Catalog No.
PHE27701
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human STAT3 (Met1-Met770).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Signal transducer and activator of transcription 3,APRF,STAT3,Acute-phase response factor
Purification
Purified by antigen affinity column.
Accession
P40763
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
OTUD1 downregulates PD-L1 expression by deubiquitinating STAT3 and promotes the immune response in CcRCC., PMID:40506611
RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes., PMID:40461723
Cdc42 Activation in Anti-nephrin Antibody-Induced Nephropathy., PMID:40459930
Targeted tumor cell-intrinsic CTRP6 biomimetic codelivery synergistically amplifies ferroptosis and immune activation to boost anti-PD-L1 immunotherapy efficacy in lung cancer., PMID:40457410
The role of IL-39 in autoimmune diseases: From general to immunopathogenesis., PMID:40440970
Inhibition of MCP1 (CCL2) Enhances Antitumor Activity of NK Cells Against HCC Cells Under Hypoxia., PMID:40430040
Biological and Clinical Relevance of Genetic Alterations in Peripheral T-cell Lymphomas., PMID:40416001
CD19+IL-10+ regulatory B cells induced by IL-12p35 regulates functional T-cell subsets in patients with immune thrombocytopenia., PMID:40415408
Clostridium difficile as a potent trigger of colorectal carcinogenesis., PMID:40411629
VSIG4 Promotes Tumour-Associated Macrophage M2 Polarization and Immune Escape in Colorectal Cancer via Fatty Acid Oxidation Pathway., PMID:40405491
Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity., PMID:40399681
Autoimmune enteropathy associated with T cell large granular lymphocytic leukemia in a patient with BACH2 mutation: a case report., PMID:40386599
Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells., PMID:40381622
IL-11/IL-11R signal inhibition by 9MW3811 remodels immune tumor microenvironment and enhances anti-tumor efficacy of PD-1 blockade., PMID:40355638
BAP1-mediated ubiquitination inhibition and CAS6/AXL signaling activation in bladder cancer progression., PMID:40330545
Increased protein expression of interleukin-10 and its signalling molecules in colon cancer progression: potential prognostic and therapeutic targets., PMID:40299210
PLOD1 promotes the malignancy of hepatocellular carcinoma by facilitating the NF-κB/IL-6/STAT3-dependent TCA cycle., PMID:40290518
CTLA4 modulates B cell receptor signals to inhibit HBsAb secretion in chronic hepatitis B patients., PMID:40279930
Type I IFN receptor blockade alleviates liver fibrosis through macrophage-derived STAT3 signaling., PMID:40260261
JAK3 A573V and JAK3 M511I mutations in peripheral T-cell lymphoma mediating resistance to anti-PD-1 therapy through the STAT3/PD-L1 pathway., PMID:40199606
A novel IgD-FcδR blocker, IgD-Fc-Ig fusion protein, effectively alleviates abnormal activation of T cells the disease progression in systemic lupus erythematosus., PMID:40194603
APOC1 expressed in macrophages promotes the pulmonary metastasis of colorectal cancer via CCL2/CCL5., PMID:40194454
Unveiling the Role of JAK2/STAT3 signaling in chemoresistance of gynecological cancers: From mechanisms to therapeutic implications., PMID:40187711
Analysis of mutually exclusive expression in cancer cells identifies a previously unknown intergenic regulatory paradigm., PMID:40186387
Circulating miR-485-3p as a biomarker for VEGF-associated therapeutic response to atezolizumab plus bevacizumab in hepatocellular carcinoma., PMID:40180668
Functional insights of an uncommon hypomorphic variant in IL2RG as a monogenic cause of CVID-like disease with antibody deficiency and T CD4 lymphopenia., PMID:40170851
The effects of interleukin-35 and interleukin-10 on pulmonary inflammation and fibrosis in a bleomycin-induced systemic sclerosis mouse model., PMID:40153333
Brusatol ameliorates intestinal mucosal injury in ulcerative colitis via activating IL-22/STAT3 pathway., PMID:40101416
Fibrinogen-like 2 in tumor-associated macrophage-derived extracellular vesicles shapes an immunosuppressive microenvironment in colorectal liver metastases by promoting tumor stemness and neutrophil extracellular traps formation., PMID:40097065
Dynamic responses to rejection in the transplanted human heart revealed through spatial transcriptomics., PMID:40093136
ROS-dependent SOCS3 upregulation disrupts regulatory T cell stability during autoimmune disease development., PMID:40090133
BRD7 Inhibited Immune Escape in Nasopharyngeal Carcinoma via Inhibiting PD-L1 Expression., PMID:40083706
Hyper IgE Syndrome: Bridging the Gap Between Immunodeficiency, Atopy, and Allergic Diseases., PMID:40082265
Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway., PMID:40049088
Jieyu Guben decoction alleviates combined allergic rhinitis and asthma syndrome by balancing Th17/Treg expression and restoring PPARD., PMID:40031093
BTK inhibitors enhance NKG2D ligand expression by regulating IL-10/STAT3 pathway in activated non-GCB diffuse large B-cell lymphoma cells., PMID:40029697
TLR-4Ab and IFNγAb with exogenous IL-10 treated LPS induced mice shown differential inflammatory response upon RANKL-M-CSF stimulation in resident bone marrow cells., PMID:40023455
Gastric-type endocervical adenocarcinoma, superficial myofibroblastoma, sex cord-stromal tumors, and HSIL in Peutz-Jeghers syndrome: a rare case report, genetic characterization, and review of literature., PMID:40018404
Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn's disease., PMID:39978335
Potential Modulatory Effects of Hesperidin on the JAK/STAT Pathway in Mesangial Proliferative Glomerulonephritis., PMID:39928525
Characterisation of the antinociceptive effect of baricitinib in the collagen antibody-induced arthritis mouse model., PMID:39924372
Molecular basis for the disease-modifying effects of belimumab in systemic lupus erythematosus and molecular predictors of early response: blood transcriptome analysis implicates the innate immunity and DNA damage response pathways., PMID:39919899
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy., PMID:39893129
Deletion of PTP4A3 phosphatase in high-grade serous ovarian cancer cells decreases tumorigenicity and produces marked changes in intracellular signaling pathways and cytokine release., PMID:39892999
Borrelia burgdorferi sensu lato inhibits CIITA transcription through pSTAT3 activation and enhanced SOCS1 and SOCS3 expression leading to limited IFN-γ production., PMID:39879745
Practical management of adverse events in patients receiving tarlatamab, a delta-like ligand 3-targeted bispecific T-cell engager immunotherapy, for previously treated small cell lung cancer., PMID:39876075
Genomic profiling at a single center cracks the code in inborn errors of immunity., PMID:39873967
IL-21 signaling promotes IgM+ B cell proliferation and antibody production via JAK/STAT3 and AKT pathways in early vertebrates., PMID:39870186
A biodegradable magnesium alloy promotes subperiosteal osteogenesis via interleukin-10-dependent macrophage immunomodulation., PMID:39862617
The combination treatment of RC48 and STAT3 inhibitor acts as a promising therapeutic strategy for basal bladder cancer., PMID:39840049
For research use only. Not for human or drug use.
