Genetics and Epigenetics of Alzheimer's Disease: Understanding Pathogenesis and Exploring Therapeutic Potential., PMID:40447964
Compositional and functional gut microbiota alterations in mild cognitive impairment: links to Alzheimer's disease pathology., PMID:40448221
From genetic roots to recent advancements in gene therapy targeting amyloid beta in Alzheimer's disease., PMID:40448320
Melatonin modulates mitochondrial function and inhibits atherosclerosis progression through NRF2 activation and OPA1 inhibition., PMID:40449269
Apolipoprotein E as a potential regulator of osteoclast-osteoblast coupling in material-induced bone formation., PMID:40449705
Macrophage histone lactylation in atherosclerosis progression: mechanisms, predictive models, and therapeutic potential of Ruan Jian Qing Mai formula., PMID:40449878
Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer's disease., PMID:40450296
Associations between platelet indices and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: the CABLE study., PMID:40450373
APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses., PMID:40451545
Causal association of cholesterol metabolism-related proteins with hepatocellular carcinoma and dysfunction-associated steatotic liver disease: a mendelian randomization study., PMID:40455174
Spatial navigation deficits in early Alzheimer's disease: the role of biomarkers and APOE genotype., PMID:40456910
Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype., PMID:40457456
A rare gain of function variant of hepatic lipase attenuates hypercholesterolemia and atherosclerosis in mice via an LDL receptor-independent mechanism., PMID:40460236
Biomimetic nanocomplexes loading with evolocumab and curcumin for synergistic anti-atherosclerosis therapy in ApoE-/- mice., PMID:40462197
Heritability of Alzheimer-related plasma biomarkers in the Amish population., PMID:40463532
Serum heat inactivation diminishes ApoE-mediated uptake of D-Lin-MC3-DMA lipid nanoparticles., PMID:40463820
The lipidome and proteome of high-density lipoprotein are altered in menopause., PMID:40465474
Alzheimer's disease plasma biomarkers in the Midwestern Amish., PMID:40465679
Unveiling XinJia-LuHuang Granules' protective mechanism against atherosclerosis: Integrating network pharmacology, metabolomics, and experimental validation., PMID:40466509
IFITM1 promotes proliferation, migration and macrophage-like transdifferentiation of vascular smooth muscle cells via c-Src/MAPK/GATA2/E2F2 pathway in atherosclerosis., PMID:40466954
High-phytosterol rapeseed oil prevents atherosclerosis by reducing intestinal barrier dysfunction and cholesterol uptake in ApoE-/- mice., PMID:40467190
Lipid metabolism disorder promoting retinal structural and functional damage in ApoE-/- mice with age superposition., PMID:40468378
Single-nucleus multiomics in brains from Hispanic individuals reveal APOE-ε4 -driven disruption of focal adhesion signaling in the presence of cerebrovascular pathology., PMID:40475150
Chimpanzee and human ApoE isoforms differ in the stimulation of neurite differentiation consistent with structural predictions with relevance to brain development and aging., PMID:40475510
Association of Alzheimer's disease concerns with amyloid burden and lifestyle behaviors in cognitively unimpaired older adults., PMID:40476544
Clinically relevant dosing of miR-145 micelles curbs atherosclerosis in vivo., PMID:40480516
PCSK9 inhibition mitigates vulnerable plaque formation induced by hyperhomocysteinemia through regulating lipid metabolism and inflammation., PMID:40480522
Unraveling novel mechanisms of ATP-Binding cassette (ABC) transporter in insulin Resistance-induced amyloidogenesis., PMID:40482009
Cell-type-specific Transcriptomic-wide Association Studies Detected 91 Independent Risk Genes for Alzheimer's Disease Dementia., PMID:40492066
Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: Unraveling the interplay with risk of dementia., PMID:40492085
Perceptual discrimination of complex objects: Apolipoprotein E e4 gene-dose effects in mid-life., PMID:40492513
Salivary levels of amyloid beta reflect brain amyloid beta burden in cognitively-normal older adults., PMID:40494737
Pre-treatment serum apolipoprotein E: a promising prognostic indicator for nasopharyngeal carcinoma., PMID:40495209
GWAS links APOE to neuropsychiatric symptoms in mild cognitive impairment and dementia., PMID:40495575
Impact of APOE4-related dementia risk in underrepresented groups from the All of Us research program., PMID:40501118
Robust Serum Proteomic Signatures of APOE2., PMID:40501769
Fucosterol exerts an anti-atherosclerotic action via NF-κB and p38/Erk MAPK signaling pathways., PMID:40502621
Therapeutic potential of Cordyceps militaris cultivated with Ginkgo biloba seeds for alleviating western diet-induced type 2 diabetes and diabetic nephropathy., PMID:40510419
Impact of serum lipids on prognosis in breast cancer patients: a systematic review and meta-analysis., PMID:40514653
Correlation between clinical classification and genetic analysis of familial hypercholesterolemia in premature coronary artery disease in a cohort of Egyptian patients., PMID:40517278
Non-esterified fatty acids disrupt hepatic lipid metabolism and mitochondrial function via TLR4/MyD88/IRAK2 signaling in bovine hepatocytes., PMID:40518053
Contribution of multimodal ultrasound in evaluating the efficacy of lumbricus protein fast dissolving tablets against atherosclerotic plaques in ApoE(-/-) mice., PMID:40520209
Assembled human microbiome and metabolome in chronic kidney disease: Dysbiosis a double-edged sword interlinking Circ-YAP1, Circ-APOE & Circ-SLC8A1., PMID:40520523
Fusarium spp. and Aspergillus flavus infection induces pathogen-specific and pathogen-independent host immune response in patients with fungal keratitis., PMID:40521031
FAK activity exacerbates disturbed flow-mediated atherosclerosis via VEGFR2-CBL-NF-κB signaling., PMID:40523617
Xiong's Shiwei Wendan decoction attenuates plaque lesions and balances gut microbiota dysbiosis in ApoE-/- mice with high-fat diet., PMID:40524290
Catechin inhibits ox-LDL-induced ferroptosis in vascular smooth muscle cells to alleviate and stabilize atherosclerosis., PMID:40529424
Mechanism of Red Yeast Rice in the Improvement of Atherosclerosis in Apolipoprotein E-deficient Mice Explored Through Metabolomics Combined with Serum Pharmacochemistry and Network Pharmacology., PMID:40531242
Microglial pruning of glycinergic synapses disinhibits spinal PKCγ interneurons to drive pain hypersensitivity in mice., PMID:40531965
Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer's disease dementia., PMID:40533815
[Apo-E phenotype]. PMID: 10543062
Apolipoprotein E4: an allele associated with many diseases. PMID: 10766403
Apolipoprotein E forms stable complexes with recombinant Alzheimer's disease beta-amyloid precursor protein. PMID: 9224643
Apolipoprotein (apo) E genotype and apoE concentration determine binding of normal very low density lipoproteins to HepG2 cell surface receptors. PMID: 8808766
Lipoprotein glomerulopathy induced by ApoE-Sendai is different from glomerular lesions in aged apoE-deficient mice. PMID: 19459027
Apolipoprotein E binds to and reduces serum levels of DNA-mimicking, pyrrolated proteins. PMID: 31167785
APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis. PMID: 12957508
An ApoE-Abeta inhibition complex in Abeta fibril extension. PMID: 8939715
Analysis of apolipoprotein E nuclear localization using green fluorescent protein and biotinylation approaches. PMID: 17961126
Plaque attack. Mice without ApoE and related protein unexpectedly accumulate beta-amyloid deposits. PMID: 14749520
Age-related binding of proximal region of ApoE promoter to nuclear proteins of mouse cerebral cortex. PMID: 21643978
The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor. PMID: 15863833
Recombinant neural protein PrP can bind with both recombinant and native apolipoprotein E in vitro. PMID: 16953297
Exercise modulates APOE expression in brain cortex of female APOE3 and APOE4 targeted replacement mice. PMID: 36434832
The cell and molecular biology of apolipoprotein E synthesis by macrophages. PMID: 3525037
The role of apolipoprotein E in bone metabolism. PMID: 21798384
Molecular pathogenesis of apolipoprotein E-mediated amyloidosis in late-onset Alzheimer's disease. PMID: 11212354
Apolipoprotein E: possible therapeutic target for atherosclerosis. PMID: 12769659
Molecular design and modeling of protein-heparin interactions. PMID: 1762571
Cholesterol and apoe: a target for Alzheimer's disease therapeutics. PMID: 16266288
Measurement of apolipoprotein E (apoE) in cerebrospinal fluid. PMID: 10823584
The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection. PMID: 10899434
A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier. PMID: 22572854
ApoE deficiency: markedly decreased levels of cellular ApoE mRNA. PMID: 3004475
Apolipoprotein E and the apolipoprotein E-deficient mouse. PMID: 8527231
Is epsilon4 the ancestral human apoE allele? PMID: 10604434
A Biophysical Approach to the Identification of Novel ApoE Chemical Probes. PMID: 30700058
ApoE synthesis in human neuroblastoma cells. PMID: 9440124
Endogenous ApoE expression modulates adipocyte triglyceride content and turnover. PMID: 17130485
Apolipoprotein E Facilitates Amyloid-β Oligomer-Induced Tau Phosphorylation. PMID: 32065788
Gene sequences regulating the production of apoE and cerebral palsy of variable severity. PMID: 24786335
Amyloid A protein amyloidosis induced in apolipoprotein-E-deficient mice. PMID: 9327723
Influence of metformin on mitochondrial subproteome in the brain of apoE knockout mice. PMID: 26712380
Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. PMID: 22393530
Understanding Dengue Virus Capsid Protein Interaction with Key Biological Targets. PMID: 26161501
New and confirmatory evidence of an association between APOE genotype and baseline C-reactive protein in dyslipidemic individuals. PMID: 15530909
Apolipoprotein E polymorphism and susceptibility to Alzheimer's disease. PMID: 7729825
Conformational Reorganization of Apolipoprotein E Triggered by Phospholipid Assembly. PMID: 33979165
S-nitrosylation of ApoE in Alzheimer's disease. PMID: 21443265
Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseases. PMID: 20531185
Mechanisms of enhanced macrophage apoE secretion by oxidized LDL. PMID: 9186915
Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease. PMID: 32036033
Loss of cellular inhibitor of apoptosis protein 2 reduces atherosclerosis in atherogenic apoE-/- C57BL/6 mice on high-fat diet. PMID: 24072531
Role of estrogen in women's Alzheimer's disease risk as modified by APOE. PMID: 36420620
Endocytosis of apoE-EGFP by primary human brain cultures. PMID: 12377208
Apolipoprotein E: from lipid transport to neurobiology. PMID: 20854843
Lipid composition dependent binding of apolipoprotein E signal peptide: Importance of membrane cholesterol in protein trafficking. PMID: 36228459
Apolipoproteins and aging: emerging mechanisms. PMID: 12067591
Apolipoprotein E imbalance in the cerebrospinal fluid of Alzheimer's disease patients. PMID: 36324176
The influence of apoE-deficiency and LDL-receptor-deficiency on the HDL subpopulation profile in mice and in humans. PMID: 24529120
Cross-talk between apolipoprotein E and cytokines. PMID: 21772670
Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein. PMID: 16401069
Association of apoE gene expression and its gene polymorphism with nephrotic syndrome susceptibility: a meta-analysis of experimental and human studies. PMID: 22760259
The Complex Role of Apolipoprotein E in Alzheimer's Disease: an Overview and Update. PMID: 27647307
Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta deposition in vivo. PMID: 10936884
Apolipoprotein ε7 allele in memory complaints: insights through protein structure prediction. PMID: 28744113
Association of APOE Serum Levels and APOE ε2, ε3, and ε4 Alleles with Optic Neuritis. PMID: 35885971
A multi-hit hypothesis for an APOE4-dependent pathophysiological state. PMID: 35510513
Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype. PMID: 37072097
In vitro and in cellulo ApoE particle formation, isolation, and characterization. PMID: 36595894
The Role of Apolipoprotein E Isoforms in Alzheimer's Disease. PMID: 30775980
The cell biology and physiologic relevance of ApoE recycling. PMID: 11150725
ApoE: the role of conserved residues in defining function. PMID: 25377861
Few serum proteins mediate APOE's association with dementia. PMID: 28291794
Role of ApoE in conformation-prone diseases and atherosclerosis. PMID: 16903824
Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. PMID: 19474305
Physical interaction of ApoE with amyloid precursor protein independent of the amyloid Abeta region in vitro. PMID: 9593736
Links between ApoE, brain cholesterol metabolism, tau and amyloid beta-peptide in patients with cognitive impairment. PMID: 20658997
The role of apolipoprotein E in neurodegeneration and cardiovascular disease. PMID: 24754513
Impact of apoE genotype on oxidative stress, inflammation and disease risk. PMID: 18203129
Apolipoprotein E in Cardiometabolic and Neurological Health and Diseases. PMID: 36077289
Effects of different isoforms of apoE on aggregation of the α-synuclein protein implicated in Parkinson's disease. PMID: 26921451
Sex differences in the formation of atherosclerosis lesion in apoE-/-mice and the effect of 17β-estrodiol on protein S-nitrosylation. PMID: 29665642
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. PMID: 16687490
Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. PMID: 9547235
Inconstant apolipoprotein E (ApoE)-like immunoreactivity in amyloid beta protein deposits: relationship with APOE genotype in aging brain and Alzheimer's disease. PMID: 8841664
Signaling pathway factors expression in renal tissue of apoE-knockout mice. PMID: 26096163
The interaction of amyloid-beta with ApoE. PMID: 15709483
APOE at the BBB: Pericyte-Derived Apolipoprotein E4 Diminishes Endothelial Cell Barrier Function. PMID: 31869265
APOE Genotypes Modulate Inflammation Independently of Their Effect on Lipid Metabolism. PMID: 36361733
APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention. PMID: 33647674
Fragmentation of brain apolipoprotein E (ApoE) and its relevance in Alzheimer's disease. PMID: 32364519
Protein oligomerization as a metabolic control mechanism: Application to apoE. PMID: 30701627
ApoE in atherosclerosis : a protein with multiple hats. PMID: 10938002
APOE genetics influence murine gut microbiome. PMID: 35115575
APOE*ε4 promotes synucleinopathy. PMID: 32107475
A serum protein signature of APOE genotypes in centenarians. PMID: 31385390
Apoprotein E and Reverse Cholesterol Transport. PMID: 30404132
Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases. PMID: 25173806
Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease. PMID: 30598326
Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease. PMID: 28434655
Understanding the Role of ApoE Fragments in Alzheimer's Disease. PMID: 30225748
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients. PMID: 35915083
Isoform- and cell-state-specific lipidation of ApoE in astrocytes. PMID: 35235798
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases. PMID: 36153580
Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation. PMID: 33556209
The role of APOE on lipid homeostasis and inflammation in normal brains. PMID: 28258087
ApoE and Neurodegenerative Diseases in Aging. PMID: 30232753
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches. PMID: 33340485
Evolution of human apolipoprotein E (APOE) isoforms: Gene structure, protein function and interaction with dietary factors. PMID: 28647612
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