Catalog No.
PHE41501
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human NR4A2 (Met1-Thr335).
Applications
ELISA, IHC, WB
Recommended Dilution
| Application |
Dilution |
| ELISA |
1:4000-1:8000, IHC: 1:50-1:200, WB: 1:500-1:2000 |
Target
Transcriptionally-inducible nuclear receptor, NURR1, NR4A2, NOT, Nuclear receptor subfamily 4 group A member 2, Orphan nuclear receptor NURR1, TINUR, Immediate-early response protein NOT
Concentration
1 mg/ml
Purification
Purified by antigen affinity column.
Accession
P43354
Form
Liquid
Storage buffer
PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note
For research use only.
Immunochemical studies of human serum proteins. Antigenic inhomogeneities of the gamma globulins, their subunits and number of determinants and their relation to a Waldenstrom macroglobulin., PMID:13863260
Immunoelectrophoretic analysis of rabbit precipitins against human serum proteins. II. Heterologous reaction., PMID:13972397
Immunoelectrophoretic analysis of rabbit precipitins against human serum proteins. I. Homologous reaction., PMID:13972398
[ENDOTOXIN AS AN ADJUVANT. I. EFFECT ON THE LEVEL OF PRECIPITINS AGAINST HUMAN SERUM PROTEINS]., PMID:14203988
[INFLUENCE OF PH AND SALT CONCENTRATION ON THE SOLUBILITY OF HUMAN SERUM PROTEINS IN O.O1 N PHYTIC ACID]., PMID:14278850
Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra., PMID:12209851
Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice., PMID:14742729
Modulation of nurr1 gene expression in mesencephalic dopaminergic neurones., PMID:15009684
Nuclear orphan receptor Nurr1 directly transactivates the osteocalcin gene in osteoblasts., PMID:15485875
Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion., PMID:16243537
Tyrosine hydroxylase gene regulation in human neuronal progenitor cells does not depend on Nurr1 as in the murine and rat systems., PMID:16252282
Efficient generation of dopaminergic neurons from mouse embryonic stem cells enclosed in hollow fibers., PMID:16766027
Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death., PMID:16805795
A role for type 1alpha corticotropin-releasing hormone receptors in mediating local changes in chronically inflamed tissue., PMID:17322394
Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-alpha inhibition., PMID:17671512
Gene Ontology-driven transcriptional analysis of CD34+ cell-initiated megakaryocytic cultures identifies new transcriptional regulators of megakaryopoiesis., PMID:18252802
Identification of a novel nurr1-interacting protein., PMID:18784308
Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development., PMID:19906978
Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer., PMID:20010869
Transgenic mice as a model of pre-clinical Alzheimer's disease., PMID:21143159
Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation., PMID:21621845
Transplantation of neuronal-primed human bone marrow mesenchymal stem cells in hemiparkinsonian rodents., PMID:21625433
Molecular diversity of early-born subplate neurons., PMID:22628460
High-dimensional gene expression profiling studies in high and low responders to primary smallpox vaccination., PMID:22949304
Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation., PMID:24496614
Layer-specific gene expression in epileptogenic type II focal cortical dysplasia: normal-looking neurons reveal the presence of a hidden laminar organization., PMID:24735483
Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFAD mice, an animal model of Alzheimer's disease., PMID:25156412
A genome-wide association study for clinical mastitis in first parity US Holstein cows using single-step approach and genomic matrix re-weighting procedure., PMID:25658712
Chronic Toxoplasma gondii in Nurr1-null heterozygous mice exacerbates elevated open field activity., PMID:25855987
Nuclear receptors of the NR4a family are not required for the development and function of follicular T helper cells., PMID:25899083
Localization of nuclear receptor subfamily 4, group A, member 3 (NR4A3) in Lewy body disease and multiple system atrophy., PMID:26096603
Production of Nurr-1 Specific Polyclonal Antibodies Free of Cross-reactivity Against Its Close Homologs, Nor1 and Nur77., PMID:26325389
Nurr1 overexpression exerts neuroprotective and anti-inflammatory roles via down-regulating CCL2 expression in both in vivo and in vitro Parkinson's disease models., PMID:27940361
Chiro-Optical Modulation for NURR1 Production from Stem Cells., PMID:28452458
cDNA microarray analysis identifies NR4A2 as a novel molecule involved in the pathogenesis of Sjögren's syndrome., PMID:28621822
Sequential cleavage of the proteins encoded by HNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, results in products acting in distinct cellular compartments., PMID:30192950
Pyrethroid exposure and neurotoxicity: a mechanistic approach., PMID:31246571
Low-dose ionizing radiation attenuates mast cell migration through suppression of monocyte chemoattractant protein-1 (MCP-1) expression by Nr4a2., PMID:31287373
Tumor necrosis factor stimulates fibroblast growth factor 23 levels in chronic kidney disease and non-renal inflammation., PMID:31301888
Evaluation of changes in expression pattern of oxidative stress genes under the influence of adalimumab., PMID:31664747
The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma., PMID:34076685
Systematic characterization of the tumor microenvironment in Chinese patients with hepatocellular carcinoma highlights intratumoral B cells as a potential immunotherapy target., PMID:34958112
A minority of cases of acinic cell carcinoma of the salivary glands are driven by an NR4A2 rearrangement: the diagnostic utility of the assessment of NR4A2 and NR4A3 alterations in salivary gland tumors., PMID:36469101
Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy., PMID:39872303
The Promotion of Humoral Immune Responses in Humans via SOCS1-Mediated Th2-Bias Following SARS-CoV-2 Vaccination., PMID:38006062
Tertiary Lymphoid Structures are Linked to Enhanced Antitumor Immunity and Better Prognosis in Muscle-Invasive Bladder Cancer., PMID:39739621
Transcriptomic analysis of chronic chikungunya in the Reunionese CHIKGene cohort uncovers a shift in gene expression more than 10 years after infection., PMID:39999933
For research use only. Not for human or drug use.
