Catalog No.
YMD38501
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Val146-Glu343
Predicted molecular weight
24.77 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35329
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
B-cell receptor CD22, Siglec-2, T-cell surface antigen Leu-14, B-lymphocyte cell adhesion molecule, CD22, Siglec2, Lyb-8, Sialic acid-binding Ig-like lectin 2, Cd22, BL-CAM
Efficacy and safety of a novel CD19, CD22 dual-targeted fully human loop bi-CAR-T for the treatment of relapsed/refractory B cell non-Hodgkin lymphoma., PMID:40474279
Recent advances in monoclonal antibody development for treatment of B-cell acute lymphoblastic leukemia., PMID:40455243
Differentiation-dependent EBF1 Activity Determines CD22 Transcription and Leukemia Sensitivity to Inotuzumab Ozogamicin., PMID:40435412
Efficacy and safety of CD19 combined with CD22 or CD20 chimeric antigen receptor T-cell therapy for hematological malignancies., PMID:40433368
Phenotypic Profile of Waldenström Macroglobulinaemia B-Cells: Establishment of a Diagnosis Scoring System and Clinico-Biological Correlations., PMID:40407640
Optimal Structural Designs of Trispecific Antibodies to Enhance Therapeutic Efficacy in Solid Tumors and Hematological Malignancies., PMID:40402462
Emerging roles of ADAM6 and PRSS1 as novel diagnostic/prognostic biomarkers for acute lymphoblastic and myeloid leukemia in adults., PMID:40382561
Analysis of CD22 cis-ligands using a synthetic sialoside binding to CD22 with ultra-high affinity., PMID:40381245
Identification of Hub Genes and Pathways in Preinfusion Chimeric Antigen Receptor (CAR) T-cell Products Associated With Cytokine Release Syndrome., PMID:40370902
The evolving therapeutic revolution in adult acute lymphoblastic leukemia., PMID:40323723
Optimization of hypo-alloimmunogenic multispecific CAR-T and SARS-CoV-2-specific T cells for off-the-shelf adoptive cell therapy., PMID:40321414
CD22 CAR-T cells secreting CD19 T-cell engagers for improved control of B-cell acute lymphoblastic leukemia progression., PMID:40306957
Regulatory B cells attenuate sepsis-associated pancreatic injury by regulating T cell homeostasis., PMID:40281196
Identifying Modifiers of CAR T-Cell Therapeutic Efficacy and Safety: A Systematic Review and Individual Patient Data Meta-Analysis., PMID:40280037
IKAROS levels are associated with antigen escape in CD19- and CD22-targeted therapies for B-cell malignancies., PMID:40268897
CD58 could be a leukemic marker in patients with relapsed/refractory B-cell acute lymphoblastic leukemia after multiline therapies., PMID:40253622
CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy., PMID:40246579
CD22 TCR-engineered T cells exert antileukemia cytotoxicity without causing inflammatory responses., PMID:40203088
Efficacy and safety comparison of CAR-T and blinatumomab immunotherapy as bridge-to-transplant strategies in relapsed/refractory B cell acute lymphoblastic leukemia., PMID:40181350
[Construction of a camel-derived natural phage nanobody display library and screening of anti-CD22 nanobodies]., PMID:40145457
Gold Nanoparticles Synthesized with Triple-Negative Breast Cancer Cell Lysate Enhance Antitumoral Immunity: A Novel Synthesis Method., PMID:40143109
Novel Phenotypical and Biochemical Findings in Mucolipidosis Type II., PMID:40141052
Regulatory and disruptive variants in the CLCN2 gene are associated with modified skin color pattern phenotypes in the corn snake., PMID:40140900
INO-CD22: A multicenter, real-world study of inotuzumab ozogamicin safety and effectiveness in adult patients with relapsed/refractory acute lymphoblastic leukemia., PMID:40120068
Be cautious to adopt a second CAR T-cell infusion after failure of CD19/CD22 cocktail CAR T-cell therapy in relapsed/refractory B-NHL., PMID:40119886
JAK Inhibitors and B Cell Function: A Comparative Study of Their Impact on Plasma Cell Differentiation, Cytokine Production, and Naïve B Cell Activation., PMID:40098342
Talicabtagene autoleucel for relapsed or refractory B-cell malignancies: results from an open-label, multicentre, phase 1/2 study., PMID:40090352
Immunophenotype of CAR T cells and apheresis products predicts response in CD22 CAR T cell trial for B cell acute lymphoblastic leukemia., PMID:40087865
Inotuzumab Ozogamicin as a Bridge to Stem Cell Transplantation in Relapsed Pediatric BCP-ALL After Tisagenlecleucel: A Case Series., PMID:40085546
Restoration of LAT activity improves CAR T cell sensitivity and persistence in response to antigen-low acute lymphoblastic leukemia., PMID:40068599
ABO-A antibody induction in mice is T cell-dependent, estrogen-independent, and modulated by CD22., PMID:40057198
Insights into the transcriptional regulation of CD22 in B cell chronic lymphocytic leukemia., PMID:40054694
MYC-r with a non-IG partner concurrently with a cryptic t(12;21) in B-lymphoblastic leukemia: A case and prognostic significance., PMID:39983666
A Meta-analysis on Effects of Chimeric Antigen Receptor T-cell Therapy in Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia., PMID:39956997
CD22 exacerbates brain injury in subarachnoid hemorrhage by inhibiting microglial phagocytic function., PMID:39954002
Licochalcone A prevents cognitive decline in a lipopolysaccharide-induced neuroinflammation mice model., PMID:39930360
IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells., PMID:39919198
HLA-DMB correlates with antitumor immunity and an improved prognosis in endometrial carcinoma tumors., PMID:39917362
CD22 modulation alleviates amyloid β-induced neuroinflammation., PMID:39910617
CAR T-cell therapy landscape in pediatric, adolescent and young adult oncology - A comprehensive analysis of clinical trials., PMID:39900318
Tumor-specific cytosol-penetrating antibodies for antigen- and TME-dependent intracellular cargo delivery., PMID:39895690
FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis., PMID:39871339
Cryptic to conventional cytogenetics: Philadelphia-like ALL presenting with hypereosinophilia., PMID:39842907
Effect of high-fat diet on IgA+ cells and BAFF/APRIL in small intestinal villous lamina propria of mice., PMID:39842230
Systematic review of amyloid-beta clearance proteins from the brain to the periphery: implications for Alzheimer's disease diagnosis and therapeutic targets., PMID:39820231
Head-to-Head Comparison of Aptamer- and Antibody-Based Proteomic Platforms in Human Cerebrospinal Fluid Samples from a Real-World Memory Clinic Cohort., PMID:39796148
Characterizing the ideal patient for treatment with inotuzumab ozogamicin for relapsed/refractory acute lymphoblastic leukemia: a systematic literature review., PMID:39778191
Effects of an Initial Anti-CD19 CAR T-cell Therapy on Subsequent Anti-CD22 CAR T-cell Manufacturing and Clinical Outcomes in Patients with Relapsed/Refractory LBCL., PMID:39775812
Cord blood platelet-rich plasma: proteomics analysis for ophthalmic applications., PMID:39754030
Case report: A novel third-generation anti-CD19/CD22 CAR T-cells combined with auto-HSCT for relapsed Burkitt lymphoma., PMID:39717765
For research use only. Not for human or drug use.
