Catalog No.
YHK28201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala460-Ser520
Predicted molecular weight
35.28 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N695
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Apical iodide transporter, Sodium-coupled monocarboxylate transporter 1, SMCT1, AIT, Sodium iodide-related cotransporter, SMCT, Solute carrier family 5 member 8, Electrogenic sodium monocarboxylate cotransporter, SLC5A8
Potential Role of SLC5A8 Expression in the Etiology of Subacute Ruminal Acidosis. PMID: 32850999
Structure and mechanism of the SGLT family of glucose transporters. PMID: 34880492
Short-Chain Fatty Acid Transporters: Role in Colonic Homeostasis. PMID: 29357130
Protein expressions and genetic variations of SLC5A8 in prostate cancer risk and aggressiveness. PMID: 21802122
Downregulation of SLC5A8 inhibits hepatocellular carcinoma progression through regulation of Wnt/β-catenin signaling. PMID: 27465549
SLC5A8 regulates the biological behaviors of cervical cancer cells through mediating the Wnt signaling pathway. PMID: 32432731
Identification and characterization of the human SLC5A8 gene promoter. PMID: 20082847
Molecular mechanism of SLC5A8 inactivation in breast cancer. PMID: 23918800
The effect of valproic acid on SLC5A8 expression in gonad-intact and gonadectomized rat thymocytes. PMID: 35120418
Gene silencing of SLC5A8 identified by genome-wide methylation profiling in lung cancer. PMID: 23273563
Urinary ketone body loss leads to degeneration of brain white matter in elderly SLC5A8-deficient mice. PMID: 31506013
Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate. PMID: 15322102
SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinoma. PMID: 22450368
Activin A induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells. PMID: 20732443
Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells. PMID: 21508099
SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter. PMID: 16375929
Candidate tumor suppressor gene SLC5A8 is frequently down-regulated by promoter hypermethylation in prostate tumor. PMID: 18037591
Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice. PMID: 18562324
SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. PMID: 12829793
The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function. PMID: 23167260
[The methylation and mRNA expression of SLC5A8 and TMS1/ASC genes in human glioma]. PMID: 17456354
Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer. PMID: 15361710
Biological functions of SLC5A8, a candidate tumour suppressor. PMID: 15667316
Hypermethylated RASSF1 and SLC5A8 promoters alongside BRAFV600E mutation as biomarkers for papillary thyroid carcinoma. PMID: 32017063
Silencing of the tumor suppressor gene SLC5A8 is associated with BRAF mutations in classical papillary thyroid carcinomas. PMID: 15687339
Integrative analysis of DNA methylation and gene expression identified cervical cancer-specific diagnostic biomarkers. PMID: 31871774
Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer. PMID: 18661192
Gut-derived butyrate suppresses ocular surface inflammation. PMID: 35296712
SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases. PMID: 17178845
Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions. PMID: 25984582
SLC5A8 gene, a transporter of butyrate: a gut flora metabolite, is frequently methylated in African American colon adenomas. PMID: 21687703
Histochemical demonstration of a Na(+)-coupled transporter for short-chain fatty acids (slc5a8) in the intestine and kidney of the mouse. PMID: 16295698
Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter. PMID: 20211600
Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8. PMID: 20033346
Transport of haloacids across biological membranes. PMID: 27668346
Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. PMID: 18446519
Identification of the multivalent PDZ protein PDZK1 as a binding partner of sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8) and SMCT2 (SLC5A12). PMID: 30604288
The increased protein level of URAT1 was observed in obesity/metabolic syndrome model mice. PMID: 22132989
Helicobacter pylori Infection Is Associated with Decreased Expression of SLC5A8, a Cancer Suppressor Gene, in Young Children. PMID: 27777899
Circulating cell-free DNA, SLC5A8 and SLC26A4 hypermethylation, BRAF(V600E): A non-invasive tool panel for early detection of thyroid cancer. PMID: 23931930
Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids. PMID: 14966140
Iodide transport and breast cancer. PMID: 26285906
A new paradigm for a new simple chemical: butyrate & immune regulation. PMID: 34752597
Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate. PMID: 19637353
Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8. PMID: 15867356
Gene methylation in thyroid tumorigenesis. PMID: 16946009
The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. PMID: 15090606
miR-29a, b, and c regulate SLC5A8 expression in intestinal epithelial cells. PMID: 34231393
Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 (SLC5A8) in human pancreatic cancer. PMID: 18437076
Sodium-coupled monocarboxylate transporter is a target of epigenetic repression in cervical cancer. PMID: 30896789
DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication. PMID: 18566324
Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases. PMID: 20601425
Insulin and SGK1 reduce the function of Na+/monocarboxylate transporter 1 (SMCT1/SLC5A8). PMID: 27488665
Genome-Wide Analysis of Dental Caries Variability Reveals Genotype-by-Environment Interactions. PMID: 36981009
Transport of 2,4-dichloro phenoxyacetic acid by human Na+-coupled monocarboxylate transporter 1 (hSMCT1, SLC5A8). PMID: 30583944
Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8. PMID: 17099289
Gastric Damage and Cancer-Associated Biomarkers in Helicobacter pylori-Infected Children. PMID: 32117120
Deficiency of Dietary Fiber in Slc5a8-Null Mice Promotes Bacterial Dysbiosis and Alters Colonic Epithelial Transcriptome towards Proinflammatory Milieu. PMID: 31976310
Tamm-Horsfall protein/uromodulin deficiency elicits tubular compensatory responses leading to hypertension and hyperuricemia. PMID: 29357410
Prognostic Significance of Aberrant Methylation of Solute Carrier Gene Family 5A8 in Lung Adenocarcinoma. PMID: 25827678
Smartphone-Based Electrochemiluminescence for Visual Simultaneous Detection of RASSF1A and SLC5A8 Tumor Suppressor Gene Methylation in Thyroid Cancer Patient Plasma. PMID: 35616262
Interaction of ibuprofen and other structurally related NSAIDs with the sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8). PMID: 16729224
Sodium-coupled monocarboxylate transporter 1 interacts with the RING finger- and PDZ domain-containing protein PDZRN3. PMID: 31098988
Iodide Binding in Sodium-Coupled Cotransporters. PMID: 29131623
Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate. PMID: 21499304
Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain. PMID: 16805814
Diclofenac-induced stimulation of SMCT1 (SLC5A8) in a heterologous expression system: a RPE specific phenomenon. PMID: 20178774
SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms. PMID: 27118869
New insights into renal transport of urate. PMID: 17278930
c/ebpdelta Null mouse as a model for the double knock-out of slc5a8 and slc5a12 in kidney. PMID: 16873376
The drug of abuse gamma-hydroxybutyrate is a substrate for sodium-coupled monocarboxylate transporter (SMCT) 1 (SLC5A8): characterization of SMCT-mediated uptake and inhibition. PMID: 19389857
Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host. PMID: 23978504
Validation of nucleolar protein 4 as a novel methylated tumor suppressor gene in head and neck cancer. PMID: 24337411
Transducing bioelectric signals into epigenetic pathways during tadpole tail regeneration. PMID: 22933452
Cellular expression of a sodium-dependent monocarboxylate transporter (Slc5a8) and the MCT family in the mouse kidney. PMID: 18751721
Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family. PMID: 15651982
Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina. PMID: 17591909
Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. PMID: 18992769
For research use only. Not for human or drug use.
