Catalog No.
YHD08801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Phe316
Predicted molecular weight
38.02 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P15121
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Aldo-keto reductase family 1 member B1, 1.1.1.300, 1.1.1.372, 1.1.1.54, Aldehyde reductase, Aldose reductase, AR, 1.1.1.21, AKR1B1, ALDR1, ALR2
Note
For research use only.
Effects of 17β-estradiol on the uterine luteolytic cascade in bovine females at the end of diestrus., PMID:37783065
Del Nido cardioplegia or potassium induces Nrf2 and protects cardiomyocytes against oxidative stress., PMID:37842750
Repurposing of Strychnine as the Potential Inhibitors of Aldo-keto Reductase Family 1 Members B1 and B10: Computational Modeling and Pharmacokinetic Analysis., PMID:37940790
Trans-(±)-TTPG-B Attenuates Cell Cycle Progression and Inhibits Cell Proliferation on Cholangiocarcinoma Cells., PMID:37959760
Metabolic Pathways for Removing Reactive Aldehydes are Diminished in Atrophic Muscle During Heart Failure., PMID:38045249
Exploration of the Mechanism of Kaempferol in the Treatment of Cervical Cancer-based on Metabolomics and Network Pharmacology., PMID:38062663
Differential metabolites screening in yak (Bos grunniens) seminal plasma after cryopreservation and the evaluation of the effect of galactose on post-thaw sperm motility., PMID:38103402
Endogenous reductase activities for the generation of ribitol-phosphate, a CDP-ribitol precursor, in mammals., PMID:38140954
Network pharmacology combines machine learning, molecular simulation dynamics and experimental validation to explore the mechanism of acetylbinankadsurin A in the treatment of liver fibrosis., PMID:38169205
In vitro evaluation of the reductive carbonyl idarubicin metabolism to evaluate inhibitors of the formation of cardiotoxic idarubicinol via carbonyl and aldo-keto reductases., PMID:38175295
Proteomics-based screening of AKR1B1 as a therapeutic target and validation study for sepsis-associated acute kidney injury., PMID:38188141
The polyol pathway and nuclear ketohexokinase A signaling drive hyperglycemia-induced metastasis of gastric cancer., PMID:38200154
EPS15-AS1 Inhibits AKR1B1 Expression to Enhance Ferroptosis in Hepatocellular Carcinoma Cells., PMID:38230218
Effects of commonly used carbamates (carbaryl and thiram) on the regulatory, secretory and motor functions of bovine cervixes in vitro., PMID:38330862
C-C motif chemokine ligand 2 regulates prostaglandin synthesis and embryo attachment of the bovine endometrium during implantation., PMID:38438567
Decoding selectivity: computational insights into AKR1B1 and AKR1B10 inhibition., PMID:38469695
Metabolic pathways for glucose and fructose: I synthesis and metabolism of fructose by ovine conceptuses†., PMID:38501845
Network pharmacology combined with molecular docking and dynamics to assess the synergism of esculetin and phloretin against acute kidney injury-diabetes comorbidity., PMID:38578376
Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Gene Analysis., PMID:38618724
SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis., PMID:38776924
Applying Network Pharmacology and Molecular Docking in the Screening for Molecular Mechanisms of Ampalaya (Momordica charantia L.) and Banaba (Lagerstroemia speciosa L.) against Type 2 Diabetes Mellitus., PMID:38812760
Exploring the mechanism of Pueraria lobata (Willd.) Ohwi in the regulation of obesity., PMID:39154668
NRF2 inhibits RSL3 induced ferroptosis in gastric cancer through regulation of AKR1B1., PMID:39154929
The Anti-Hypoxic Mechanism of Sesamoside Determined Using Network Pharmacology., PMID:39253070
Overexpression of SLC2A1, ALDOC, and PFKFB4 in the glycolysis pathway drives strong drug resistance in 3D HeLa tumor cell spheroids., PMID:39295558
Sanger Sequencing Reveals Novel Variants in GLO-1, ACE, and CBR1 Genes in Patients of Early and Severe Diabetic Nephropathy., PMID:39336582
The challenging inhibition of Aldose Reductase for the treatment of diabetic complications: a 2019-2023 update of the patent literature., PMID:39365044
AKR1B1-dependent fructose metabolism enhances malignancy of cancer cells., PMID:39406918
Exploring fructose metabolism as a potential therapeutic approach for pancreatic cancer., PMID:39406919
Exploring the key pathogenic mechanisms and potential intervention targets for Sophorae Flavescentis radix in managing bone metastasis of lung cancer based on network pharmacology and molecular docking techniques., PMID:39524998
Association between the rs1800624 and rs80096349 SNPs and diabetic retinopathy: a pilot study., PMID:39539063
Polyol pathway-generated fructose is indispensable for growth and survival of non-small cell lung cancer., PMID:39567724
Comparative proteomic analysis of human vitreous in rhegmatogenous retinal detachment and diabetic retinopathy reveals a common pathway and potential therapeutic target., PMID:39609746
Isolation of phytoconstituents from an extract of Murraya paniculata with cytotoxicity and antioxidant activities and in silico evaluation of their potential to bind to aldose reductase (AKR1B1)., PMID:39636240
Exploration of leads from bis-indole based triazine derivatives targeting human aldose reductase in diabetic type 2: in-silico approaches., PMID:39676892
Analysis of synthetic polymer hydrogel-based generation of leukemia stem cells., PMID:39700762
Unveiling the substantial role of rutin in the management of drug-induced nephropathy using network pharmacology and molecular docking., PMID:39733639
Exploration and validation of a novel reactive oxygen species-related signature for predicting the prognosis and chemotherapy response of patients with bladder cancer., PMID:39749345
Placental Proteomics Reveals an Elevated Level of Aldo-Keto Reductase 1-B1, Highlighting Its Potential Role in Spontaneous Preterm Birth., PMID:39762117
AKR1B1 Inhibits Ferroptosis and Promotes Gastric Cancer Progression via Interacting With STAT3 to Activate SLC7A11., PMID:39911124
Identification of Known Flavonoids of Ficus carica L. as Aldose Reductase Inhibitors in Sciatic Nerve of Diabetic Neuropathy-induced Rats through Bioinformatics and Proteomics Analysis., PMID:40070327
Impact of intermittent high-dose radon exposures on lung epithelial cells: proteomic analysis and biomarker identification., PMID:40088196
The causal effects of 2,821 protein level ratios on non-small cell lung cancer: a two-sample Mendelian randomization study., PMID:40104726
A New Histology-Based Prognostic Index for Acute Myeloid Leukemia: Preliminary Results for the "AML Urayasu Classification"., PMID:40142797
Investigation of new autoantibodies in urothelial bladder cancer for biomarker discovery using immunoproteomics., PMID:40163213
In silico characterization of the interaction of AKR1B1 with the deacetylase activation domain (DAD)., PMID:40309007
The NFE2L2 (NRF2) transcription factor controls genes involved in the oxidative stress response and inflammation in myometrial cells., PMID:40360022
The Role of Claudin-1 in Enhancing Pancreatic Cancer Aggressiveness and Drug Resistance via Metabolic Pathway Modulation., PMID:40361399
AKR1B1 Expression in the Colorectal Tumor Microenvironment Contributes Towards Its Prognostic Significance., PMID:40396420
Aucubin mitigates the elevation of microglial aerobic glycolysis and inflammation in diabetic neuropathic pain via aldose reductase., PMID:40487600
For research use only. Not for human or drug use.
