Catalog No.
YMB10201
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Glu47-Gln258
Predicted molecular weight
26.21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9JHJ8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD275, LICOS, ICOS ligand, Icoslg, B7 homolog 2, B7-H2, B7h2, B7rp1, B7-like protein Gl50, B7RP-1, B7-related protein 1, Icosl
miR-155 impairs ICOSL and MHC-I expression in DLBCL lymphomas., PMID:40249785
Aire attenuate collagen-induced arthritis by suppressing T follicular helper cells through ICOSL., PMID:39626537
Role of Balanced Involvement of the ICOS/ICOSL/Osteopontin Network in Cutaneous Wound Healing., PMID:39596455
CD34+ and CD34- MM cells show different immune-checkpoint molecule expression profiles: high expression of CD112 and CD137 ligand on CD34+ MM cells., PMID:39531203
ICOS-ICOSL pathway enhances NKT-like cell antiviral function in pregnant women with COVID-19., PMID:39113896
ICOSLG acts as an oncogene to promote glycolysis, proliferation, migration, and invasion in gastric cancer cells., PMID:38081339
Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis., PMID:38077334
Epstein-Barr virus-encoded EBNA2 downregulates ICOSL by inducing miR-24 in B-cell lymphoma., PMID:37847858
Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair., PMID:34925367
The role of ICOS in allergic disease: Positive or Negative?, PMID:34922247
Upregulation of type 1 conventional dendritic cells implicates antigen cross-presentation in multisystem inflammatory syndrome., PMID:34688775
The Positive and Negative Immunoregulatory Role of B7 Family: Promising Novel Targets in Gastric Cancer Treatment., PMID:34639059
Mifepristone inhibited the expression of B7-H2, B7-H3, B7-H4 and PD-L2 in adenomyosis., PMID:34289871
Activated neutrophils polarize protumorigenic interleukin-17A-producing T helper subsets through TNF-α-B7-H2-dependent pathway in human gastric cancer., PMID:34185422
ICOSL in host defense at epithelial barriers: lessons from ICOSLG deficiency., PMID:33756276
Mesenchymal stem cells regulate type 2 innate lymphoid cells via regulatory T cells through ICOS-ICOSL interaction., PMID:33662168
Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion., PMID:33459589
Osteopontin binds ICOSL promoting tumor metastasis., PMID:33106594
Dysregulated NF-κB-Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma., PMID:33051240
Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies., PMID:33033255
Generation of pancreatic β cells from CD177+ anterior definitive endoderm., PMID:32341565
Disruption of the Notch pathway aggravates airway inflammation by inhibiting regulatory T cell differentiation via regulation of plasmacytoid dendritic cells., PMID:32185817
Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity., PMID:32142650
Human inflammatory dendritic cells in malignant pleural effusions induce Th1 cell differentiation., PMID:32052078
Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts., PMID:32049348
The ICOSL Expression Predicts Better Prognosis for Nasopharyngeal Carcinoma via Enhancing Oncoimmunity., PMID:31998801
High-Content Immunophenotyping and Hierarchical Clustering Reveal Sources of Heterogeneity and New Surface Markers of Human Blood Monocyte Subsets., PMID:31887780
[Loss of human ICOSLG results in combined immunodeficiency]., PMID:31532372
Unbalanced expression of membrane-bound and soluble inducible costimulator and programmed cell death 1 in patients with myasthenia gravis., PMID:31374257
Antigen-specific CD4+ CD25+ T cells induced by locally expressed ICOS-Ig: the role of Foxp3, Perforin, Granzyme B and IL-10 - an experimental study., PMID:31225919
ICOS/ICOSL upregulation mediates inflammatory response and endothelial dysfunction in type 2 diabetes mellitus., PMID:30575933
Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration., PMID:30463956
Acute Myeloid Leukemia Cells Express ICOS Ligand to Promote the Expansion of Regulatory T Cells., PMID:30319662
ICOS-L as a Potential Therapeutic Target for Cancer Immunotherapy., PMID:29879883
Polymorphisms in the ICOS/CD28-ICOSL pathway are related to capecitabine-based chemotherapy response in advanced colon cancer patients., PMID:29505962
FOXP3, ICOS and ICOSL gene polymorphisms in systemic sclerosis: FOXP3 rs2294020 is associated with disease progression in a female Italian population., PMID:29030005
ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses., PMID:28814605
MiR21 sensitized B-lymphoma cells to ABT-199 via ICOS/ICOSL-mediated interaction of Treg cells with endothelial cells., PMID:28637496
Antigen-Presenting Human γδ T Cells Promote Intestinal CD4+ T Cell Expression of IL-22 and Mucosal Release of Calprotectin., PMID:28330898
ICOSL expression in human bone marrow-derived mesenchymal stem cells promotes induction of regulatory T cells., PMID:28290526
Smoking reduces circulating CD26hiCD161hi MAIT cells in healthy individuals and patients with multiple sclerosis., PMID:28179539
ICOS-Ligand Triggering Impairs Osteoclast Differentiation and Function In Vitro and In Vivo., PMID:27798154
Activation and selective IL-17 response of human Vγ9Vδ2 T lymphocytes by TLR-activated plasmacytoid dendritic cells., PMID:27590513
B cells are required for sunlight protection of mice from a CNS-targeted autoimmune attack., PMID:27289166
Autoantibody-Mediated Pulmonary Alveolar Proteinosis in Rasgrp1-Deficient Mice., PMID:27279372
Follicular B Lymphomas Generate Regulatory T Cells via the ICOS/ICOSL Pathway and Are Susceptible to Treatment by Anti-ICOS/ICOSL Therapy., PMID:27246829
ICOS Promotes the Function of CD4+ Effector T Cells during Anti-OX40-Mediated Tumor Rejection., PMID:27197182
CD275-Independent IL-17-Producing T Follicular Helper-like Cells in Lymphopenic Autoimmune-Prone Mice., PMID:27183569
Altered immune parameters correlate with infection-related hospitalizations in children with Down syndrome., PMID:27166175
Development of a novel monoclonal antibody to human inducible co-stimulator ligand (ICOSL): Biological characteristics and application for enzyme-linked immunosorbent assay., PMID:27138044
For research use only. Not for human or drug use.
