Catalog No.
RHA80601
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Applications
ELISA
Target
CD5 antigen-like, Apoptosis inhibitor expressed by macrophages, IgM-associated peptide, CT-2, hAIM, API6, SP-alpha, CD5L
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O43866
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1515
Note
For research use only.
Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes., PMID:9064341
A role for CD5 in cognate interactions between T cells and B cells, and identification of a novel ligand for CD5., PMID:9723705
Interaction of recombinant and natural soluble CD5 forms with an alternative cell surface ligand., PMID:10427974
The identification and characterization of a ligand for bovine CD5., PMID:11207268
Biochemical characterization of recombinant and circulating human Spalpha., PMID:15009805
Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells., PMID:23562157
Stabilization and augmentation of circulating AIM in mice by synthesized IgM-Fc., PMID:24804991
The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses., PMID:25713983
Association of apoptosis inhibitor of macrophage (AIM) expression with urinary protein and kidney dysfunction., PMID:26846784
Retinal pigment epithelium and microglia express the CD5 antigen-like protein, a novel autoantigen in age-related macular degeneration., PMID:27989757
The utility of apoptosis inhibitor of macrophages as a possible diagnostic marker in patients with Crohn's disease., PMID:28284201
Prediction of Response to Sorafenib in Hepatocellular Carcinoma: A Putative Marker Panel by Multiple Reaction Monitoring-Mass Spectrometry (MRM-MS)., PMID:28550167
Activation of apoptosis inhibitor of macrophage is a sensitive diagnostic marker for NASH-associated hepatocellular carcinoma., PMID:29086016
Elevation of serum CD5L concentration is correlated with disease activity in patients with systemic lupus erythematosus., PMID:30173083
Independent modes of disease repair by AIM protein distinguished in AIM-felinized mice., PMID:30177770
The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein., PMID:30324136
Therapeutic Targeting of Apoptosis Inhibitor of Macrophage/CD5L in Sepsis., PMID:30326743
CD5L contributes to the pathogenesis of methicillin-resistant Staphylococcus aureus-induced pneumonia., PMID:30959370
Secreted IgM: New tricks for an old molecule., PMID:31302940
Crucial Role of AIM/CD5L in the Development of Glomerular Inflammation in IgA Nephropathy., PMID:32611589
The New and the Old: Platform Cross-Validation of Immunoaffinity MASS Spectrometry versus ELISA for PromarkerD, a Predictive Test for Diabetic Kidney Disease., PMID:33126588
Evolution of Fc Receptor-Like Scavenger in Mammals., PMID:33708190
CD5L as an Extracellular Vesicle-Derived Biomarker for Liquid Biopsy of Lung Cancer., PMID:33808296
The Role of Renal Macrophage, AIM, and TGF-β1 Expression in Renal Fibrosis Progression in IgAN Patients., PMID:34194427
Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators., PMID:35330909
Novel immune-related signature based on immune cells for predicting prognosis and immunotherapy response in clear cell renal cell carcinoma., PMID:35441741
Antibody therapeutics for epithelial ovarian cancer., PMID:36302510
Human coagulation factor X and CD5 antigen-like are potential new members of the zonulin family proteins., PMID:36446155
Limited Proteolysis-Mass Spectrometry Reveals Aging-Associated Changes in Cerebrospinal Fluid Protein Abundances and Structures., PMID:36741774
Macrophage CD5L is a target for cancer immunotherapy., PMID:37054630
Overcoming adaptive resistance to anti-VEGF therapy by targeting CD5L., PMID:37100807
Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD., PMID:37592330
Absolute Quantification of Pan-Cancer Plasma Proteomes Reveals Unique Signature in Multiple Myeloma., PMID:37835457
AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions., PMID:38006711
CD5L is a canonical component of circulatory IgM., PMID:38055740
Macro CD5L+ deteriorates CD8+T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma., PMID:38245530
Administration of an antibody against apoptosis inhibitor of macrophage prevents aortic aneurysm progression in mice., PMID:38982113
CD5L up-regulates the TGF-β signaling pathway and promotes renal fibrosis., PMID:39127319
CD5L associates with IgM via the J chain., PMID:39333069
Serum CD5L as potential biomarker of thyroid hormone status during pregnancy., PMID:39345206
Cryo-EM reveals structural basis for human AIM/CD5L recognition of polymeric immunoglobulin M., PMID:39477921
Distinct appearances of circulatory and secretory IgM demarcated by CD5L., PMID:40037999
Potential role of liver-resident CD3+ macrophages in HBV clearance in a mouse hepatitis B model., PMID:40143948
For research use only. Not for human or drug use.
