Persistent Respiratory Distress in the Term Neonate: Genetic Surfactant Deficiency Diseases., PMID:31544695
A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis., PMID:31601679
SP-A and TLR4 localization in lung tissue of SM-exposed patients., PMID:31718931
Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival., PMID:31953311
Surfactant protein A as a biomarker of outcomes of anti-fibrotic drug therapy in patients with idiopathic pulmonary fibrosis., PMID:32005219
Dexamethasone Treatment Increases the Intracellular Calcium Level Through TRPV6 in A549 Cells., PMID:32033337
Association of SNP-SNP Interactions of Surfactant Protein Genes with Pediatric Acute Respiratory Failure., PMID:32326132
Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer., PMID:32587780
Sex-Specific Regulation of Gene Expression Networks by Surfactant Protein A (SP-A) Variants in Alveolar Macrophages in Response to Klebsiella pneumoniae., PMID:32670284
Functional assessment and phenotypic heterogeneity of SFTPA1 and SFTPA2 mutations in interstitial lung diseases and lung cancer., PMID:32855221
Genetic Features of Lung Adenocarcinoma with Ground- Glass Opacity: What Causes the Invasiveness of Lung Adenocarcinoma?, PMID:33020345
GLP-1 receptor agonist ameliorates experimental lung fibrosis., PMID:33093510
Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice., PMID:33141765
Novel rare genetic variants in idiopathic pulmonary fibrosis., PMID:33361455
SNP and Haplotype Interaction Models Reveal Association of Surfactant Protein Gene Polymorphisms With Hypersensitivity Pneumonitis of Mexican Population., PMID:33469544
miR-296-5p Inhibits the Secretion of Pulmonary Surfactants in Pulmonary Epithelial Cells via the Downregulation of Wnt7b/β-Catenin Signaling., PMID:33490270
Genetic variants of small airways and interstitial pulmonary disease in children., PMID:33526882
Krebs von den Lungen-6 and surfactant protein-A in interstitial pneumonia with autoimmune features., PMID:33530214
Identification of a novel subset of alveolar type 2 cells enriched in PD-L1 and expanded following pneumonectomy., PMID:33863742
CRISPRi-mediated functional analysis of NKX2-1-binding sites in the lung., PMID:33980985
SFTPA1 is a potential prognostic biomarker correlated with immune cell infiltration and response to immunotherapy in lung adenocarcinoma., PMID:34181042
Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions., PMID:34484180
Comparative analysis on lung transcriptome of Mycoplasma ovipneumoniae (Mo) - infected Bashbay sheep and argali hybrid sheep., PMID:34645427
Lung cancer is also a hereditary disease., PMID:34670806
Single Nucleotide Polymorphisms Interactions of the Surfactant Protein Genes Associated With Respiratory Distress Syndrome Susceptibility in Preterm Infants., PMID:34671583
Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants., PMID:34917085
SNP-SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children., PMID:35401703
Single Nucleotide Polymorphisms (SNP) and SNP-SNP Interactions of the Surfactant Protein Genes Are Associated With Idiopathic Pulmonary Fibrosis in a Mexican Study Group; Comparison With Hypersensitivity Pneumonitis., PMID:35720392
Hydrophilic But Not Hydrophobic Surfactant Protein Genetic Variants Are Associated With Severe Acute Respiratory Syncytial Virus Infection in Children., PMID:35903101
Single nucleotide polymorphisms in surfactant protein A1 are not associated with a lack of responsiveness to antenatal steroid therapy in a pregnant sheep model., PMID:36200269
A potential treatment option for transformed small-cell lung cancer on PD-L1 inhibitor-based combination therapy improved survival., PMID:36473332
The Genetic and Epigenetic Footprint in Idiopathic Pulmonary Fibrosis and Familial Pulmonary Fibrosis: A State-of-the-Art Review., PMID:36553114
[Interstitial lung diseases in children of genetic origin]., PMID:36564324
Injury activated alveolar progenitors (IAAPs): the underdog of lung repair., PMID:37166489
Molecular insights using spatial transcriptomics of the distal lung in congenital diaphragmatic hernia., PMID:37605849
Sevoflurane with Low Concentration Decrease DNA Methylation on Chronic Obstructive Pulmonary Disease (COPD)-Related Gene Promoter in COPD Rat., PMID:38010369
Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx., PMID:38375572
Development of an in vitro human alveolar epithelial air-liquid interface model using a small molecule inhibitor cocktail., PMID:38500038
High risk of lung cancer in surfactant-related gene variant carriers., PMID:38575158
Human surfactant protein A inhibits SARS-CoV-2 infectivity and alleviates lung injury in a mouse infection model., PMID:38596675
Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury., PMID:38689083
Multi-omics analysis of diabetic pig lungs reveals molecular derangements underlying pulmonary complications of diabetes mellitus., PMID:38900131
Association of SNP-SNP interactions of surfactant protein genes with severity of respiratory syncytial virus infection in children., PMID:39222066
Differential Immunoregulation by Human Surfactant Protein A Variants Determines Severity of SARS-CoV-2-induced Lung Disease., PMID:39314485
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury., PMID:39515667
Surfactant Protein A Inhibits Human Rhinovirus C Binding and Infection of Airway Epithelial Cells from Pediatric Asthma., PMID:39599822
Surfactant protein levels and genetic variants as biomarkers for COVID-19 severity in children., PMID:39832502
Differential immunoregulation by human surfactant protein A variants determines severity of SARS-CoV-2-induced lung disease., PMID:40242753
ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells., PMID:40437524
Human SP-A protein variants derived from one or both genes stimulate TNF-alpha production in the THP-1 cell line. PMID: 10781424
Autophagy proteins are required for club cell structure and function in airways. PMID: 31116580
5' splicing and allelic variants of the human pulmonary surfactant protein A genes. PMID: 7811473
Lipopolysaccharide stimulates syntheses of toll-like receptor 2 and surfactant protein-A in human alveolar epithelial A549 cells through upregulating phosphorylation of MEK1 and ERK1/2 and sequential activation of NF-κB. PMID: 21474333
Association of pulmonary surfactant protein A (SP-A) gene and respiratory distress syndrome: interaction with SP-B. PMID: 9475280
Genetic variants of small airways and interstitial pulmonary disease in children. PMID: 33526882
Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes. PMID: 17407567
Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population. PMID: 10762543
miR-296-5p Inhibits the Secretion of Pulmonary Surfactants in Pulmonary Epithelial Cells via the Downregulation of Wnt7b/β-Catenin Signaling. PMID: 33490270
Differential effects of human SP-A1 and SP-A2 variants on phospholipid monolayers containing surfactant protein B. PMID: 17678872
Polymorphisms of surfactant protein A genes and the risk of bronchopulmonary dysplasia in preterm infants. PMID: 11105614
SP-A and TLR4 localization in lung tissue of SM-exposed patients. PMID: 31718931
Surfactant protein (SP) B associations and interactions with SP-A in white and black subjects with respiratory distress syndrome. PMID: 11737731
Surfactant protein A2 (SP-A2) variants expressed in CHO cells stimulate phagocytosis of Pseudomonas aeruginosa more than do SP-A1 variants. PMID: 17220308
Surfactant-associated protein inhibits phospholipid secretion from type II cells. PMID: 3654429
Alveolyn--structure and source: a review. PMID: 6386449
Effect of surfactant protein A on lipopolysaccharide-induced tumor necrosis factor-α expression in human proximal tubular epithelial cells. PMID: 24438626
Non-invasive prenatal testing reveals copy number variations related to pregnancy complications. PMID: 31485271
Lung fibrosis-associated surfactant protein A1 and C variants induce latent transforming growth factor β1 secretion in lung epithelial cells. PMID: 23926107
Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure. PMID: 23525782
Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants. PMID: 25326576
Structural characterisation of human proteinosis surfactant protein A. PMID: 11087951
Genetics of the hydrophilic surfactant proteins A and D. PMID: 9813381
Survival of Surfactant Protein-A1 and SP-A2 Transgenic Mice After Klebsiella pneumoniae Infection, Exhibits Sex-, Gene-, and Variant Specific Differences; Treatment With Surfactant Protein Improves Survival. PMID: 30459763
Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study. PMID: 21310059
Systematic review of drug effects in humans and models with surfactant-processing disease. PMID: 29997245
Dexamethasone Treatment Increases the Intracellular Calcium Level Through TRPV6 in A549 Cells. PMID: 32033337
CRISPRi-mediated functional analysis of NKX2-1-binding sites in the lung. PMID: 33980985
SNP and Haplotype Interaction Models Reveal Association of Surfactant Protein Gene Polymorphisms With Hypersensitivity Pneumonitis of Mexican Population. PMID: 33469544
Surfactant protein A2 gene expression by human airway submucosal gland cells. PMID: 9698591
14-3-3 isoforms bind directly exon B of the 5'-UTR of human surfactant protein A2 mRNA. PMID: 26001776
Relationship between surfactant protein A polymorphisms and allergic rhinitis in a Chinese Han population. PMID: 20963503
Injury activated alveolar progenitors (IAAPs): the underdog of lung repair. PMID: 37166489
DNA methylation profile and expression of surfactant protein A2 gene in lung cancer. PMID: 25514367
Sex-Specific Regulation of Gene Expression Networks by Surfactant Protein A (SP-A) Variants in Alveolar Macrophages in Response to Klebsiella pneumoniae. PMID: 32670284
Identification and Quantitation of Coding Variants and Isoforms of Pulmonary Surfactant Protein A. PMID: 25025725
Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress. PMID: 20466729
Peptide regulation of gene expression and protein synthesis in bronchial epithelium. PMID: 25015171
The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation. PMID: 21840962
Immunologic identification of a pulmonary surfactant-associated protein of molecular weight = 6000 daltons. PMID: 3526265
Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate. PMID: 19797132
Hydrophilic But Not Hydrophobic Surfactant Protein Genetic Variants Are Associated With Severe Acute Respiratory Syncytial Virus Infection in Children. PMID: 35903101
Insertions and Deletions Target Lineage-Defining Genes in Human Cancers. PMID: 28089356
GLP-1 receptor agonist ameliorates experimental lung fibrosis. PMID: 33093510
Persistent Respiratory Distress in the Term Neonate: Genetic Surfactant Deficiency Diseases. PMID: 31544695
Genetic characterization of a Chinese family with familial idiopathic pulmonary fibrosis. PMID: 22884059
Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection. PMID: 24950659
Surfactant Protein A and B Gene Polymorphisms and Risk of Respiratory Distress Syndrome in Late-Preterm Neonates. PMID: 27835691
Human Pulmonary Surfactant Protein SP-A1 Provides Maximal Efficiency of Lung Interfacial Films. PMID: 27508436
Krebs von den Lungen-6 and surfactant protein-A in interstitial pneumonia with autoimmune features. PMID: 33530214
Eosinophil-associated lung diseases. A cry for surfactant proteins A and D help? PMID: 24960334
A new tool to investigate differences between human SP-A1 and SP-A2. PMID: 17293378
Genetic complexity of the human innate host defense molecules, surfactant protein A1 (SP-A1) and SP-A2--impact on function. PMID: 19392648
SNP-SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children. PMID: 35401703
Surfactant protein A is defective in abrogating inflammation in asthma. PMID: 21784968
Surfactant protein A as a biomarker of outcomes of anti-fibrotic drug therapy in patients with idiopathic pulmonary fibrosis. PMID: 32005219
Genetic causes and clinical management of pediatric interstitial lung diseases. PMID: 29517585
Hyaline membrane disease and surfactant protein, SAP-35, in diabetes in pregnancy. PMID: 3048286
Single Nucleotide Polymorphisms Interactions of the Surfactant Protein Genes Associated With Respiratory Distress Syndrome Susceptibility in Preterm Infants. PMID: 34671583
Humanized SFTPA1 and SFTPA2 transgenic mice reveal functional divergence of SP-A1 and SP-A2: formation of tubular myelin in vivo requires both gene products. PMID: 20048345
[Interstitial lung diseases in children of genetic origin]. PMID: 36564324
Retinal degeneration mutation in Sftpa1tm1Kor/J and Sftpd -/- targeted mice. PMID: 29969487
Correlation analysis between single nucleotide polymorphisms of pulmonary surfactant protein A gene and pulmonary tuberculosis in the Han population in China. PMID: 24984162
Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene. PMID: 20693318
Differential Impact of Co-expressed SP-A1/SP-A2 Protein on AM miRNome; Sex Differences. PMID: 31475015
Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions. PMID: 34484180
Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2. PMID: 23069847
Long-range PCR based sequencing of the highly homologous genes, SFTPA1 and SFTPA2. PMID: 23354021
Surfactant protein A--from genes to human lung diseases. PMID: 17168848
Association of SNP-SNP Interactions of Surfactant Protein Genes with Pediatric Acute Respiratory Failure. PMID: 32326132
Novel rare genetic variants in idiopathic pulmonary fibrosis. PMID: 33361455
An 11-nt sequence polymorphism at the 3'UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture. PMID: 24793167
Identification and examination of a novel 9-bp insert/deletion polymorphism on porcine SFTPA1 exon 2 associated with acute lung injury using an oleic acid-acute lung injury model. PMID: 25442010
Identification of a novel subset of alveolar type 2 cells enriched in PD-L1 and expanded following pneumonectomy. PMID: 33863742
Germline SFTPA1 mutation in familial idiopathic interstitial pneumonia and lung cancer. PMID: 26792177
The Genetic and Epigenetic Footprint in Idiopathic Pulmonary Fibrosis and Familial Pulmonary Fibrosis: A State-of-the-Art Review. PMID: 36553114
A novel germline mutation of the SFTPA1 gene in familial interstitial pneumonia. PMID: 30854216
Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences. PMID: 29394894
Single Nucleotide Polymorphisms (SNP) and SNP-SNP Interactions of the Surfactant Protein Genes Are Associated With Idiopathic Pulmonary Fibrosis in a Mexican Study Group; Comparison With Hypersensitivity Pneumonitis. PMID: 35720392
Surfactant protein A and D polymorphisms and methylprednisolone pharmacogenetics in donor lungs. PMID: 30827536
Functional assessment and phenotypic heterogeneity of SFTPA1 and SFTPA2 mutations in interstitial lung diseases and lung cancer. PMID: 32855221
Association of common haplotypes of surfactant protein A1 and A2 (SFTPA1 and SFTPA2) genes with severity of lung disease in cystic fibrosis. PMID: 16429424
Single nucleotide polymorphisms in surfactant protein A1 are not associated with a lack of responsiveness to antenatal steroid therapy in a pregnant sheep model. PMID: 36200269
Pulmonary Fibrosis Predisposition Overview. PMID: 20301408
Variants of the SFTPA1 and SFTPA2 genes and susceptibility to tuberculosis in Ethiopia. PMID: 16292672
A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis. PMID: 31601679
Direct interaction of surfactant protein A with myometrial binding sites: signaling and modulation by bacterial lipopolysaccharide. PMID: 17202387
Genetic Association of Pulmonary Surfactant Protein Genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD With Cystic Fibrosis. PMID: 30333828
Surfactant protein A signaling pathways in human uterine smooth muscle cells. PMID: 18463356
Lung cancer is also a hereditary disease. PMID: 34670806
SFTPA1 is a potential prognostic biomarker correlated with immune cell infiltration and response to immunotherapy in lung adenocarcinoma. PMID: 34181042
Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants. PMID: 34917085
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