Anti-CHI3L1 Polyclonal Antibody

Catalog No.

PHE16901

Species reactivity

Human, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CHI3L1 (Asn112-Lys377).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

CHI3L1,GP-39,YKL-40,Chitinase-3-like protein 1,CGP-39,39 kDa synovial protein,hCGP-39,Cartilage glycoprotein 39

Purification

Purified by antigen affinity column.

Accession

P36222

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Macrophage activation determines muscle wasting in pancreatic cancer., PMID:40442475

CSF proteomics of semorinemab Alzheimer's disease trials identifies cell-type specific signatures., PMID:40435316

Anti-CHI3L1 antibody suppresses colon cancer growth through downregulation of VEGFA and NAMPT expression., PMID:40377878

Anti-arthritis Effect of Anti-chitinase-3-like 1 Antibody Through Inhibition of MMP3., PMID:40342842

Chitinase 3-like protein 1 deficiency ameliorates drug-induced acute liver injury by inhibition of neutrophil recruitment through lipocalin-2., PMID:40196357

Combination therapy with Chicoric acid and PD-1/PD-L1 blockade improves the immunotherapy response in patient-derived ovarian cancer xenograft model., PMID:40087780

Biological signatures in the Alzheimer's continuum discriminate between diagnosis-related and -unrelated associations to ATN categories., PMID:40046342

Omics data integration analysis identified new biological insights into chronic antibody-mediated rejection (CAMR)., PMID:39979925

Targeting of Ykl-40 as a Protumor in Personalized Medicine: A New Dimension in Disease Understanding., PMID:39976089

Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications., PMID:39827337

Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis., PMID:39813006

Activated kynurenine pathway metabolism by YKL-40 establishes an inhibitory immune microenvironment and drives glioblastoma development., PMID:39718635

Novel Interacting Partners of MGP-40, a Chitinase-Like Protein in Buffalo Mammary Epithelial Cells., PMID:39579292

Pharmacodynamic effects of semorinemab on plasma and CSF biomarkers of Alzheimer's disease pathophysiology., PMID:39513754

BTK and YKL-40 Levels and Their Association with Acute AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorder., PMID:39485631

Cohort study of serological biomarkers for interstitial lung disease in patients with rheumatoid arthritis., PMID:39450495

Predictive and Dynamic Signature for Antiangiogenics in Combination with a PD1 Inhibitor in Soft-Tissue Sarcoma: Correlative Studies Linked to the IMMUNOSARC Trial., PMID:39283727

Predictive value of serum HIF-1α/HIF-2α and YKL-40 levels for vascular invasion and prognosis of follicular thyroid cancer., PMID:39277981

Chitinase 3-like-1 (CHI3L1) in the pathogenesis of epidermal growth factor receptor mutant non-small cell lung cancer., PMID:39178575

Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism., PMID:39090679

Discovery of crucial cytokines associated with deep vein thrombus formation by protein array analysis., PMID:39026176

Predictive potential of serum and cerebrospinal fluid biomarkers for disease activity in treated multiple sclerosis patients., PMID:38909525

A humanized Anti-YKL-40 antibody inhibits tumor development., PMID:38824968

Fully human chitinase-3 like-1 monoclonal antibody inhibits tumor growth, fibrosis, angiogenesis, and immune cell remodeling in lung, pancreatic, and colorectal cancers., PMID:38820971

Anti-chitinase-3-like 1 antibody attenuated atopic dermatitis-like skin inflammation through inhibition of STAT3-dependent CXCL8 expression., PMID:38745399

Changes in metabolic parameters and serum YKL-40 levels in Chinese rheumatoid arthritis patients during tocilizumab therapy., PMID:38696116

Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial., PMID:38683602

Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models., PMID:38605414

Location-based prediction model for Crohn's disease regarding a novel serological marker, anti-chitinase 3-like 1 autoantibodies., PMID:38075846

The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer., PMID:38039967

The potential roles and mechanisms of Chitinase-3-like-1 in the pathogenesis of type 2-biased airway diseases., PMID:38036279

Clinically isolated syndrome: Diagnosis and risk of developing clinically definite multiple sclerosis., PMID:37858891

Chitinase-3-like 1 regulates TH2 cells, TFH cells and IgE responses to helminth infection., PMID:37575256

Deciphering the Action of Neuraminidase in Glioblastoma Models., PMID:37511403

Chitinase 3-Like-1 Expression Is Upregulated Under Inflammatory Conditions in Human Oral Epithelial Cells., PMID:37380444

Chi3l1 Is a Modulator of Glioma Stem Cell States and a Therapeutic Target in Glioblastoma., PMID:37101376

CHI3L1 in the CSF is a potential biomarker for anti-leucine-rich glioma inactivated 1 encephalitis., PMID:36685530

A novel humanized Chi3l1 blocking antibody attenuates acetaminophen-induced liver injury in mice., PMID:36683763

CHI3L1 enhances melanoma lung metastasis via regulation of T cell co-stimulators and CTLA-4/B7 axis., PMID:36618349

Oligoclonal band versus chitinase-3-like protein-1 in CSF of newly diagnosed relapsing remitting multiple sclerosis., PMID:36591957

Serum CHI3L1 as a Biomarker for Non-invasive Diagnosis of Liver Fibrosis., PMID:36274212

Host chitinase 3-like-1 is a universal therapeutic target for SARS-CoV-2 viral variants in COVID-19., PMID:35735790

Targeting Chitinase 1 and Chitinase 3-Like 1 as Novel Therapeutic Strategy of Pulmonary Fibrosis., PMID:35370755

High Levels of Cerebrospinal Fluid Kappa Free Light Chains Relate to IgM Intrathecal Synthesis and Might Have Prognostic Implications in Relapsing Multiple Sclerosis., PMID:35330910

Host Chitinase 3-like-1 is a Universal Therapeutic Target for SARS-CoV-2 Viral Variants in COVID 19., PMID:35118470

Anti-TNF Agents Restrict Adherent-invasive Escherichia coli Replication Within Macrophages Through Modulation of Chitinase 3-like 1 in Patients with Crohn's Disease., PMID:35022663

Targeting protumor factor chitinase-3-like-1 secreted by Rab37 vesicles for cancer immunotherapy., PMID:34987649

Chitinase 3-like 1 secreted from cancer-associated fibroblasts promotes tumor angiogenesis via interleukin-8 secretion in colorectal cancer., PMID:34913066

Anti-Chi3L1 antibody suppresses lung tumor growth and metastasis through inhibition of M2 polarization., PMID:34861103

Paralysis of the cytotoxic granule machinery is a new cancer immune evasion mechanism mediated by chitinase 3-like-1., PMID:34824159

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