis infection promotes gastric cancer cell motility via β-catenin signaling., PMID:31321908
Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells., PMID:30664649
Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells., PMID:30664649
Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis., PMID:30406034
Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis., PMID:30406034
Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes., PMID:30019207
Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes., PMID:30019207
FGF23 Regulates Wnt/β-Catenin Signaling-Mediated Osteoarthritis in Mice Overexpressing High-Molecular-Weight FGF2., PMID:29718273
FGF23 Regulates Wnt/β-Catenin Signaling-Mediated Osteoarthritis in Mice Overexpressing High-Molecular-Weight FGF2., PMID:29718273
Anti-angiogenic effect of a humanized antibody blocking the Wnt/β-catenin signaling pathway., PMID:29630973
Effects of pharmacologic sclerostin inhibition or testosterone administration on soleus muscle atrophy in rodents after spinal cord injury., PMID:29579075
Effects of pharmacologic sclerostin inhibition or testosterone administration on soleus muscle atrophy in rodents after spinal cord injury., PMID:29579075
DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation., PMID:29431745
Cell-type specific potent Wnt signaling blockade by bispecific antibody., PMID:29335534
Cell-type specific potent Wnt signaling blockade by bispecific antibody., PMID:29335534
Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase., PMID:28966723
Bone Marrow Mesenchymal Stem Cell-Derived CD63+ Exosomes Transport Wnt3a Exteriorly and Enhance Dermal Fibroblast Proliferation, Migration, and Angiogenesis In Vitro., PMID:28679315
Bone Marrow Mesenchymal Stem Cell-Derived CD63+ Exosomes Transport Wnt3a Exteriorly and Enhance Dermal Fibroblast Proliferation, Migration, and Angiogenesis In Vitro., PMID:28679315
Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo., PMID:28425175
Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo., PMID:28425175
LRP5: From bedside to bench to bone., PMID:28341377
Long noncoding RNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) inhibits proliferation and invasion of glioma cells by suppressing the Wnt/β-catenin signaling pathway., PMID:28187755
Connective Tissue Growth Factor Domain 4 Amplifies Fibrotic Kidney Disease through Activation of LDL Receptor-Related Protein 6., PMID:28130402
Carcinogenicity risk assessment of romosozumab: A review of scientific weight-of-evidence and findings in a rat lifetime pharmacology study., PMID:27569204
Carcinogenicity risk assessment of romosozumab: A review of scientific weight-of-evidence and findings in a rat lifetime pharmacology study., PMID:27569204
Application of anti-Sclerostin therapy in non-osteoporosis disease models., PMID:27780792
The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6., PMID:27558933
The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6., PMID:27558933
Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells., PMID:27486054
Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth., PMID:27401612
Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth., PMID:27401612
CKAP4 is a Dickkopf1 receptor and is involved in tumor progression., PMID:27322059
CKAP4 is a Dickkopf1 receptor and is involved in tumor progression., PMID:27322059
Do signal transduction cascades influence survival in triple-negative breast cancer? A preliminary study., PMID:27307757
Do signal transduction cascades influence survival in triple-negative breast cancer? A preliminary study., PMID:27307757
For research use only. Not for human or drug use.
