Catalog No.
YHH00701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys35-Gln139
Predicted molecular weight
24.93 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15059
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BRD3, RING3-like protein, Bromodomain-containing protein 3, KIAA0043, RING3L
NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment. PMID: 30362654
Skin adnexal carcinoma with BRD3-NUTM2B fusion. PMID: 34296453
BRD3-NUTM1-expressing NUT carcinoma of lung on endobronchial ultrasound-guided transbronchial needle aspiration cytology, a diagnostic pitfall. PMID: 34672128
Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. PMID: 37043564
The BET family in immunity and disease. PMID: 33462181
Cutaneous Primary NUT Carcinoma With BRD3-NUTM1 Fusion. PMID: 34482332
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation. PMID: 32895492
BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs. PMID: 32324495
BRD2 interconnects with BRD3 to facilitate Pol II transcription initiation and elongation to prime promoters for cell differentiation. PMID: 35665862
Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes. PMID: 34813359
Epigenetic readers and lung cancer: the rs2427964C>T variant of the bromodomain and extraterminal domain gene BRD3 is associated with poorer survival outcome in NSCLC. PMID: 34605158
BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis. PMID: 28733670
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer. PMID: 31969702
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. PMID: 27274052
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. PMID: 32193360
[Brd3 promotes IL-6 production via enhancing acetylase CBP recruitment and histone 3 acetylation within IL6 promoter]. PMID: 27667451
Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes. PMID: 21536911
Long noncoding RNA NEAT1 decreases polycystic ovary syndrome progression via the modulation of the microRNA-324-3p and BRD3 axis. PMID: 36040750
BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells. PMID: 29240787
Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages. PMID: 28045112
Author Correction: Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages. PMID: 33262417
The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators. PMID: 29567837
Reply to: Expanding the Spectrum of Primary Cutaneous Carcinoma With BRD3-NUTM1 Fusion. PMID: 34469332
Large-scale discovery of novel neurodevelopmental disorder-related genes through a unified analysis of single-nucleotide and copy number variants. PMID: 35468861
Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation. PMID: 34520194
BCL6 confers KRAS-mutant non-small-cell lung cancer resistance to BET inhibitors. PMID: 33393503
[Expression of BRD7-interacting proteins,BRD2 and BRD3, in nasopharyngeal carcinoma tissues]. PMID: 12600283
Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines. PMID: 37084596
A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins. PMID: 33592170
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. PMID: 26035625
ATRX loss promotes immunosuppressive mechanisms in IDH1 mutant glioma. PMID: 34951647
Targeting BET Proteins BRD2 and BRD3 in Combination with PI3K-AKT Inhibition as a Therapeutic Strategy for Ovarian Clear Cell Carcinoma. PMID: 33509905
Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression. PMID: 30786900
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma. PMID: 33016928
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. PMID: 28805820
Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes. PMID: 27158652
Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections. PMID: 35622893
BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell. PMID: 27008626
The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. PMID: 18406326
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. PMID: 28805822
BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia. PMID: 35958877
NUT midline carcinoma. PMID: 20951314
Three calcium-sensitive genes, fus, brd3 and wdr5, are highly expressed in neural and renal territories during amphibian development. PMID: 23287019
Pharmacological Modulation of BET Family in Sepsis. PMID: 33776776
Phospho-BRD4: transcription plasticity and drug targeting. PMID: 27769352
BET proteins: Biological functions and therapeutic interventions. PMID: 36739915
Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3. PMID: 21555453
Case report of a pan-cytokeratin negative NUT midline carcinoma of pulmonary origin, a BRD3-NUT variant: Challenges in cytomorphologic presentation. PMID: 37021735
Dihydropyridine Lactam Analogs Targeting BET Bromodomains. PMID: 34932262
NUT Carcinoma: Clinicopathologic Features, Molecular Genetics and Epigenetics. PMID: 35372003
Identification of photocrosslinking peptide ligands by mRNA display. PMID: 37258712
Establishment of environment-sensitive probes targeting BRD3/BRD4 for imaging and therapy of tumor. PMID: 37269669
Systematic analysis of the BET family in adrenocortical carcinoma: The expression, prognosis, gene regulation network, and regulation targets. PMID: 36793283
A 33-Year-Old Man With Chest Pain. PMID: 35000716
BRD4: New hope in the battle against glioblastoma. PMID: 37061146
Identification of unique, differentiation stage-specific patterns of expression of the bromodomain-containing genes Brd2, Brd3, Brd4, and Brdt in the mouse testis. PMID: 15261828
Small-Molecule Targeting of BET Proteins in Cancer. PMID: 27451123
Bromodomains as therapeutic targets in cancer. PMID: 23543289
Targeting the BET family for the treatment of leukemia. PMID: 24811781
Pre-sertoli specific gene expression profiling reveals differential expression of Ppt1 and Brd3 genes within the mouse genital ridge at the time of sex determination. PMID: 15128596
Pathogenesis of NUT midline carcinoma. PMID: 22017582
For research use only. Not for human or drug use.
