Catalog No.
YMG78801
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Cys27-Asn276
Predicted molecular weight
29.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
G3XA59
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lrrc32, GARP, Glycoprotein A repetitions predominant, Garpin, Leucine-rich repeat-containing protein 32, Transforming growth factor beta activator LRRC32
Reduced Deltex1 expression in T cells indicates increased disease activity in Sjögren's disease., PMID:39661563
Discovery and preclinical evaluation of BPB-101: a novel triple functional bispecific antibody targeting GARP-TGF-β complex/SLC, free TGF-β and PD-L1., PMID:39635528
Dynamic allostery drives autocrine and paracrine TGF-β signaling., PMID:39288764
The CALR mutations enhance the expression of the immunosuppressive proteins GARP and LAP on peripheral blood lymphocytes through increased binding of activated platelets., PMID:39161981
Suppression of lysosome metabolism-meditated GARP/TGF-β1 complexes specifically depletes regulatory T cells to inhibit breast cancer metastasis., PMID:38698265
A novel GARP humanized mouse model for efficacy assessment of GARP-targeting therapies., PMID:38442579
Nuclear Glycoprotein A Repetitions Predominant (GARP) Is a Common Trait of Glioblastoma Stem-like Cells and Correlates with Poor Survival in Glioblastoma Patients., PMID:38136258
TGF-β Score based on Silico Analysis can Robustly Predict Prognosis and Immunological Characteristics in Lower-grade Glioma: The Evidence from Multicenter Studies., PMID:37718518
GARP on hepatic stellate cells is essential for the development of liver fibrosis., PMID:37348791
Anti-GARP Antibodies Inhibit Release of TGF-β by Regulatory T Cells via Different Modes of Action, but Do Not Influence Their Function In Vitro., PMID:36928178
Analysis of LAP+ and GARP+ Treg subsets in peripheral blood of patients with neuromyelitis optica spectrum disorders., PMID:36683084
LRRC superfamily expression in stromal cells predicts the clinical prognosis and platinum resistance of ovarian cancer., PMID:36653841
New insight into GARP striking role in cancer progression: application for cancer therapy., PMID:36460874
Genetic Markers of Atopic Dermatitis Risk for Screening Aviation Applicants., PMID:36309799
Selective targeting of GARP-LTGFβ axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity., PMID:36096533
Leucine rich repeat containing 32 accelerates tenogenic differentiation of tendon-derived stem cells and promotes Achilles tendon repair in rats., PMID:35934780
GARP as a Therapeutic Target for the Modulation of Regulatory T Cells in Cancer and Autoimmunity., PMID:35898500
Reduced frequencies of Foxp3+GARP+ regulatory T cells in COPD patients are associated with multi-organ loss of tissue phenotype., PMID:35780120
A Novel Homozygous Missense Variant in the LRRC32 Gene Is Associated With a New Syndrome of Cleft Palate, Progressive Vitreoretinopathy, Growth Retardation, and Developmental Delay., PMID:35656379
Blocking GARP-mediated activation of TGF-β1 did not alter innate or adaptive immune responses to bacterial infection or protein immunization in mice., PMID:34973084
Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism., PMID:34711804
Novel aspects of regulatory T cell dysfunction as a therapeutic target in giant cell arteritis., PMID:34583923
GARP Correlates With Tumor-Infiltrating T-Cells and Predicts the Outcome of Gastric Cancer., PMID:34421887
Functional Th1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity., PMID:34411002
Combined Blockade of GARP:TGF-β1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP+ Blood Vessels in Mouse MC38 Tumors., PMID:34386010
Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP+ regulatory T cells., PMID:34235533
Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32., PMID:34059789
The GARP Domain of the Rod CNG Channel's β1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim., PMID:33637563
Attenuation of GARP expression on regulatory T cells by protein transport inhibitors., PMID:33600819
TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer., PMID:33568351
Expression of Leucine-rich Repeat-containing Protein 32 Following Lymphocyte Stimulation in Patients with Non-IgE-mediated Gastrointestinal Food Allergies., PMID:33380925
GWAS-identified variants to allergic disease and early environmental exposure in Chinese schoolchildren with allergic rhinitis induced by house dust mite., PMID:33274951
Insulin-like growth factor binding protein 7 as a candidate biomarker for systemic sclerosis., PMID:33253093
GARP promotes the proliferation and therapeutic resistance of bone sarcoma cancer cells through the activation of TGF-β., PMID:33203838
Mesenchymal stroma/stem-like cells of GARP knockdown inhibits cell proliferation and invasion of mouse colon cancer cells (MC38) through exosomes., PMID:33155413
Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer., PMID:32917858
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells., PMID:32499651
The Vps52 subunit of the GARP and EARP complexes is a novel Arf6-interacting protein that negatively regulates neurite outgrowth of hippocampal neurons., PMID:32473257
CD52-negative T cells predict acute graft-versus-host disease after an alemtuzumab-based conditioning regimen., PMID:32410220
The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network., PMID:32375042
Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration., PMID:32345721
Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β., PMID:31915300
TGF-β1 - A truly transforming growth factor in fibrosis and immunity., PMID:31879265
Genetic variants of the C11orf30-LRRC32 region are associated with childhood asthma in the Chinese population., PMID:31812328
LRRC33 is a novel binding and potential regulating protein of TGF-β1 function in human acute myeloid leukemia cells., PMID:31600200
Glycoprotein A (GARP) in children who outgrow food allergy., PMID:31477391
VPS53 gene is associated with a new phenotype of complicated hereditary spastic paraparesis., PMID:31418091
GARP as an Immune Regulatory Molecule in the Tumor Microenvironment of Glioblastoma Multiforme., PMID:31357555
EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis., PMID:31158401
Truncation of TGF-β docking receptor GARP is linked to human disease., PMID:31053781
For research use only. Not for human or drug use.
