Catalog No.
YHK88501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser540-Asp653
Predicted molecular weight
15.36 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y2J4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LCCP, AMOTL2, Angiomotin-like protein 2, Leman coiled-coil protein, KIAA0989
AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches. PMID: 34165350
AMOTL2‑knockdown promotes the proliferation, migration and invasion of glioma by regulating β‑catenin nuclear localization. PMID: 34036399
FKBP51, AmotL2 and IQGAP1 Involvement in Cilastatin Prevention of Cisplatin-Induced Tubular Nephrotoxicity in Rats. PMID: 35563891
AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells. PMID: 32950569
AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation. PMID: 34323359
AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation. PMID: 34404733
IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment. PMID: 30794467
AMOTL2 interaction with TAZ causes the inhibition of surfactant proteins expression in lung cells. PMID: 23911299
Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. PMID: 17293535
The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish. PMID: 22362771
MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis. PMID: 33707576
Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle. PMID: 23525008
AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion. PMID: 25080976
AmotL2 integrates polarity and junctional cues to modulate cell shape. PMID: 28790366
AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion. PMID: 24806444
Myocyte enhancer factor 2D promotes hepatocellular carcinoma through AMOTL2/YAP signaling that inhibited by luteolin. PMID: 35698637
The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching. PMID: 28842668
Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis. PMID: 21937427
Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness. PMID: 25998128
Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension. PMID: 32166015
mRNA-miRNA-lncRNA Regulatory Network in Nonalcoholic Fatty Liver Disease. PMID: 34202571
Hypoxic Tumor-Derived Exosomal Long Noncoding RNA UCA1 Promotes Angiogenesis via miR-96-5p/AMOTL2 in Pancreatic Cancer. PMID: 32942233
Angiomotin-like 2 interacts with and negatively regulates AKT. PMID: 28368415
Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition. PMID: 26598551
Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2. PMID: 37131806
Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor. PMID: 21832154
Angiomotin Family Members: Oncogenes or Tumor Suppressors? PMID: 28656002
The physiological role of Motin family and its dysregulation in tumorigenesis. PMID: 29650031
Suppression of YAP safeguards human naïve pluripotency. PMID: 36398796
Integrative analysis of exosomal microRNA-149-5p in lung adenocarcinoma. PMID: 33658392
Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation. PMID: 22813598
Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway. PMID: 32385107
The role of Motin family proteins in tumorigenesis-an update. PMID: 36973516
Podosomes in muscle cells and their role in the remodeling of neuromuscular postsynaptic machinery. PMID: 25012928
Angiomotin'g YAP into the nucleus for cell proliferation and cancer development. PMID: 24003252
The Hsp70-Bag3 complex modulates the phosphorylation and nuclear translocation of Hippo pathway protein Yap. PMID: 34761265
Evaluation of the role of kefir in management of non-alcoholic steatohepatitis rat model via modulation of NASH linked mRNA-miRNA panel. PMID: 36604518
Connecting physical cues and tissue patterning. PMID: 26473744
Overlooked long-chain chlorinated paraffin (LCCP) contamination in foodstuff from China. PMID: 34467914
How Low-Carbon Pilots Affect Chinese Urban Energy Efficiency: An Explanation from Technological Progress. PMID: 36497638
Effectiveness of Lilly Connected Care Program (LCCP) App-Based Diabetes Education for Patients With Type 2 Diabetes Treated With Insulin: Retrospective Real-World Study. PMID: 32141838
How to Achieve Carbon Neutrality in Cities? Evidence from China's Low-Carbon Cities Development. PMID: 36767488
Evaluation of China's low-carbon city pilot policy: Evidence from 210 prefecture-level cities. PMID: 34618870
Assessing the low-carbon city pilot policy on carbon emission from consumption and production in China: how underlying mechanism and spatial spillover effect? PMID: 35610453
Effectiveness of the Family Portal Function on the Lilly Connected Care Program (LCCP) for Patients With Type 2 Diabetes: Retrospective Cohort Study With Propensity Score Matching. PMID: 33544081
Has China's Low-Carbon City Construction Enhanced the Green Utilization Efficiency of Urban Land? PMID: 36011480
The impact of low-carbon city pilot policy on green total-factor productivity in China's cities. PMID: 36334204
Does Low-Carbon City Pilot Policy Alleviate Urban Haze Pollution? Empirical Evidence from a Quasi-Natural Experiment in China. PMID: 34769802
Effectiveness of the Lilly Connected Care Program in Improving Glycemic Management Among Patients With Type 2 Diabetes in China: Retrospective Real-world Study. PMID: 37097724
Does low-carbon city pilot affect the enterprise competitiveness in China? Based on a staggered difference-in-difference model. PMID: 36571678
Impact of Low-Carbon City Policy on Enterprise Investment Efficiency: Based on the Heterogeneity of Chinese Urban Culture. PMID: 36193413
GREEN-MAC-LCCP: a tool for assessing the life cycle climate performance of MAC systems. PMID: 20812721
The Low-Carbon Policy and Urban Green Total Factor Energy Efficiency: Evidence from a Spatial Difference-in-Difference Method. PMID: 36834192
Does the low-carbon city pilot policy work in China? A company-level analysis based on the PSM-DID model. PMID: 36933536
Pathological characteristics of light chain crystalline podocytopathy. PMID: 36581019
Devising new lipid-coated calcium phosphate/carbonate hybrid nanoparticles for controlled release in endosomes for efficient gene delivery. PMID: 32263910
Can low-carbon city construction reduce carbon intensity？Empirical evidence from low-carbon city pilot policy in China. PMID: 36736083
Environmental Risks of Medium-Chain Chlorinated Paraffins (MCCPs): A Review. PMID: 29791144
Medium- and long-chain chlorinated paraffins in air: A review of levels, physicochemical properties, and analytical considerations. PMID: 35779735
Risk assessment of chlorinated paraffins in feed and food. PMID: 32874241
Evaluation of the Effectiveness of a Multimodal Complementary Medicine Program for Improving the Quality of Life of Cancer Patients during Adjuvant Radiotherapy and/or Chemotherapy or Outpatient Aftercare. PMID: 28472802
The personal development tutor role: an exploration of student and lecturer experiences and perceptions of that relationship. PMID: 24467865
Novel metal sites in protein structures. PMID: 8994881
Polyelectrolyte-grafted anion exchangers with hydrophilic intermediate layers for ion chromatography. PMID: 36166883
Seasonal variation of short-, medium- and long-chain chlorinated paraffin distribution in Belgian indoor dust. PMID: 36370602
Advances in kinetic protein crystallography. PMID: 16129597
Short-, medium-, and long-chain chlorinated paraffins in South African indoor dust and cat hair. PMID: 31473532
Chlorinated Paraffins in Human Milk from Urban Sites in China, Sweden, and Norway. PMID: 32101003
For research use only. Not for human or drug use.
