Catalog No.
PHG30301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CDC20 (Gln218-Arg471).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Cell division cycle protein 20 homolog, p55CDC, CDC20
Purification
Purified by antigen affinity column.
Accession
Q12834
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Integrative analysis of serum proteomics and transcriptomics in hepatitis C., PMID:40082995
Inhibition of CDC20 potentiates anti-tumor immunity through facilitating GSDME-mediated pyroptosis in prostate cancer., PMID:37528490
Cell cycle expression of FLJ25439, a cytokinesis-associated protein, is mediated by D-box recognition and APC/C-Cdc20 regulated degradation., PMID:36155061
Identification of Novel Therapeutic Candidates Against SARS-CoV-2 Infections: An Application of RNA Sequencing Toward mRNA Based Nanotherapeutics., PMID:35983322
Wolbachia increase germ cell mitosis to enhance the fecundity of Laodelphax striatellus., PMID:32966874
The closed form of Mad2 is bound to Mad1 and Cdc20 at unattached kinetochores., PMID:29895228
Defective Cyclin B1 Induction in Trastuzumab-emtansine (T-DM1) Acquired Resistance in HER2-positive Breast Cancer., PMID:28821558
Conformation-specific anti-Mad2 monoclonal antibodies for the dissection of checkpoint signaling., PMID:26986935
Prognostic implications of securin expression and sub-cellular localization in human breast cancer., PMID:26984614
The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation., PMID:26912231
Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes., PMID:25938585
Polo-like kinase 1 regulates the stability of the mitotic centromere-associated kinesin in mitosis., PMID:24931513
Risk of type 1 diabetes progression in islet autoantibody-positive children can be further stratified using expression patterns of multiple genes implicated in peripheral blood lymphocyte activation and function., PMID:24595351
Molecular profiling of acute and chronic rejections of renal allografts., PMID:24302958
Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint., PMID:21772247
BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis., PMID:19407811
Cell-cycle-dependent PC-PLC regulation by APC/C(Cdc20)-mediated ubiquitin-proteasome pathway., PMID:19347873
HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint., PMID:18193091
Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1., PMID:18082611
Chromosome elimination in the interspecific hybrid medaka between Oryzias latipes and O. hubbsi., PMID:17603754
Regulation of RUNX1/AML1 during the G2/M transition., PMID:17023045
The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly., PMID:16807356
Overexpression of Cdc20 leads to impairment of the spindle assembly checkpoint and aneuploidization in oral cancer., PMID:16777988
A new Mad2-interacting domain of Cdc20 is critical for the function of Mad2-Cdc20 complex in the spindle assembly checkpoint., PMID:16497171
Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome., PMID:16411201
Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice., PMID:16407851
Mad2 is required for inhibiting securin and cyclin B degradation following spindle depolymerisation in meiosis I mouse oocytes., PMID:16322543
Purification and assay of the budding yeast anaphase-promoting complex., PMID:16275330
Large-scale purification of the vertebrate anaphase-promoting complex/cyclosome., PMID:16275329
Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores., PMID:15964272
Emi1 class of proteins regulate entry into meiosis and the meiosis I to meiosis II transition in Xenopus oocytes., PMID:15701974
The APC subunit Doc1 promotes recognition of the substrate destruction box., PMID:15649358
Changes in the localization of the Saccharomyces cerevisiae anaphase-promoting complex upon microtubule depolymerization and spindle checkpoint activation., PMID:15280225
Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing., PMID:15182667
Mitotic regulation of the human anaphase-promoting complex by phosphorylation., PMID:14657031
Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1., PMID:12859900
The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis., PMID:12429948
The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk., PMID:11859075
Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint., PMID:11707408
Asymmetrical segregation of chromosomes with a normal metaphase/anaphase checkpoint in polyploid megakaryocytes., PMID:11290584
Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint., PMID:11285280
The APC is dispensable for first meiotic anaphase in Xenopus oocytes., PMID:11146630
Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis., PMID:11003657
Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells., PMID:10995431
Destruction of the securin Pds1p occurs at the onset of anaphase during both meiotic divisions in yeast., PMID:10855492
Mad2 binding by phosphorylated kinetochores links error detection and checkpoint action in mitosis., PMID:10375530
Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts., PMID:9649427
Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events., PMID:9628895
DNA polymerase epsilon encoded by cdc20+ is required for chromosomal DNA replication in the fission yeast Schizosaccharomyces pombe., PMID:9605404
Cell cycle-regulated expression, phosphorylation, and degradation of p55Cdc. A mammalian homolog of CDC20/Fizzy/slp1., PMID:9353311
For research use only. Not for human or drug use.
