Anti-SDC4 Polyclonal Antibody

Catalog No.

PHD95501

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SDC4 (Ala18-Glu145).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

SYND4,Syndecan-4,Amphiglycan,Ryudocan core protein,SDC4

Purification

Purified by antigen affinity column.

Accession

P31431

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Trastuzumab Decreases the Expression of G1/S Regulators and Syndecan-4 Proteoglycan in Human Rhabdomyosarcoma., PMID:40076757

Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-Driven Cancers., PMID:39248702

Syndecan-4 inhibition attenuates cartilage degeneration in temporomandibular joint osteoarthritis., PMID:39101668

Targeting the oncogenic m6A demethylase FTO suppresses tumourigenesis and potentiates immune response in hepatocellular carcinoma., PMID:38839271

Integrated single-cell and spatial transcriptomics reveals heterogeneity of fibroblast and pivotal genes in psoriasis., PMID:37816883

Necroptotic TNFα-Syndecan 4-TNFα Vicious Cycle as a Therapeutic Target for Preventing Temporomandibular Joint Osteoarthritis., PMID:35278225

Infection and transmission of SARS-CoV-2 depend on heparan sulfate proteoglycans., PMID:34510494

Inhibition of syndecan-4 reduces cartilage degradation in murine models of osteoarthritis through the downregulation of HIF-2α by miR-96-5p., PMID:33850295

NRG1 fusion-driven tumors: biology, detection, and the therapeutic role of afatinib and other ErbB-targeting agents., PMID:32916265

Therapeutic Potential of Afatinib in NRG1 Fusion-Driven Solid Tumors: A Case Series., PMID:32852072

Antibody-mediated inhibition of syndecan-4 dimerisation reduces interleukin (IL)-1 receptor trafficking and signalling., PMID:32094158

Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1., PMID:28973369

Syndecans promote mycobacterial internalization by lung epithelial cells., PMID:27279134

Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation., PMID:26165408

Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKCα Activity under Mechanical Stimulation on the Elastomeric Substrates., PMID:26160374

Syndecan 4 Regulation of the Development of Autoimmune Arthritis in Mice by Modulating B Cell Migration and Germinal Center Formation., PMID:25989265

Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival., PMID:25202019

Tenascin-C-derived peptide TNIIIA2 highly enhances cell survival and platelet-derived growth factor (PDGF)-dependent cell proliferation through potentiated and sustained activation of integrin α5β1., PMID:24808173

Genome-wide siRNA screen reveals a new cellular partner of NK cell receptor KIR2DL4: heparan sulfate directly modulates KIR2DL4-mediated responses., PMID:24127555

6-o- and N-sulfated syndecan-1 promotes baculovirus binding and entry into Mammalian cells., PMID:23926339

Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity., PMID:23504321

The role of TG2 in regulating S100A4-mediated mammary tumour cell migration., PMID:23469180

Syndecan-4 phosphorylation is a control point for integrin recycling., PMID:23453597

Expression of matrix macromolecules and functional properties of EGF-responsive colon cancer cells are inhibited by panitumumab., PMID:22956286

RANTES/CCL5-induced pro-angiogenic effects depend on CCR1, CCR5 and glycosaminoglycans., PMID:22752444

Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development., PMID:22617995

Heparin/heparan sulfate/CD44-v3 enhances cell migration in term placenta-derived immortalized human trophoblast cells., PMID:22321833

RGD-independent cell adhesion via a tissue transglutaminase-fibronectin matrix promotes fibronectin fibril deposition and requires syndecan-4/2 α5β1 integrin co-signaling., PMID:20929862

Inhibitory effects of antithrombin on the expression of secretory group IIA phospholipase A(2) in endothelial cells., PMID:20846492

[Pravastatin inhibits the expression of syndecan-4 protein in tumor necrosis factor-alpha-induced rat vascular smooth muscle cells in vitro]., PMID:20501378

Interaction of syndecan and alpha6beta4 integrin cytoplasmic domains: regulation of ErbB2-mediated integrin activation., PMID:20181947

Depleting syndecan-4+ T lymphocytes using toxin-bearing dendritic cell-associated heparan sulfate proteoglycan-dependent integrin ligand: a new opportunity for treating activated T cell-driven disease., PMID:20176742

Defining the role of syndecan-4 in mechanotransduction using surface-modification approaches., PMID:20080785

Imaging of human glioma cells by means of a Syndecan-4 directed DOTA-conjugate., PMID:19777324

Glycosaminoglycans and syndecan-4 are involved in SDF-1/CXCL12-mediated invasion of human epitheloid carcinoma HeLa cells., PMID:19695308

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis., PMID:19684582

Syndecan-1 and syndecan-4 are involved in RANTES/CCL5-induced migration and invasion of human hepatoma cells., PMID:19632304

Dual role of intravitreous infliximab in experimental choroidal neovascularization: effect on the expression of sulfated glycosaminoglycans., PMID:19516009

Changes in heparan sulfate are associated with delayed wound repair, altered cell migration, adhesion and contractility in the galactosyltransferase I (beta4GalT-7) deficient form of Ehlers-Danlos syndrome., PMID:18158310

Cryptic fragment alpha4 LG4-5 derived from laminin alpha4 chain inhibits de novo adipogenesis by modulating the effect of fibroblast growth factor-2., PMID:18067585

Switch in syndecan-1 and syndecan-4 expression controls maturation associated dendritic cell motility., PMID:17576238

Stromal cell-derived factor-1/chemokine (C-X-C motif) ligand 12 stimulates human hepatoma cell growth, migration, and invasion., PMID:17259344

Expression of syndecans, cell-cell interaction regulating heparan sulfate proteoglycans, within the human endometrium and their regulation throughout the menstrual cycle., PMID:17123519

Beta1 and beta3 integrins cooperate to induce syndecan-4-containing cross-linked actin networks in human trabecular meshwork cells., PMID:16639003

The shedding of syndecan-4 and syndecan-1 from HeLa cells and human primary macrophages is accelerated by SDF-1/CXCL12 and mediated by the matrix metalloproteinase-9., PMID:16513763

Expression and function of syndecan-4 in human platelets., PMID:15968398

Syndecan-4 is required for thrombin-induced migration and proliferation in human vascular smooth muscle cells., PMID:15731100

Heparin II domain of fibronectin uses alpha4beta1 integrin to control focal adhesion and stress fiber formation, independent of syndecan-4., PMID:15572366

Fibroblast growth factor 2 endocytosis in endothelial cells proceed via syndecan-4-dependent activation of Rac1 and a Cdc42-dependent macropinocytic pathway., PMID:15226395

Syndecan-4-dependent migration of human eosinophils., PMID:15144459

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