Catalog No.
YHK89701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr78-Thr298
Predicted molecular weight
27.21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y2C4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ENDOGL2, Endo G-like 1, EXOG, Nuclease EXOG, mitochondrial, ENGL, Endonuclease G-like 1, ENDOGL1
Human EXOG Possesses Strong AP Hydrolysis Activity: Implication on Mitochondrial DNA Base Excision Repair. PMID: 36516439
PGC-1ɑ Mediated-EXOG, a Specific Repair Enzyme for Mitochondrial DNA, Plays an Essential Role in the Rotenone-Induced Neurotoxicity of PC12 Cells. PMID: 33515431
In vitro reconstitution reveals a key role of human mitochondrial EXOG in RNA primer processing. PMID: 35819194
A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease. PMID: 28466855
Loss of mitochondrial exo/endonuclease EXOG affects mitochondrial respiration and induces ROS-mediated cardiomyocyte hypertrophy. PMID: 25377088
In EXOG-depleted cardiomyocytes cell death is marked by a decreased mitochondrial reserve capacity of the electron transport chain. PMID: 27417117
EXOG, a novel paralog of Endonuclease G in higher eukaryotes. PMID: 18187503
A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication. PMID: 30949702
Rhizobium meliloti exoG and exoJ mutations affect the exoX-exoY system for modulation of exopolysaccharide production. PMID: 2050634
Mitochondrial nucleases ENDOG and EXOG participate in mitochondrial DNA depletion initiated by herpes simplex virus 1 UL12.5. PMID: 23986585
Differential patterns of activity displayed by two exo-beta-1,3-glucanases associated with the Aspergillus fumigatus cell wall. PMID: 9150209
Anti-Aβ Antibody Aducanumab Regulates the Proteome of Senile Plaques and Closely Surrounding Tissue in a Transgenic Mouse Model of Alzheimer's Disease. PMID: 33252074
Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair. PMID: 21768646
Mitochondrial DNA damage induced autophagy, cell death, and disease. PMID: 26709760
The generation of oxidative stress-induced rearrangements in Saccharomyces cerevisiae mtDNA is dependent on the Nuc1 (EndoG/ExoG) nuclease and is enhanced by inactivation of the MRX complex. PMID: 23276591
The relationship between peripheral glucose utilisation and insulin sensitivity in the regulation of hepatic glucose production: studies in normal and alloxan-diabetic dogs. PMID: 16222656
Production and characterization of recombinant protein preparations of Endonuclease G-homologs from yeast, C. elegans and humans. PMID: 20382228
Eating microRNAs: pharmacological opportunities for cross-kingdom regulation and implications in host gene and gut microbiota modulation. PMID: 33644849
Lipid peroxidation in the kidney of rats treated with V and/or Mg in drinking water. PMID: 20309841
Lipid peroxidation in the liver of rats treated with V and/or Mg in drinking water. PMID: 19557770
Exosome-Based Cell Homing and Angiogenic Differentiation for Dental Pulp Regeneration. PMID: 36613910
Repair of persistent strand breaks in the mitochondrial genome. PMID: 22138376
Germline whole exome sequencing of a family with appendiceal mucinous tumours presenting with pseudomyxoma peritonei. PMID: 32357859
Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics. PMID: 27808278
Deficiency in repair of the mitochondrial genome sensitizes proliferating myoblasts to oxidative damage. PMID: 24066171
Ecotoxicological effects of soil lithium on earthworm Eisenia fetida: Lethality, bioaccumulation, biomarker responses, and histopathological changes. PMID: 37127236
Linear mitochondrial DNA is rapidly degraded by components of the replication machinery. PMID: 29712893
Further evidence that prolactin does not affect gonadotropin release at pituitary level. PMID: 3323020
Mechanism of cellulase reaction on pure cellulosic substrates. PMID: 19061239
Expression profiles and clinical value of plasma exosomal Tim-3 and Galectin-9 in non-small cell lung cancer. PMID: 29452091
Molecular characterization of a new member of the lariat capping twin-ribozyme introns. PMID: 25342998
Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function. PMID: 25378300
Genetic analysis of a cluster of genes required for synthesis of the calcofluor-binding exopolysaccharide of Rhizobium meliloti. PMID: 2842306
Genetic association of single nucleotide polymorphisms in endonuclease G-like 1 gene with type 2 diabetes in a Japanese population. PMID: 17415550
[ON THE PROBLEM OF EXOGENOUS CARCINOGENESIS]. PMID: 14077282
[FACTORS CONDITIONING THE MASCULINIZING ACTION ON THE HUMAN FETUS OF ANDROGENS, EXOGENOUS AND ENDOGENOUS]. PMID: 14304468
[NEUTRALIZATION OF EXOGENOUS HEPARIN BY SUBEQUIVALENT DOSES OF PROTAMINE OR POLYBRENE AFTER AFTIFICIAL PERFUSIONS]. PMID: 14151023
[STUDY OF THE COURSE OF THE BLOOD CALCIUM IN RATS DEPRIVED OF THE CALCIUM UTILIZATION EXOGENIC FACTOR. OBSERVATION OF A BEHAVIOR DIFFERING ACCORDING TO SEX]. PMID: 14141657
[INFLUENCE OF EXOGENOUS PROGESTERONE ON PROTEIN METABOLISM IN THE OVARIECTOMIZED SOW DURING THE ESTRUS CYCLE OR DURING PREGNANCY]. PMID: 14162965
[ACTION OF ENDOGENOUS AND EXOGENOUS SUBSTANCES ON NERVE TISSUE IN CULTURE]. PMID: 14141573
For research use only. Not for human or drug use.
