Catalog No.
RHC19201
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
T cell-specific protein-tyrosine kinase, LSK, LCK, Protein YT16, p56-LCK, Tyrosine-protein kinase Lck, Lymphocyte cell-specific protein-tyrosine kinase, Proto-oncogene Lck, Leukocyte C-terminal Src kinase
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P06239
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1559
The immunosuppressive effect of glucocorticoids in human primary T cells is mainly mediated via a rapid inhibition of the IL-2/IL-2R signaling axis., PMID:40468327
Asiaticoside enhances the anti-tumor effect of anti-PDL1 by regulating T cell activity through increasing LCK activity., PMID:40373489
A novel IgD-FcδR blocker, IgD-Fc-Ig fusion protein, effectively alleviates abnormal activation of T cells the disease progression in systemic lupus erythematosus., PMID:40194603
Deficiency of H3K27 histone demethylase UTX in T cells blunts allergic sensitization and anaphylaxis to peanut., PMID:40065718
Zika virus vaccines and monoclonal antibodies: a priority agenda for research and development., PMID:40024262
Perfluorooctane sulfonate attenuates IgE/Ag-stimulated mast cell activation and anaphylactic responses via activating SHP-1 pathway., PMID:39827624
CD28 shapes T cell receptor signaling by regulating Lck dynamics and ZAP70 activation., PMID:39776902
Allosteric Changes Underlie the Outside-In Transmission of Activatory Signals in the TCR., PMID:39754405
From TCR fundamental research to innovative chimeric antigen receptor design., PMID:39433885
Structure, function, and immunomodulation of the CD8 co-receptor., PMID:39253084
Neuropathological hallmarks in the post-mortem retina of neurodegenerative diseases., PMID:39160362
PTPN22 through the regulation of Th17/Treg balance acts as a potential target for the treatment of Graves' disease., PMID:39083881
A non-invasive nanobody probe for high precision mapping of Lck spatial distribution., PMID:39021567
Antigenic cartography using hamster sera identifies SARS-CoV-2 JN.1 evasion seen in human XBB.1.5 booster sera., PMID:38712124
B-cell receptor signaling activity identifies patients with mantle cell lymphoma at higher risk of progression., PMID:38503806
Differentially Expressed Genes Involved in Primary Resistance to Immunotherapy in Patients with Advanced-Stage Pulmonary Cancer., PMID:38396726
EGF-Receptor against Amphiregulin (AREG) Influences Costimulatory Molecules on Monocytes and T Cells and Modulates T-Cell Responses., PMID:38046264
INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control., PMID:37670137
Enolase 1 of Candida albicans binds human CD4+ T cells and modulates naïve and memory responses., PMID:37503840
IL-4Rα signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis., PMID:36599893
Molecular classification of human papillomavirus-positive cervical cancers based on immune signature enrichment., PMID:36203656
CD93 is Associated with Glioma-related Malignant Processes and Immunosuppressive Cell Infiltration as an Inspiring Biomarker of Survivance., PMID:36006582
Spatial requirements for ITAM signaling in an intracellular natural killer cell model membrane., PMID:35933027
Exploring the mechanism of berberine-mediated Tfh cell immunosuppression., PMID:35901597
S100A10 Is a New Prognostic Biomarker Related to the Malignant Molecular Features and Immunosuppression Process of Adult Gliomas., PMID:35779750
Novel strategies for the mitigation of cytokine release syndrome induced by T cell engaging therapies with a focus on the use of kinase inhibitors., PMID:35694193
Role of Programmed Cell Death Protein-1 and Lymphocyte Specific Protein Tyrosine Kinase in the Aryl Hydrocarbon Receptor- Mediated Impairment of the IgM Response in Human CD5+ Innate-Like B Cells., PMID:35558082
BCR::ABL1 tyrosine kinase inhibitors hamper the therapeutic efficacy of blinatumomab in vitro., PMID:35551463
Involvement of CD4+ and CD8+ T-lymphocytes in the modulation of nociceptive processing evoked by CCL4 in mice., PMID:34999112
Membrane prohibitin forms a dynamic complex with p56lck to regulate T cell receptor signaling., PMID:34942191
Human Cytomegalovirus Infection Promotes Expansion of a Functionally Superior Cytoplasmic CD3+ NK Cell Subset with a Bcl11b-Regulated T Cell Signature., PMID:34625521
Integrated Molecular and Immune Phenotype of HER2-Positive Breast Cancer and Response to Neoadjuvant Therapy: A NeoALTTO Exploratory Analysis., PMID:34548320
Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies., PMID:34326166
Knowledge gaps in the epidemiology of severe dengue impede vaccine evaluation., PMID:34265259
Development of a B-cell maturation antigen-specific T-cell antigen coupler receptor for multiple myeloma., PMID:34217618
Constitutive PSGL-1 Correlates with CD30 and TCR Pathways and Represents a Potential Target for Immunotherapy in Anaplastic Large T-Cell Lymphoma., PMID:34204843
Identification and Characterization of the Amphioxus Lck and Its Associated Tyrosine Phosphorylation-Dependent Inhibitory LRR Receptor., PMID:34149695
Dermatan Sulfate Is a Potential Regulator of IgH via Interactions With Pre-BCR, GTF2I, and BiP ER Complex in Pre-B Lymphoblasts., PMID:34113352
Identification of a Sensitive Human Immunological Target of Aryl Hydrocarbon Receptor Activation: CD5+ Innate-Like B Cells., PMID:33936048
An IgD-Fc-Ig fusion protein restrains the activation of T and B cells by inhibiting IgD-IgDR-Lck signaling in rheumatoid arthritis., PMID:33864023
The Effect of Nintedanib on T-Cell Activation, Subsets and Functions., PMID:33727792
The multi-kinase inhibitor TG02 induces apoptosis and blocks B-cell receptor signaling in chronic lymphocytic leukemia through dual mechanisms of action., PMID:33714981
Plasma membrane lipid scrambling causing phosphatidylserine exposure negatively regulates NK cell activation., PMID:33469162
Differentiation and activation of human CD4 T cells is associated with a gradual loss of myelin and lymphocyte protein., PMID:33345332
IgE Activates Monocytes from Cancer Patients to Acquire a Pro-Inflammatory Phenotype., PMID:33203088
Transcriptome analysis reveals potential immune function-related regulatory genes/pathways of female Lubo goat submandibular glands at different developmental stages., PMID:33083113
Src Family Protein Kinase Controls the Fate of B Cells in Autoimmune Diseases., PMID:33037966
Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia., PMID:32983140
Concomitant use of a dual Src/ABL kinase inhibitor eliminates the in vitro efficacy of blinatumomab against Ph+ ALL., PMID:32898857
Multisystem Inflammatory Syndrome in U.S. Children and Adolescents., PMID:32598831
For research use only. Not for human or drug use.
