Catalog No.
PHE20001
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SREBF1/SREBP1 (Glu30-Leu490).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Sterol regulatory element-binding protein 1,SREBF1,BHLHD1,Transcription factor SREBF1,Sterol regulatory element-binding transcription factor 1,Class D basic helix-loop-helix protein 1,bHLHd1,SREBP-1,SREBP1
Purification
Purified by antigen affinity column.
Accession
P36956
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Increasing membrane polyunsaturated fatty acids sensitizes non-small cell lung cancer to anti-PD-1/PD-L1 immunotherapy., PMID:39245263
Selective PI3Kδ inhibitor TYM-3-98 suppresses AKT/mTOR/SREBP1-mediated lipogenesis and promotes ferroptosis in KRAS-mutant colorectal cancer., PMID:38956060
Fumarate Hydratase Enhances the Therapeutic Effect of PD-1 Antibody in Colorectal Cancer by Regulating PCSK9., PMID:38398104
A proline metabolism selection system and its application to the engineering of lipid biosynthesis in Chinese hamster ovary cells., PMID:34386349
Clozapine Worsens Glucose Intolerance, Nonalcoholic Fatty Liver Disease, Kidney Damage, and Retinal Injury and Increases Renal Reactive Oxygen Species Production and Chromium Loss in Obese Mice., PMID:34206460
Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis., PMID:32078435
Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production., PMID:31805379
Oleic acid in the absence of a PPARγ agonist increases adipogenic gene expression in bovine muscle satellite cells1., PMID:31424542
Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease., PMID:28902428
Kupffer cells activation promoted binge drinking-induced fatty liver by activating lipolysis in white adipose tissues., PMID:28882574
Stress-induced release of Oct-1 from the nuclear envelope is mediated by JNK phosphorylation of lamin B1., PMID:28542436
Effects of Viola mandshurica on Atherosclerosis and Hepatic Steatosis in ApoE[Formula: see text] via the AMPK Pathway., PMID:28514904
[Regulation of SIRT1 by SREBP-1 in Adipogenic Differentiation of Mesenchymal Stem Cells]., PMID:27151035
CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways., PMID:26282231
Fluoxetine suppresses AMP-activated protein kinase signaling pathway to promote hepatic lipid accumulation in primary mouse hepatocytes., PMID:25102273
The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis., PMID:24755648
Prolyl-isomerase Pin1 impairs trastuzumab sensitivity by up-regulating fatty acid synthase expression., PMID:24596388
Inhibition of SREBP1 sensitizes cells to death ligands., PMID:21406729
PTEN ameliorates high glucose-induced lipid deposits through regulating SREBP-1/FASN/ACC pathway in renal proximal tubular cells., PMID:21320485
Human resistin stimulates hepatic overproduction of atherogenic ApoB-containing lipoprotein particles by enhancing ApoB stability and impairing intracellular insulin signaling., PMID:21293001
Androgen receptor survival signaling is blocked by anti-beta2-microglobulin monoclonal antibody via a MAPK/lipogenic pathway in human prostate cancer cells., PMID:20071336
Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism., PMID:19826053
Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver., PMID:18413311
RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet., PMID:17188681
Saturated fat-induced changes in Sf 60-400 particle composition reduces uptake of LDL by HepG2 cells., PMID:16278492
Hyperphosphorylation regulates the activity of SREBP1 during mitosis., PMID:16081540
Post-transcriptional regulation of sterol regulatory element-binding protein-1 by ethanol induces class I alcohol dehydrogenase in rat liver., PMID:15123720
Importin beta1 mediates the glucose-stimulated nuclear import of pancreatic and duodenal homeobox-1 in pancreatic islet beta-cells (MIN6)., PMID:14632628
Lipogenic enzymes fatty acid synthase and acetyl-coenzyme A carboxylase are coexpressed with sterol regulatory element binding protein and Ki-67 in fetal tissues., PMID:11000330
Neuronal localization of sterol regulatory element binding protein-1 in the rodent and primate brain: a light and electron microscopic immunocytochemical study., PMID:10771346
Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites., PMID:10759542
Effects of fibrillar C-terminal fragment of cleaved alpha1-antitrypsin on cholesterol homeostasis in HepG2 cells., PMID:9918920
Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase., PMID:9478955
Upstream stimulatory factor binding to the E-box at -65 is required for insulin regulation of the fatty acid synthase promoter., PMID:9334210
Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol., PMID:9380697
Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein., PMID:9242699
For research use only. Not for human or drug use.
