Catalog No.
PHE14101
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TIMP3 (Cys24-Pro211).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Protein MIG-5,TIMP-3,Tissue inhibitor of metalloproteinases 3,TIMP3,Metalloproteinase inhibitor 3
Purification
Purified by antigen affinity column.
Accession
P35625
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Transcriptomic and functional characterization of megakaryocytic-derived platelet-like particles: impaired aggregation and prominent anti-tumor effects., PMID:39812346
Elevated Serum Gastrin Is Associated with Melanoma Progression: Putative Role in Increased Migration and Invasion of Melanoma Cells., PMID:38069171
Sublytic C5b-9 induces TIMP3 expression by glomerular mesangial cells via TRAF6-dependent KLF5 K63-linked ubiquitination in rat Thy-1 nephritis., PMID:37748221
Single-cell analysis of dorsal root ganglia reveals metalloproteinase signaling in satellite glial cells and pain., PMID:37557960
Deciphering the Action of Neuraminidase in Glioblastoma Models., PMID:37511403
Evaluation of Matrix Metalloproteases by Artificial Intelligence Techniques in Negative Biopsies as New Diagnostic Strategy in Prostate Cancer., PMID:37108185
An atlas of the bone marrow bone proteome in patients with dysproteinemias., PMID:37105956
An atlas of the bone marrow bone proteome in patients with dysproteinemias., PMID:36747663
Among biomarkers of neutrophil activity, matrix metalloproteinases 8 independently predicts remission of metabolic syndrome., PMID:36411219
Novel immune-related signature based on immune cells for predicting prognosis and immunotherapy response in clear cell renal cell carcinoma., PMID:35441741
Treatment of Sorsby fundus dystrophy with anti-tumor necrosis factor-alpha medication., PMID:34376817
MicroRNA-197-3p mediates damage to human coronary artery endothelial cells via targeting TIMP3 in Kawasaki disease., PMID:34351574
Expression of microRNA-21 and TIMP-3 in paradoxical psoriasiform reactions during treatment with antitumor necrosis factor agents., PMID:34322902
Current Management and Therapeutic Strategies for Cerebral Amyloid Angiopathy., PMID:33918041
Granulocyte-macrophage colony-stimulating factor initiates amniotic membrane rupture and preterm birth in a mouse model., PMID:33772943
A proteomic approach towards understanding the pathogenesis of Mooren's ulcer., PMID:33647271
Matrix metalloproteinases and their inhibitors in Fuchs endothelial corneal dystrophy., PMID:33617849
Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site., PMID:33504102
Specific Targeting of PEGylated Liposomal Doxorubicin (Doxil®) to Tumour Cells Using a Novel TIMP3 Peptide., PMID:33379361
MAb NJ001 inhibits lung adenocarcinoma invasiveness by directly regulating TIMP-3 promoter activity via FOXP1 binding sites., PMID:32744429
Utility of Glycosylated TIMP3 molecules: Inhibition of MMPs and TACE to improve cardiac function in rat myocardial infarct model., PMID:30459952
TIMP Loss Activates Metalloproteinase-TNFα-DKK1 Axis To Compromise Wnt Signaling and Bone Mass., PMID:30216540
Suramin increases cartilage proteoglycan accumulation in vitro and protects against joint damage triggered by papain injection in mouse knees in vivo., PMID:29299344
Myocilin Regulates Metalloprotease 2 Activity Through Interaction With TIMP3., PMID:29049729
Bilateral choroidal neovascular membrane in a young patient with Sorsby fundus dystrophy: the value of prompt treatment., PMID:28775088
Cardiac fibroblast transcriptome analyses support a role for interferogenic, profibrotic, and inflammatory genes in anti-SSA/Ro-associated congenital heart block., PMID:28626076
Effects of C-reactive protein on the expression of matrix metalloproteinases and their inhibitors via Fcγ receptors on 3T3-L1 adipocytes., PMID:28539825
Modulation of Matrix Metalloproteinase 14, Tissue Inhibitor of Metalloproteinase 3, Tissue Inhibitor of Metalloproteinase 4, and Inducible Nitric Oxide Synthase in the Development of Periapical Lesions., PMID:28527839
Hampered cumulus expansion of porcine cumulus-oocyte complexes by excessive presence of alpha2 -macroglobulin is likely mediated via inhibition of zinc-dependent metalloproteases., PMID:28124491
Matrix metalloproteinases MMP1, MMP2, MMP9 and their tissue inhibitors TIMP1, TIMP2, TIMP3 in head and neck cancer: an immunohistochemical study., PMID:27386931
Using urinary bFGF and TIMP3 levels to predict the presence of juvenile pilocytic astrocytoma and establish a distinct biomarker signature., PMID:27314542
Expression and Clinical Significance of Metalloproteases and Their Inhibitors by Endothelial Cells From Invasive Breast Carcinomas., PMID:27266802
Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and tumor expression of metalloproteases and their inhibitors in invasive breast cancer., PMID:27114340
Toll-like receptor 2 (TLR2) induces migration and invasive mechanisms in rheumatoid arthritis., PMID:26055925
Absence of nicotinic acetylcholine receptor α7 subunit amplifies inflammation and accelerates onset of fibrosis: an inflammatory kidney model., PMID:25985801
Sorsby Fundus Dystrophy: Novel Mutations, Novel Phenotypic Characteristics, and Treatment Outcomes., PMID:25766588
Tissue inhibitors of matrix metalloproteinases in serum are cardiac biomarkers in Emery-Dreifuss muscular dystrophy., PMID:25563468
Knockdown of the AKT3 (PKBγ), PI3KCA, and VEGFR2 genes by RNA interference suppresses glioblastoma multiforme T98G cells invasiveness in vitro., PMID:25501707
Conjunctival matrix metalloproteinases and their inhibitors in glaucoma patients., PMID:25312247
Tumor progression driven by pathways activating matrix metalloproteinases and their inhibitors., PMID:25244188
TIMP-3 expression associates with malignant behaviors and predicts favorable survival in HCC., PMID:25171061
HPV-positive oropharyngeal squamous cell carcinoma is associated with TIMP3 and CADM1 promoter hypermethylation., PMID:25065733
Activation of matrix metalloproteinases 2, 9, and 13 by activated protein C in human osteoarthritic cartilage chondrocytes., PMID:24574263
Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients., PMID:24487271
The use of MMP2 antibody-conjugated cationic microbubble to target the ischemic myocardium, enhance Timp3 gene transfection and improve cardiac function., PMID:24169002
Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile., PMID:23937994
Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units., PMID:23851162
Aberrant promoter methylation of cell adhesion-related genes associated with clinicopathologic features in non-small cell lung cancer in China., PMID:23838140
[Antiangiogenic therapy in Sorsby's fundus dystrophy without a mutation in the TIMP-3 gene]., PMID:23726310
An in vitro model of cartilage degradation by chondrocytes in a three-dimensional culture system., PMID:23675280
For research use only. Not for human or drug use.
