Catalog No.
PHJ34401
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ABCC2 (Ile1300-Glu1534).
Applications
ELISA, IHC, WB
Recommended Dilution
| Application |
Dilution |
| ELISA |
1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000 |
Target
ATP-binding cassette sub-family C member 2, Multidrug resistance-associated protein 2, Canalicular multispecific organic anion transporter 1, ABCC2, CMOAT, Canalicular multidrug resistance protein, MRP2, CMRP, CMOAT1
Purification
Purified by antigen affinity column.
Accession
Q92887
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note
For research use only.
Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2., PMID:15652233
Variable expression of MRP2 (ABCC2) in human placenta: influence of gestational age and cellular differentiation., PMID:15821043
Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis., PMID:15841457
Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B., PMID:16109175
Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats., PMID:16504477
Efflux of baicalin, a flavone glucuronide of Scutellariae Radix, on Caco-2 cells through multidrug resistance-associated protein 2., PMID:17227625
Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell., PMID:17276588
Phloracetophenone-induced choleresis in rats is mediated through Mrp2., PMID:17363469
Upregulation of brain expression of P-glycoprotein in MRP2-deficient TR(-) rats resembles seizure-induced up-regulation of this drug efflux transporter in normal rats., PMID:17437408
Ezrin and radixin both regulate the apical membrane localization of ABCC2 (MRP2) in human intestinal epithelial Caco-2 cells., PMID:17825285
Expression, localization, and inducibility by bile acids of hepatobiliary transporters in the new polarized rat hepatic cell lines, Can 3-1 and Can 10., PMID:17909858
Expression of the multidrug resistance proteins MRP2 and MRP3 in human cholangiocellular carcinomas., PMID:18226047
Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes., PMID:18273864
Expression and localization of ATP binding cassette (ABC) family of drug transporters in gastric hepatoid adenocarcinomas., PMID:18439156
Role of plasma proteins in pharmacokinetics of micafungin, an antifungal antibiotic, in analbuminemic rats., PMID:18591270
Absolute difference of hepatobiliary transporter multidrug resistance-associated protein (MRP2/Mrp2) in liver tissues and isolated hepatocytes from rat, dog, monkey, and human., PMID:18832477
Detection of ABCC2, CYP2B6 and CYP3A4 in human peripheral blood mononuclear cells using flow cytometry., PMID:18929567
Expression of multidrug resistance-associated protein 2 is involved in chemotherapy resistance in human pancreatic cancer., PMID:19020751
Coexpression of invasive markers (uPA, CD44) and multiple drug-resistance proteins (MDR1, MRP2) is correlated with epithelial ovarian cancer progression., PMID:19603017
Effects of Lewis Y antigen on the gene expression of multiple drug resistance-associated proteins in human ovarian cancer RMG-I-H cells., PMID:19771531
[Effect of Lewis y antigen on regulating gene expression of partial drug resistance associated proteins in human ovarian cancer cell line RMG-I-H]., PMID:19771739
High-activity p-glycoprotein, multidrug resistance protein 2, and breast cancer resistance protein membrane vesicles prepared from transiently transfected human embryonic kidney 293-epstein-barr virus nuclear antigen cells., PMID:20071452
Presence of ecotoxicologically relevant Pgp and MRP transcripts and proteins in Cyprinid fish., PMID:20587391
Induction of intestinal multidrug resistance-associated protein 2 by glucagon-like Peptide 2 in the rat., PMID:20719938
Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats., PMID:21106720
Quantitative immunofluorescent blotting of the multidrug resistance-associated protein 2 (MRP2)., PMID:21277982
Novel roles of galectin-1 in hepatocellular carcinoma cell adhesion, polarization, and in vivo tumor growth., PMID:21391228
Rat Mrp2 gene expression is regulated by an interleukin-1β-stimulated biphasic response with enhanced transcription and subcellular shuttling of YB-1., PMID:22361279
ABCC2 is involved in the hepatocyte perinuclear barrier for small organic compounds., PMID:23041646
Effects of rhinacanthin-C on function and expression of drug efflux transporters in Caco-2 cells., PMID:23742857
A randomised phase III trial of the pharmacokinetic biomodulation of irinotecan using oral ciclosporin in advanced colorectal cancer: results of the Panitumumab, Irinotecan & Ciclosporin in COLOrectal cancer therapy trial (PICCOLO)., PMID:23953030
Expression of the ABC transport proteins MDR1 (ABCB1) and BCRP (ABCG2) in bovine rumen., PMID:24747985
WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells., PMID:24903205
Resistance and intolerance to statins., PMID:24996502
Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma., PMID:25823784
Don't trust an(t)ybody - Pitfalls during investigation of candidate proteins for methylmercury transport at the placental interface., PMID:27324094
DS-8201a, a new HER2-targeting antibody-drug conjugate incorporating a novel DNA topoisomerase I inhibitor, overcomes HER2-positive gastric cancer T-DM1 resistance., PMID:28677116
Mechanism of inhibition of taurolithocholate-induced retrieval of plasma membrane MRP2 by cyclic AMP and tauroursodeoxycholate., PMID:29192063
Immunohistochemical Assessment of the Expression of Biliary Transportation Proteins MRP2 and MRP3 in Hepatocellular Carcinoma and in Cholangiocarcinoma., PMID:29464551
Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis., PMID:30215770
Isolation of a novel glycyrrhizin metabolite as a causal candidate compound for pseudoaldosteronism., PMID:30348944
Effect of GenX on P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance-Associated Protein 2 at the Blood-Brain Barrier., PMID:32212926
The Role of Specific ATP-Binding Cassette Transporters in the Acquired Resistance to Pyrrolobenzodiazepine Dimer-Containing Antibody-Drug Conjugates., PMID:32669316
Interrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition-associated cholestasis in mice., PMID:34664730
ABCC2 expression in papillary renal cell carcinoma provides better prognostic stratification than WHO/ISUP nucleolar grade., PMID:34958810
Identification of single domain antibodies with insect cytotoxicity using phage-display antibody library screening and Plutella xylostella ATP-binding cassette transporter subfamily C member 2 (ABCC2) -based insect cell expression system., PMID:35346681
Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations., PMID:36651944
RNAi-based knockdown of candidate gut receptor genes altered the susceptibility of Spodoptera frugiperda and S. litura larvae to a chimeric toxin Cry1AcF., PMID:36710863
In vitro models to evaluate multidrug resistance in cancer cells: Biochemical and morphological techniques and pharmacological strategies., PMID:39363148
Functional expression of Bacillus thuringiensis Cry proteins on the surface of Bacillus subtilis spores., PMID:39877884
For research use only. Not for human or drug use.
