Anti-SNCA Polyclonal Antibody

Catalog No.

PHE22001

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SNCA (Met1-Ala140).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Alpha-synuclein,PARK1,Non-A4 component of amyloid precursor,NACP,Non-A beta component of AD amyloid,SNCA

Purification

Purified by antigen affinity column.

Accession

P37840

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Lewy-MSA hybrid fold drives distinct neuronal α-synuclein pathology., PMID:40523906

Generation of iPSC lines with tagged α-synuclein for visualization of endogenous protein in human cellular models of neurodegenerative disorders., PMID:40456614

A fragment of Calpain-1 cleaved α-Synuclein quantified in serum is upregulated in patients with Parkinson's disease., PMID:40204767

Distinct subcellular localization of tau and alpha-synuclein in lewy body disease., PMID:39838428

N-terminus α-synuclein detection reveals new and more diverse aggregate morphologies in multiple system atrophy and Parkinson's disease., PMID:39726015

Responsiveness of anti-VEGF treatment for polypoidal choroidal vasculopathy based on aqueous humour proteomics: A preliminary study., PMID:39420792

An immunoassay for the quantification of phosphorylated α-synuclein at serine 129 in human cerebrospinal fluid., PMID:39404180

An Inducible Luminescent System to Explore Parkinson's Disease-Associated Genes., PMID:39273438

Ultrasensitive detection of aggregated α-synuclein using quiescent seed amplification assay for the diagnosis of Parkinson's disease., PMID:39049095

Follow-Up Study of 17-β Estradiol, Prolactin and Progesterone with the Kinetics and Prevalence of T. gondii Infection in Pregnant Women., PMID:38921012

A multiverse of α-synuclein: investigation of prion strain properties with carboxyl-terminal truncation specific antibodies in animal models., PMID:38858742

Computer-Based Evaluation of α-Synuclein Pathology in Multiple System Atrophy as a Novel Tool to Recognize Disease Subtypes., PMID:38852813

Biphenotypic Cells and α-Synuclein Accumulation in Enteric Neurons of Leucine-Rich Repeat Kinase 2 Knockout Mice., PMID:38849592

SNCA and TPPP transcripts increase in oligodendroglial cytoplasmic inclusions in multiple system atrophy., PMID:38839023

Solubility of α-synuclein species in the L62 mouse model of synucleinopathy., PMID:38486089

Protease-Sensitive and -Resistant Forms of Human and Murine Alpha-Synucleins in Distinct Brain Regions of Transgenic Mice (M83) Expressing the Human Mutated A53T Protein., PMID:38136658

Neuronal SNCA transcription during Lewy body formation., PMID:37996943

Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain., PMID:37485772

Specific Detection of Physiological S129 Phosphorylated α-Synuclein in Tissue Using Proximity Ligation Assay., PMID:36847016

Interplay between APP and glypican-1 processing and α-synuclein aggregation in undifferentiated and differentiated human neural progenitor cells., PMID:36790131

Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction., PMID:36719240

Who Ever Said It Would Be Easy? Reflecting on Two Clinical Trials Targeting α-Synuclein., PMID:36645106

Dynamin-like Protein 1 (DNML1) as a Molecular Target for Antibody-Based Immunotherapy to Treat Glaucoma., PMID:36362420

MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis., PMID:36175420

Cellular Therapy Using Epitope-Imprinted Composite Nanoparticles to Remove α-Synuclein from an In Vitro Model., PMID:36010659

Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation., PMID:36009004

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity., PMID:35353605

Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson's Disease and Multiple System Atrophy., PMID:35269528

Characterization of a Novel Monoclonal Antibody for Serine-129 Phosphorylated α-Synuclein: A Potential Application for Clinical and Basic Research., PMID:35250825

Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain., PMID:35012605

Sensitive electrochemical recognition of α-synuclein protein in human plasma samples using bioconjugated gold nanoparticles: An innovative immuno-platform to assist in the early stage identification of Parkinson's disease by biosensor technology., PMID:34985150

1-Indanone and 1,3-indandione Derivatives as Ligands for Misfolded α-Synuclein Aggregates., PMID:34704363

LC-MS/MS assay for the investigation of acetylated Alpha-synuclein in serum from postmortem Alzheimer's disease pathology., PMID:34479181

Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies., PMID:34454615

Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects., PMID:34454586

A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies., PMID:34309760

Visualization of early oligomeric α-synuclein pathology and its impact on the dopaminergic system in the (Thy-1)-h[A30P]α-syn transgenic mouse model., PMID:34292621

The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy., PMID:34115198

Cerebrospinal fluid and plasma distribution of anti-α-synuclein IgMs and IgGs in multiple system atrophy and Parkinson's disease., PMID:34020303

HIV-1 Vpr protein impairs lysosome clearance causing SNCA/alpha-synuclein accumulation in neurons., PMID:33890542

In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC., PMID:33837116

Dose-related biphasic effect of the Parkinson's disease neurotoxin MPTP, on the spread, accumulation, and toxicity of α-synuclein., PMID:33549656

In vivo distribution of α-synuclein in multiple tissues and biofluids in Parkinson disease., PMID:32747521

Downregulation of α-Synuclein Protein Levels by an Intracellular Single-Chain Antibody., PMID:32176654

Engineering a Proximity-Directed O-GlcNAc Transferase for Selective Protein O-GlcNAcylation in Cells., PMID:32119511

Alpha-synuclein fragments trigger distinct aggregation pathways., PMID:32015326

Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease., PMID:31837422

Gold-nanourchin seeded single-walled carbon nanotube on voltammetry sensor for diagnosing neurogenerative Parkinson's disease., PMID:31761041

Electrochemical biosensors for the detection and study of α-synuclein related to Parkinson's disease - A review., PMID:31627816

Stabilization of α-synuclein oligomers using formaldehyde., PMID:31603909

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