Catalog No.
YMJ04001
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Thr26-Gly239
Predicted molecular weight
25.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8VE98
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cd276, B7 homolog 3, CD276 antigen, CD276, B7-H3, B7h3, Costimulatory molecule
PARP inhibitors accumulate B7-H3 on fibroblasts via blocking autophagic flux to potentiate immune evasion in ovarian cancer., PMID:40497528
Single-cell and clonal analysis of AL amyloidosis plasma cells and their bone marrow microenvironment., PMID:40493887
B7-H3 and c-MET in advanced prostate cancer: exploring possibilities of novel bi-specific drug development., PMID:40490821
Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition., PMID:40452017
Prognostic Value of B7-H3 and a Novel Scoring System in Localized Renal Cell Carcinoma., PMID:40428825
B7-H3 and CSPG4 co-targeting as Pan-CAR-T cell treatment of triple-negative breast cancer., PMID:40425233
HIV status alters immune cell infiltration and activation profile in women with breast cancer., PMID:40393975
MCSP+ metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization., PMID:40379833
Identification of Hub Genes and Pathways in Preinfusion Chimeric Antigen Receptor (CAR) T-cell Products Associated With Cytokine Release Syndrome., PMID:40370902
A comprehensive analysis identified an autophagy-related risk model for predicting recurrence and immunotherapy response in stage I lung adenocarcinoma., PMID:40330698
Biomarkers of response to antibody-drug conjugates (TROP2 and nectin-4) and the immune microenvironment (NKG7, PD-L1, and B7-H3) in penile squamous cell carcinoma., PMID:40327767
PKM2 modulates chemotherapy sensitivity by regulating autophagy and predicts the prognosis and immunity in pancancer., PMID:40287473
High B7-H3 protein expression in Medulloblastoma is associated with metastasis and unfavorable patient outcomes., PMID:40269882
Prognostic Significance of B7H3 Expression in Solid Tumors: A Systematic Review and Meta-Analysis., PMID:40243697
Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity., PMID:40229277
Targeting B7-H3 inhibition-induced activation of fatty acid synthesis boosts anti-B7-H3 immunotherapy in triple-negative breast cancer., PMID:40221152
B7H3 in Gastrointestinal Tumors: Role in Immune Modulation and Cancer Progression: A Review of the Literature., PMID:40214484
Do we need B7-H3 immunohistochemistry for the inclusion of children with high-grade central nervous system tumors in clinical trials targeting B7-H3?, PMID:40207575
Molecular Imaging of B7-H3-Targeting Bispecific T Cell-Engaging Antibody MGD009 in Glioblastoma Models., PMID:40183579
Potential value of B7-H3 in sepsis diagnosis and prognosis: A Mendelian randomization study., PMID:40177762
Targeting CD276: a promising strategy for CAR-NK cell immunotherapy in human oral tongue squamous cell carcinoma., PMID:40169956
Establishing a Prognostic Model Correlates to Inflammatory Response Pathways for Prostate Cancer via Multiomic Analysis of Lactylation-Related Genes., PMID:40161494
Novel blood-based proteomic signatures across multiple neurodegenerative diseases., PMID:40145305
Microglia-Derived Brain Macrophages Associate with Glioblastoma Stem Cells: A Potential Mechanism for Tumor Progression Revealed by AI-Assisted Analysis., PMID:40136662
Targeting B7-H3 in solid tumors: Development and evaluation of novel CAR-T Cell therapy., PMID:40121824
Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules., PMID:40109742
[Expression level and application analysis of soluble costimulatory molecule B7-H3 in the serum of patients with colorectal cancer]., PMID:40107790
Involvement of the disulfidptosis-related immune checkpoint gene, CD276, in glioblastoma malignant phenotype and poor prognosis., PMID:40079417
Co-expression of B7-H3 and LAG3 represents cytotoxicity of CD4+ T cells in humans., PMID:40070836
B7-H3-mediated deubiquitination stabilizing CYP1B1 expression promotes chemotherapy resistance in colorectal cancer., PMID:40057208
Gene Expression Signatures of Porcine Bone Marrow-Derived Antigen-Presenting Cells Infected with Classical Swine Fever Virus., PMID:40006915
Identification of the B7-H3 Interaction Partners Using a Proximity Labeling Strategy., PMID:40004194
Histone lactylation-driven B7-H3 expression promotes tumor immune evasion., PMID:39990209
Tumor Microenvironment-Responsive Nano-Immunomodulators for Enhancing Chimeric Antigen Receptor-T Cell Therapy in Lung Cancer., PMID:39988897
CD276 as a critical independent biomarker and immune checkpoint inhibitor target in epithelioid mesothelioma-TCGA study., PMID:39975728
Prevalence and Clinical Association of CD276 (B7-H3) Expression in Pleural Mesothelioma: Results From the European Thoracic Platform Mesoscape Project., PMID:39938010
The AURKA inhibitor alters the immune microenvironment and enhances targeting B7-H3 immunotherapy in glioblastoma., PMID:39928563
UBE2T/CDC42/CD276 signaling axis mediates brain metastasis of triple-negative breast cancer via lysosomal autophagy., PMID:39915000
B7-H3-liquid biopsy for the characterization and monitoring of the dynamic biology of prostate cancer., PMID:39914189
Tumor vascular normalization by B7-H3 blockade augments T lymphocyte-mediated antitumor immunity., PMID:39892447
Novel B7-H3 CAR T cells show potent antitumor effects in glioblastoma: a preclinical study., PMID:39863300
B7-H3 CAR-T cell therapy combined with irradiation is effective in targeting bulk and radiation-resistant chordoma cancer cells., PMID:39848690
Identification and characterization of CD83 and CD276 as markers of dendritic cells in olive flounder (Paralichthys olivaceus)., PMID:39848419
A humanized anti-b7h3×4-1BB bispecific antibody exerts potent antitumour effects through the activation of innate and adaptive immunity., PMID:39847994
A whole-body imaging technique for tumor-specific diagnostics and screening of B7H3-targeted therapies., PMID:39847434
Lineage-dependence of the neuroblastoma surfaceome defines tumor cell state-dependent and independent immunotherapeutic targets., PMID:39825754
An immunohistochemical and molecular genetic study of 60 colorectal carcinoma brain metastases in pursuit of predictive biomarkers for cancer therapy., PMID:39824298
Unraveling the dynamics of B7-H3-targeting therapeutic antibodies in cancer through PET imaging and antibody pharmacokinetics., PMID:39814321
Engineered T cells secreting αB7-H3-αCD3 bispecific engagers for enhanced anti-tumor activity against B7-H3 positive multiple myeloma: a novel therapeutic approach., PMID:39806405
TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids., PMID:39785827
For research use only. Not for human or drug use.
