Endoplasmic Reticulum Stress in Acute Myeloid Leukemia: Pathogenesis, Prognostic Implications, and Therapeutic Strategies., PMID:40243748
D-M159 Synergistically Induces Apoptosis in HeLa Cells Through Endoplasmic Reticulum Stress and Mitochondrial Dysfunction., PMID:40243937
Parkinson's Disease: The Neurodegenerative Enigma Under the "Undercurrent" of Endoplasmic Reticulum Stress., PMID:40244210
The Effect of Electroconvulsive Therapy on Hippocampal Endoplasmic Reticulum Stress in a Rat Model of Depression., PMID:40245333
Gliadin-dependent UPR induction directly triggers the expression of TG2 and pro-inflammatory cytokines, dysregulates intestinal permeability, and reduces CFTR expression in intestinal epithelial cells of celiac disease patients., PMID:40247380
Spring viraemia of carp virus modulates the time-dependent unfolded protein response to facilitate viral replication., PMID:40248709
APEX1 attenuates ERS-induced paraptosis by inhibiting the P53 pathway in LECs., PMID:40254119
Activation of ATF6 Signaling Confers Long-Term Beneficial Effects in Young and Aged Mice After Permanent Stroke., PMID:40259100
Glucose sensing and the unfolded protein response., PMID:40272086
Quercetin alleviates cerebral ischemia and reperfusion injury in hyperglycemic animals by reducing endoplasmic reticulum stress through activating SIRT1., PMID:40273147
The Role of ER Stress and the Unfolded Protein Response in Cancer., PMID:40280715
Moderate exercise relieves heart failure-induced skeletal muscle atrophy through the inhibition of MAPK/SOCS3 signaling., PMID:40286786
Endurance Training Alleviates Metabolic-Associated Fatty-Liver Disease (MAFLD)-Related Testicular Impairments via Endoplasmic Reticulum Stress Regulation., PMID:40313012
Cigarette smoke induces endoplasmic reticulum stress-associated mucus hypersecretion via orosomucoid 1-like protein 3 in airway epithelia., PMID:40317248
Modulation in NF-κB-p65/NLRP3, TXNIP-mediated signaling using an ethanolic fruit extract of Withania coagulans mitigates silica-induced pulmonary fibrosis in rats., PMID:40318702
Altered lung inflammation and expression of endoplasmic reticulum stress markers in male mice aged-asthma model., PMID:40319712
Endoplasmic Reticulum Stress as a Regulator of High Glucose-Induced Epithelial-Mesenchymal Transition in Human Lens Epithelial Cells., PMID:40322907
p.Phe508del-CFTR Trafficking: A Protein Quality Control Perspective Through UPR, UPS, and Autophagy., PMID:40332143
Impaired CAMK4 Activity Limits Atherosclerosis and Reprograms Myelopoiesis., PMID:40336480
ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways., PMID:40347515
Empagliflozin attenuates DOX-induced cardiotoxicity by inhibiting RIPK1-mediated endoplasmic reticulum stress and autophagy., PMID:40350043
[Effects of total flavonoids of Dracocephalum moldavica on apoptosis of H9c2 cells induced by OGD/R injury and endoplasmic reticulum stress]., PMID:40350915
Endoplasmic reticulum stress regulates swainsonine-induced the autophagy in renal tubular epithelial cells through UPR signaling pathway., PMID:40354703
QRICH1 regulates ATF6 transcription to affect pathological cardiac hypertrophy progression., PMID:40355839
Therapeutic application of nano-encapsulated pomegranate peel extract attenuated DSS-induced colitis: Antioxidant and anti-inflammatory role and reduction of exaggerated response of endoplasmic reticulum stress., PMID:40359212
ER stress and/or ER-phagy in drug resistance? Three coincidences are proof., PMID:40361118
BiP, GRP94, calreticulin and calnexin contribute to development of the notochord in medaka fish., PMID:40368802
Nephroprotective effects of hesperidin on ifosfamide-induced acute nephrotoxicity in rats: Role of NF-κB/TNF-α/ IL-1β, p53/caspase-3/Bax/Bcl-2, and ATF6/IRE1/PERK/GRP78 signaling pathways., PMID:40373990
SEC24D depletion induces osteogenic differentiation deficiency by inactivating the ATF6/TGF-β/Runx2 regulatory loop., PMID:40374976
Type 2 calreticulin mutations activate ATF6 to promote BCL-xL-mediated survival in myeloproliferative neoplasms., PMID:40403318
The impact of copper-induced oxidative damage on the endoplasmic reticulum quality control system in broiler kidneys., PMID:40404888
The PERK-eIF2α pathway of the unfolded protein response inhibits white spot syndrome virus infection by attenuating global protein translation., PMID:40409696
Heat shock induces alternative polyadenylation through dynamic DNA methylation and chromatin looping., PMID:40412548
Docosahexaenoic Acid Attenuates Endoplasmic Reticulum Stress-Induced Neuron Apoptosis by Targeting Presenilin 2., PMID:40415367
RNA-seq revealed the effects of heat stress on different brain regions of Leiocassis longirostris., PMID:40432926
Fufang zhenzhu tiaozhi capsule alleviates hypothalamic endoplasmic reticulum stress and leptin resistance through autophagy modulation in DIO rats., PMID:40436122
Lycopene alleviates splenic injury in grass carp (Ctenopharyngodon idella) caused by endoplasmic reticulum stress-autophagy axis induced by sulfamethoxazole through regulating AKT/AMPK pathway., PMID:40436289
The Ameliorative Effect of Adipose-Derived Mesenchymal Stem Cells and Their Exosomes in Non-alcoholic Steatohepatitis by Simultaneously Enhancing Autophagic Flux and Suppressing Endoplasmic Reticulum Stress., PMID:40438157
Sigma-1 Receptor Activation Alleviates iBRB Dysfunction after I/R Injury by Inhibiting Endoplasmic Reticulum Stress-Dependent Autophagy., PMID:40450632
Transcriptional regulation of solute carrier family 6 member 9 gene., PMID:40461883
Glutamate promotes triple-negative breast cancer development through IRE1α/XBP1-mediated macrophage polarization: mechanism insights and therapy., PMID:40471465
Endoplasmic Reticulum Stress and Liver Cancer: Regulation Through Natural Products., PMID:40472069
Impact of ATF6 deletion on the embryonic brain development., PMID:40487428
Role of anethole dithiolethione regulating liver lipid metabolism, oxidative and ER stress in NAFLD: Insights from a mouse model., PMID:40501246
Hyptolide induces ER stress-mediated cell death and enhances GSK3β-regulated cisplatin chemosensitivity in ovarian cancer., PMID:40506749
Loss of FIC-1-mediated AMPylation activates the UPRER and upregulates cytosolic HSP70 chaperones to suppress polyglutamine toxicity., PMID:40512832
Quercetin-loaded exosomes delivery system prevents myopia progression by targeting endoplasmic reticulum stress and ferroptosis in scleral fibroblasts., PMID:40520556
Endoplasmic reticulum stress pathways and cellular death mechanisms in patients with phenylketonuria., PMID:40522434
ATF6 enables pathogen infection in ticks by inducing stomatin and altering cholesterol dynamics., PMID:40526719
Ershiwuwei Shanhu pills alleviates cerebral ischemia injury in rats by regulating endoplasmic reticulum stress through GRP78/XBP1/CHOP pathway., PMID:40532596
The endoplasmic reticulum stress response: A link with tuberculosis? PMID: 26980496
[Activating transcription factor 6-C/EBP homologous protein pathway mediates advanced glycated albumin-induced macrophage apoptosis]. PMID: 29270592
High expression of active ATF6 aggravates endoplasmic reticulum stress‑induced vascular endothelial cell apoptosis through the mitochondrial apoptotic pathway. PMID: 29512699
Transmembrane bZIP transcription factors in ER stress signaling and the unfolded protein response. PMID: 17887918
p38 Mitogen-activated protein kinase mediates the transcriptional induction of the atrial natriuretic factor gene through a serum response element. A potential role for the transcription factor ATF6. PMID: 9685422
Hepatitis C virus NS2 protein triggers endoplasmic reticulum stress and suppresses its own viral replication. PMID: 20801537
Regulation of microRNA expression in the heart by the ATF6 branch of the ER stress response. PMID: 22326432
Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. PMID: 11256944
Endoplasmic Reticulum-Associated Biomarkers for Molecular Phenotyping of Rare Kidney Disease. PMID: 33671535
Activation of the unfolded protein response by Listeria monocytogenes. PMID: 22321539
An IFN-γ-stimulated ATF6-C/EBP-β-signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy. PMID: 22699507
Grass carp (Ctenopharyngodon idella) ATF6 (activating transcription factor 6) modulates the transcriptional level of GRP78 and GRP94 in CIK cells. PMID: 26988288
ER stress-related ATF6 upregulates CIP2A and contributes to poor prognosis of colon cancer. PMID: 30063110
Activation of the unfolded protein response in human acute myeloid leukemia. PMID: 21266233
Interaction of ATF6 and serum response factor. PMID: 9271374
An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1. PMID: 30504459
Activation of the Unfolded Protein Response in Sporadic Inclusion-Body Myositis but Not in Hereditary GNE Inclusion-Body Myopathy. PMID: 25978849
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response. PMID: 10856300
ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage. PMID: 24269637
Quinocetone triggered ER stress-induced autophagy via ATF6/DAPK1-modulated mAtg9a trafficking. PMID: 27085326
[Regulation of osteogenesis and chondrogenesis by unfolded protein respone]. PMID: 22416468
Apelin-13 Alleviates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Endoplasmic Reticulum Stress-mediated Apoptosis and Blood-Brain Barrier Disruption: Possible Involvement of ATF6/CHOP Pathway. PMID: 30036660
Repression of viral gene expression and replication by the unfolded protein response effector XBP1u. PMID: 32065579
The unfolded protein response is triggered following a single, unaccustomed resistance-exercise bout. PMID: 25009220
Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. PMID: 12014989
Arsenic trioxide induces unfolded protein response in vascular endothelial cells. PMID: 23892647
Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress. PMID: 22802018
The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels. PMID: 19667116
Downregulation of RIP3 Improves the Protective Effect of ATF6 in an Acute Liver Injury Model. PMID: 34778458
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. PMID: 11850408
[Pathogenic Mechanism of Diabetes Development Due to Dysfunction of Unfolded Protein Response]. PMID: 27252061
The UPR signaling molecule ATF6 is a poor prognostic marker in gastric cancer. PMID: 35835674
Roles of Grp78 in Female Mammalian Reproduction. PMID: 28389754
Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection. PMID: 30842332
Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis. PMID: 30063920
ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein. PMID: 25444553
BiP binding keeps ATF6 at bay. PMID: 12110159
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles. PMID: 19822759
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes. PMID: 31028913
Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs. PMID: 34186245
Cerebral ischemia and the unfolded protein response. PMID: 15379881
High-content screening identifies inhibitors of the nuclear translocation of ATF6. PMID: 26707144
Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response. PMID: 19561103
Differences in Unfolded Protein Response Pathway Activation in the Lenses of Three Types of Cataracts. PMID: 26091066
Stress-sensing mechanisms in the unfolded protein response: similarities and differences between yeast and mammals. PMID: 19942680
The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress. PMID: 22268789
Sensing endoplasmic reticulum stress. PMID: 22399379
Proteome and Glycoproteome Analyses Reveal the Protein N-Linked Glycosylation Specificity of STT3A and STT3B. PMID: 36139350
Luminal domain of ATF6 alone is sufficient for sensing endoplasmic reticulum stress and subsequent transport to the Golgi apparatus. PMID: 21150130
Selective activation of ATF6 and PERK endoplasmic reticulum stress signaling pathways prevent mutant rhodopsin accumulation. PMID: 22956602
Physiological unfolded protein response regulated by OASIS family members, transmembrane bZIP transcription factors. PMID: 21438114
The effects of IRE1, ATF6, and PERK signaling on adRP-linked rhodopsins. PMID: 24664756
ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1. PMID: 10866666
Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein. PMID: 21521793
The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms. PMID: 30086303
Modulation of the unfolded protein response by GRP78 in prostate cancer. PMID: 21266234
Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway. PMID: 18840095
Explore on the effect of ATF6 on cell growth and apoptosis in cartilage development. PMID: 24934104
Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response. PMID: 17092596
Redox signaling loops in the unfolded protein response. PMID: 22481091
Expressions of ATF6, XBP1, and GRP78 in normal tissue, atypical adenomatous hyperplasia, and adenocarcinoma of the lung. PMID: 30121368
The role of ORMDL3/ATF6 in compensated beta cell proliferation during early diabetes. PMID: 31061237
Role of the unfolded protein response in cell death. PMID: 16374548
PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response. PMID: 26674075
Endoplasmic reticulum stress sensing in the unfolded protein response. PMID: 23388626
Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization. PMID: 23395094
[Unfolded protein response: its role in physiology and physiopathology]. PMID: 17349291
Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16. PMID: 11909875
Hepatitis C virus core protein activates autophagy through EIF2AK3 and ATF6 UPR pathway-mediated MAP1LC3B and ATG12 expression. PMID: 24589849
LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis. PMID: 36044268
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. PMID: 10564271
Unfolded protein response activation in cataracts. PMID: 25263040
The unfolded protein response. PMID: 12692187
ATF6 modulates SREBP2-mediated lipogenesis. PMID: 14765107
Modulation of Unfolded Protein Response by Methylmercury. PMID: 28867746
Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response. PMID: 14699159
The unfolded protein response and Alzheimer's disease. PMID: 11406343
Identification and functional characterization of unfolded protein response transcription factor ATF6 gene in kuruma shrimp Marsupenaeus japonicus. PMID: 29427718
Profile of the unfolded protein response in rat cerebellar cortical development. PMID: 31132146
Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in plants. PMID: 26060134
Unfolding the unfolded protein response: unique insights into brain ischemia. PMID: 25830481
Peste des Petits Ruminants Virus Upregulates STING to Activate ATF6-Mediated Autophagy. PMID: 36197111
Trichostatin A increases BDNF protein expression by improving XBP-1s/ATF6/GRP78 axis in Schwann cells of diabetic peripheral neuropathy. PMID: 33378965
Molecular signal networks and regulating mechanisms of the unfolded protein response. PMID: 28070992
A novel role of ER stress signal transducer ATF6 in regulating enterovirus A71 viral protein stability. PMID: 29386036
Divest yourself of a preconceived idea: transcription factor ATF6 is not a soluble protein! PMID: 20219975
Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation. PMID: 17686766
Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. PMID: 21841196
A review of the mammalian unfolded protein response. PMID: 21809331
Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stress. PMID: 29851562
Evolutionary Aspects of the Unfolded Protein Response. PMID: 35940910
The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein. PMID: 24043630
Transcriptional factor ATF6 is involved in odontoblastic differentiation. PMID: 24570149
Lipid-dependent regulation of the unfolded protein response. PMID: 25543896
Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis. PMID: 32138230
SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation. PMID: 27911441
BMP2 protein regulates osteocalcin expression via Runx2-mediated Atf6 gene transcription. PMID: 22102412
Endoplasmic reticulum-stress and unfolded protein response-activation in immune-mediated necrotizing myopathy. PMID: 35703068
Non-Structural Protein 2B of Human Rhinovirus 16 Activates Both PERK and ATF6 Rather Than IRE1 to Trigger ER Stress. PMID: 30717233
Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein. PMID: 31105062
ATF6 deficiency damages the development of spermatogenesis in male Atf6 knockout mice. PMID: 34904262
ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors. PMID: 35626697
The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6. PMID: 19304306
The Epstein-Barr Virus Lytic Protein BMLF1 Induces Upregulation of GRP78 Expression through ATF6 Activation. PMID: 33919712
Avian reovirus infection activate the cellular unfold protein response and induced apoptosis via ATF6-dependent mechanism. PMID: 33741393
SUMOylation represses the transcriptional activity of the Unfolded Protein Response transducer ATF6. PMID: 29061306
Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome. PMID: 27217380
Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response. PMID: 34623328
Going for the Golgi: small PDI protein helps ATF6 perform better under stress. PMID: 31328793
Gremlin-1 Promotes Colorectal Cancer Cell Metastasis by Activating ATF6 and Inhibiting ATF4 Pathways. PMID: 35883579
The Ca2+ -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6. PMID: 33960419
Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress. PMID: 32673694
Alterations of EDEM1 functions enhance ATF6 pro-survival signaling. PMID: 30281916
Mfn2 modulates the UPR and mitochondrial function via repression of PERK. PMID: 23921556
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. PMID: 11163209
ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb. PMID: 30582446
ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. PMID: 30241539
ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart. PMID: 27932512
ATF6 aggravates acinar cell apoptosis and injury by regulating p53/AIFM2 transcription in Severe Acute Pancreatitis. PMID: 32724472
Roles for ATF6 and the sarco/endoplasmic reticulum protein quality control system in the heart. PMID: 24140798
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. PMID: 11779464
Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases. PMID: 32854418
For research use only. Not for human or drug use.
