Catalog No.
PHE48201
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CDKN1B (Met1-Thr198).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Cyclin-dependent kinase inhibitor 1B,KIP1,CDKN1B,p27Kip1,Cyclin-dependent kinase inhibitor p27
Purification
Purified by antigen affinity column.
Accession
P46527
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Green tea EGCG inhibits naïve CD4+ T cell division and progression in mice: An integration of network pharmacology, molecular docking and experimental validation., PMID:37441168
Anti-Proliferative Effect of Radiotherapy and Implication of Immunotherapy in Anaplastic Thyroid Cancer Cells., PMID:37374179
HER2 as a potential therapeutic target on quiescent prostate cancer cells., PMID:36805918
Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung., PMID:33731112
Prolonged cetuximab treatment promotes p27Kip1-mediated G1 arrest and autophagy in head and neck squamous cell carcinoma., PMID:33664437
Down-regulation of RCC1 sensitizes immunotherapy by up-regulating PD-L1 via p27kip1 /CDK4 axis in non-small cell lung cancer., PMID:33630417
Real world clinicopathologic observations of patients with metastatic solid tumors receiving immune checkpoint inhibitor therapy: Analysis from Kentucky Cancer Registry., PMID:33619913
Expression of p27 and p16 and their clinical significance in gastric cancer., PMID:32880047
Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes., PMID:32584970
A BAP31 intrabody induces gastric cancer cell death by inhibiting p27kip1 proteasome degradation., PMID:30338855
Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinoma., PMID:29278708
Cyclin D1, Ret and P27 Expression in Papillary Thyroid Microcarcinoma., PMID:29120119
Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells., PMID:29100552
Cell type-specific effects of p27KIP1 loss on retinal development., PMID:28931408
Cellular interactions of the phosphorylated form of AKT in prostate cancer., PMID:28300578
Genomics of Hairy Cell Leukemia., PMID:28297625
miR-222 induces Adriamycin resistance in breast cancer through PTEN/Akt/p27kip1 pathway., PMID:27699665
WNT/β-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary., PMID:26939755
Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment., PMID:26935956
The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1., PMID:26684356
Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27., PMID:26223520
Cell cycle and apoptosis regulatory proteins, proliferative markers, cell signaling molecules, CD209, and decorin immunoreactivity in low-grade myxofibrosarcoma and myxoma., PMID:25940995
MicroRNA signature characterizes primary tumors that metastasize in an esophageal adenocarcinoma rat model., PMID:25826212
Evidence of an oncogenic role of aberrant TOX activation in cutaneous T-cell lymphoma., PMID:25548321
Bone marrow stromal cells protect acute myeloid leukemia cells from anti-CD44 therapy partly through regulating PI3K/Akt-p27(Kip1) axis., PMID:25408361
Immunohistochemical expression of p27(kip1) in metastatic laryngeal squamous cell carcinoma., PMID:25323759
No evidence of cell cycle dysregulation in mantle cell lymphoma in vivo., PMID:25315075
The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK+ anaplastic large cell lymphoma., PMID:25145835
Transforming growth factor β1 increases p27 levels via synthesis and degradation mechanisms in the hyperproliferative gastric epithelium in rats., PMID:25000203
p27 variant and corticotropinoma susceptibility: a genetic and in vitro study., PMID:24532476
The anti-erbB3 antibody MM-121/SAR256212 in combination with trastuzumab exerts potent antitumor activity against trastuzumab-resistant breast cancer cells., PMID:24215614
FGFR1 signaling stimulates proliferation of human mesenchymal stem cells by inhibiting the cyclin-dependent kinase inhibitors p21(Waf1) and p27(Kip1)., PMID:23939995
Expression of p27Kip1 protein in gastric carcinoma., PMID:23858559
Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics., PMID:23770079
Overexpression of CDKN1B inhibits fibroblast proliferation in a rabbit model of experimental glaucoma filtration surgery., PMID:23233251
Transgenesis-mediated reproductive dysfunction and tumorigenesis: effects of immunological neutralization., PMID:23226476
MYC expression and distribution in normal mature lymphoid cells., PMID:23165652
Depletion of SUMO ligase hMMS21 impairs G1 to S transition in MCF-7 breast cancer cells., PMID:22906975
Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium., PMID:22855803
HDAC1 inactivation induces mitotic defect and caspase-independent autophagic cell death in liver cancer., PMID:22496786
Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway., PMID:22426400
All-trans retinoic acid inhibits mesangial cell proliferation by up-regulating p21Waf1/Cip1 and p27Kip1 and down-regulating Skp2., PMID:22344541
Antibody Microarray Analysis of Signaling Networks Regulated by Cxcl13 and Cxcr5 in Prostate Cancer., PMID:24009409
Cyclin A2 mutagenesis analysis: a new insight into CDK activation and cellular localization requirements., PMID:21829545
Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans., PMID:21501079
Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro., PMID:21317921
[Prognostic significance of Skp2 and p27(kip) in diffuse large B cell lymphoma]., PMID:21258183
Growth suppression of human hepatocellular carcinoma xenografts by a monoclonal antibody CH12 directed to epidermal growth factor receptor variant III., PMID:21163950
The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia., PMID:20823107
Evidence that FOXO3a is involved in oocyte apoptosis in the neonatal rat ovary., PMID:20651833
For research use only. Not for human or drug use.
