Anti-MRE11 Polyclonal Antibody

Catalog No.

PHE73901

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human MRE11 (Pro375-Lys609).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

HNGS1,Double-strand break repair protein MRE11,MRE11A,Double-strand break repair protein MRE11A,Meiotic recombination 11 homolog A,MRE11 homolog A,MRE11 homolog 1,MRE11,Meiotic recombination 11 homolog 1

Concentration

3.44 mg/ml

Purification

Purified by antigen affinity column.

Accession

P49959

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Analysis of MRE11 and Mortality Among Adults With Muscle-Invasive Bladder Cancer Managed With Trimodality Therapy., PMID:36383379

Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells., PMID:36209798

DNA damage and repair in the visual center in the rhesus monkey model of glaucoma., PMID:35364099

Multiple DSB Resection Activities Redundantly Promote Alternative End Joining-Mediated Class Switch Recombination., PMID:34926456

Topological Analysis of γH2AX and MRE11 Clusters Detected by Localization Microscopy during X-ray-Induced DNA Double-Strand Break Repair., PMID:34771723

MRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner., PMID:33927349

Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment., PMID:32778095

Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly., PMID:32358495

GFI1's role in DNA repair suggests implications for tumour cell response to treatment., PMID:31225488

Identification and characterization of a novel nuclear structure containing members of the homologous recombination and DNA damage response pathways., PMID:30553479

Sensitivity of CD3/CD28-stimulated versus non-stimulated lymphocytes to ionizing radiation and genotoxic anticancer drugs: key role of ATM in the differential radiation response., PMID:30323167

Localization Microscopy Analyses of MRE11 Clusters in 3D-Conserved Cell Nuclei of Different Cell Lines., PMID:29361783

Antibodies against the mono-methylated arginine-glycine repeat (MMA-RG) of the Epstein-Barr virus nuclear antigen 2 (EBNA2) identify potential cellular proteins targeted in viral transformation., PMID:28758620

Studies of the DNA Damage Response by Using the Lac Operator/Repressor (LacO/LacR) Tethering System., PMID:28477125

Telomere Dysfunction Induced Foci (TIF) Analysis., PMID:27500188

Development of a multiparameter flow cytometric assay as a potential biomarker for homologous recombination deficiency in women with high-grade serous ovarian cancer., PMID:26198537

Targeting of the EGFR/β1 integrin connecting proteins PINCH1 and Nck2 radiosensitizes three-dimensional SCC cell cultures., PMID:26004008

Identification of Plasmodium falciparum DNA Repair Protein Mre11 with an Evolutionarily Conserved Nuclease Function., PMID:25938776

Phosphorylation of PTEN at STT motif is associated with DNA damage response., PMID:25771877

Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins., PMID:25605897

Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation., PMID:25485873

APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination., PMID:25404348

The human SRCAP chromatin remodeling complex promotes DNA-end resection., PMID:25176633

Smad7 enhances ATM activity by facilitating the interaction between ATM and Mre11-Rad50-Nbs1 complex in DNA double-strand break repair., PMID:25063542

Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up., PMID:23849169

The MRN-CtIP pathway is required for metaphase chromosome alignment., PMID:23434370

SMC1-mediated intra-S-phase arrest facilitates bocavirus DNA replication., PMID:23365434

Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching., PMID:23254285

Differential activation of cellular DNA damage responses by replication-defective and replication-competent adenovirus mutants., PMID:23015708

Mre11 is expressed in mammalian mitochondria where it binds to mitochondrial DNA., PMID:21677273

Activation of protein kinase Tel1 through recognition of protein-bound DNA ends., PMID:21402778

L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1., PMID:21297581

Autophosphorylation and ATM activation: additional sites add to the complexity., PMID:21149446

Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex., PMID:20943970

Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVID., PMID:20805886

Loss of juxtaposition of RAG-induced immunoglobulin DNA ends is implicated in the precursor B-cell differentiation defect in NBS patients., PMID:20378756

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair., PMID:20081839

Temporal regulation of Ig gene diversification revealed by single-cell imaging., PMID:19748985

Multiple functions of MRN in end-joining pathways during isotype class switching., PMID:19633670

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination., PMID:19629035

Meiotic localization of Mre11 and Rad50 in wild type, spo11-1, and MRN complex mutants of Coprinus cinereus., PMID:19396455

Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes., PMID:19180185

A tool for enhancement and scoring of DNA repair foci., PMID:18836995

Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites., PMID:18582474

Cadmium inhibits non-homologous end-joining and over-activates the MRE11-dependent repair pathway., PMID:18539077

Transcriptional profile of the homologous recombination machinery and characterization of the EhRAD51 recombinase in response to DNA damage in Entamoeba histolytica., PMID:18402694

Mechanism and regulation of class switch recombination., PMID:18370922

The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldarius., PMID:18294364

Cytological analysis of MRE11 protein during early meiotic prophase I in Arabidopsis and tomato., PMID:18293007

DNA double-strand break repair defects in syndromes associated with acute radiation response: at least two different assays to predict intrinsic radiosensitivity?, PMID:18246480

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